Sequencing.com Review: What You Need To Know Before Buying

Aira on August 19, 2024

About Sequencing.com

Sequencing.com offers a DNA sequencing service that allows individuals to access and understand their genetic makeup. With more affordable and accessible genetic testing available online, there is an increasing need for secure storage, meaningful interpretation, and privacy of genetic data. Sequencing.com addresses these challenges by providing free and unlimited DNA data storage, enhanced reports, and unique tools that convert complex DNA data into actionable health solutions.

The team behind these innovative services is a multidisciplinary group of U.S. medical doctors, geneticists, bioinformatics specialists, and software developers united by a common goal: to empower individuals to lead healthier, happier, and longer lives through the power of genetic insights.

Sequencing.com

How It Works

The process begins with individuals having their entire genome sequenced either through an at-home kit provided by the company or by uploading existing DNA data from other sources, such as 23andMe or Ancestry. Next, Sequencing.com offers DNA-based guidance through enhanced reports and applications. It furnishes personalized insights on aspects such as health, rare diseases, reactions to medication, nutrition, genealogy, and more.

The company also provides regular updates and ensures that clients continue to learn from and take advantage of new discoveries throughout their lives, keeping pace with the evolution of genetics.

Services

Whole Genome Sequencing

Sequencing.com provides a Whole Genome Sequencing (WGS) service delivering a comprehensive analysis of an individual’s DNA and offering a complete insight into their genetic profile. Unlike traditional DNA tests that sample less than 0.1% of a person’s DNA sequence, Sequencing.com’s WGS service sequences the entire genome, equipping individuals with detailed information to make truly informed decisions about their health.

The company uses the most advanced technology in genetic testing, covering ~30,000 genes and chromosomes end-to-end. This service, which once would have cost  $3 billion (the cost of the Human Genome Project), is now made affordable and accessible, with a  simple DNA collection process with a quick cheek swab. With the commitment to privacy, Sequencing.com offers a ‘Privacy Forever’ guarantee, ensuring the data is not sold or shared. The service includes features like the Wellness and Longevity View, Genome Explorer, and full access to raw and analyzed genome data. This service is for anyone seeking a complete picture of their health and for health professionals looking to enhance patient care.

Their WGS service comes in two packages:

  • Regular: $599
  • Premium (expedited service): $1999

Bundles

WGS + Wellness Screen for $599 includes:

  • Whole Genome Sequencing
  • One Month PLUS Genome Plan
  • Wellness and Longevity Report

Ehlers-Danlos Screen for $599 includes:

  • Whole Genome Sequencing
  • One Month PREMIUM Genome Plan
  • Next-Gen Disease Screen (Comprehensive EDS)

Rare Disease Screen for $629 includes:

  • Whole Genome Sequencing
  • One Month PREMIUM Genome Plan
  • Next-Gen Disease Screen (Comprehensive EDS)
  • Wellness & Longevity Report

Women’s Health Disease Screen for $649 includes:

  • Whole Genome Sequencing
  • One Month PREMIUM Genome Plan
  • Four reports: Next-Gen Disease Screen (Comprehensive EDS), Prevent Breast Cancer Report, Melanoma Skin Cancer Report, and Healthcare Professional Report.

Comprehensive Health Screen for $699 includes:

  • Whole Genome Sequencing
  • One Month PREMIUM Genome Plan
  • Five reports: Healthcare Professional Report, Next-Gen Disease Screen (Comprehensive EDS), Wellness & Longevity Report, Prevent Breast Cancer Report, Melanoma Skin Cancer Report

Expedited Bundles

The Expedited Sequencing Bundles utilize a unique DNA collection kit and a special laboratory for faster processing, and they include all reports listed in the Comprehensive Health Screen and more.

4 Week Turnaround – Expedited

  • Price: $1399
  • Whole Genome Sequencing with One Month PREMIUM Genome Plan
  • Includes five reports: Healthcare Professional Report, Next-Gen Disease Screen (including Comprehensive EDS), Wellness & Longevity Report, Prevent Breast Cancer Report, and Melanoma Skin Cancer Report.

2-3 Week Turnaround – Premium Expedited

  • Price: $1999
  • Whole Genome Sequencing with Three Months PREMIUM Genome Plan
  • Includes six reports: Healthcare Professional Report, Next-Gen Disease Screen + EDS, Wellness & Longevity Report, Prevent Breast Cancer Report, Melanoma Skin Cancer Report, and Medication & Drug Response Report.

