The guilt experience is influenced by genetic and environmental factors, with genetics playing a significant role in determining one’s propensity for feeling guilty. Research in the field of behavioral genetics has indicated that certain personality traits associated with guilt, such as empathy, anxiety, and neuroticism, also have a genetic basis.
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BDNF
A 2015 study examined how early trauma and specific genetic variants—namely, the brain-derived neurotrophic factor (BDNF) Val66Met (rs6265), and the serotonin transporter gene promoter (5-HTTLPR)—influence guilt and other associated emotions.Â
The findings revealed that the intensity of experienced trauma correlates positively with guilt-proneness but only in adolescents who possess the low-expressing Met allele of the BDNF Val66Met polymorphism. This gene-environment interaction suggests significant implications for understanding how guilt develops and potentially contributes to psychopathology in youths.
OXTR
The OXTR gene encodes for the oxytocin receptor, a protein that binds oxytocin, a hormone significantly involved in social behavior and reproduction. Oxytocin, often referred to as the “love hormone,” plays a crucial role in various social behaviors, including mother-infant bonding, romantic attachment, and social recognition.
A 2014 study explored the genetic bases of human reconciliation behaviors, specifically self-punishment, in the context of unfair actions. Findings revealed that individuals with GA or GG genotypes of the rs53576 variant were more likely to self-punish compared to those with the AA genotype, indicating that the OXTR gene variation is linked to reconciliation tendencies, independent of feelings like guilt or shame.
ELAVL2
The ELAVL2 gene, also known as Hu-antigen B (HuB), is part of the ELAV-like family of proteins. This family includes several RNA-binding proteins in various cellular processes that regulate mRNA stability and translation. The ELAV-like proteins are key players in the post-transcriptional gene expression regulation, affecting cell proliferation, differentiation, and survival. A 2018 study found out that genetic variations in this gene (rs10119773) can influence how prone you are to feelings of guilt.
GRIA3 and GRIK1 Glutamate Receptor Genes
The GRIA3 gene encodes for Glutamate Ionotropic Receptor AMPA Type Subunit 3, a part of the AMPA receptor complex. AMPA receptors are critical components of synaptic transmission in the brain, facilitating fast synaptic transmission in the central nervous system. A 2012 study investigated the genetic underpinnings of individual depressive symptoms in 241 Korean patients diagnosed with major depression according to DSM-IV-TR criteria. Results revealed that the TT variant of rs557762 SNP of the GRIA3 gene was correlated with increased feelings of guilt among female patients.
Interestingly, the 2018 study found a SNP (rs681875) in another brain expressed glutamate receptor gene, GRIK1, to be associated with increased feelings of guilt. GRIK1 encodes for glutamate ionotropic receptor kainate type subunit 1. This association was confirmed by a 2021 study including over 450,000 participants, both female and male, which found several guilty feeling SNPs in the GRIK1 gene as well.Â