Sequencing.com Marketplace

Sequencing.com marketplace offers access to around 150 apps and reports developed by certified companies and scientists worldwide. Here is a partial list of their services. For a full and updated list, check here.

Health

Inflammation DNA Wellness Report

Developed by SelfDecode

Price: $49

 

Medication & Drug Response

Developed by Complete Genome Science

Price: $59

 

Wellness and Longevity

Developed by App MD

Price: $120

 

Mood DNA Wellness Report

Developed by SelfDecode

Price: $39

 

Healthcare Pro

Developed by App MD

Price: $140

 

Vitamins DNA Wellness Report

Developed by SelfDecode

Price: $39

 

Prevent Breast Cancer

Developed by App MD

Price: $19

 

Cognitive Function Genetic Test Report

Developed by SelfDecode

Price: $59

 

Thyroid Genetic Test Report

Developed by SelfDecode

Price: $59

 

MTHFR DNA Wellness Report

Developed by SelfDecode

Price: $29

 

Empower

Developed by Toolbox Genomics

Price: $59

 

Melanoma Skin Cancer Prevention

Developed by App MD

Price: $9.99

 

Athletic Performance

Developed by App MD

Price: Free

 

Enhanced Longevity

Developed by SelfDecode

Price: $59

 

APOE4 Test | Brain Health Genetic Analysis

Developed by SelfDecode

Price: $39

Ancestry

DNA Ancestry and Genealogy‎ Report

Developed by Eone-Diagnomics Genome Center

Price: $10.99

 

Map My Genes

Developed by Genealogy Researchers

Price: $19.99

 

Map My Genes Archaeology Edition

Developed by Genealogy Researchers

Price: $19.99

 

Genetic Ancestry with Haplogroups

Developed by Complete Genome Science

Price: $59

 

Santa and Me | Compare Your DNA to St. Nick

Developed by Sequencing.com

Price: Free

 

DNA Selfie | Appearance Predictor

Developed by Sequencing.com

Price: $4.99

 

Am I An Einstein

Developed by Complete Genome Science

Price: Free

 

Genetic Genealogy Explorer

Developed by Genealogy Science

Price: Free

 

Relative Matching | DNA Family Finder

Developed by Sequencing.com

Price: Free

 

Am I Related? Relatedness Calculator

Developed by Genealogy Science

Price: $9.99

 

Ancient Ancestry DNA and Me

Developed by Genealogy Science

Price: Free

 

Y Calculator + Haplogroups

Developed by Genealogy Science

Price: Free

 

Mitochondrial MT Calculator + PhyloTree

Developed by Genealogy Science

Price: $9.99

Nutrition

Healthy Nutrition

Developed by GeneInformed

Price: $39

 

DNA Diet

Developed by GeneInformed

Price: $59

 

Nutrigenomics: Nutrition Analysis

Developed by Complete Genome Science

Price: $29

Nourish

Developed by Toolbox Genomics

Price: $59

 

Essential Minerals Report

Developed by SelfDecode

Price: $39

 

Vitamins DNA Wellness Report

Developed by SelfDecode

Price: $39

 

Nutrition

Developed by Silverberry Genomix

Price: $99

 

Weight Loss

Developed by Silverberry Genomix

Price: $139

 

Lactose Intolerance

Developed by GeneX

Price: Free

 

Free Blood Type Analysis

Developed by Complete Genome Science

Price: Free

 

Empower

Developed by Toolbox Genomics

Price: $59

 

TBG Total Wellness

Developed by Toolbox Genomics

Price: $119

 

Genetic Counseling

Developed by DNAVisit

Price: $12

The Sequencing.com Education Center

Sequencing.com offers a unique opportunity for individuals to unlock the vast potential of their DNA. Through their Education Center, they provide many content resources, expertly written and curated, to guide users through the fascinating realm of DNA, genomics, ancestry, and precision medicine.

This platform empowers people to explore how their DNA data can be utilized, enabling them to make more informed decisions for themselves and their families. As genetic research advances rapidly, Sequencing.com’s Education Center ensures that these groundbreaking developments are accessible to their users, keeping them informed and engaged with the latest in the field.

Privacy

Sequencing.com has a strong emphasis on data privacy and ownership. It assures its users that their DNA and other personal data will not be sold to third parties. As a privately held entity, a team comprising physicians and geneticists manages Sequencing.com.

The company is independent, not affiliated with or owned by large tech corporations, pharmaceutical entities, law enforcement organizations, or government agencies. This independence ensures that users’ data, including DNA information, is accessible exclusively to the individual user.

Sequencing.com meets the stringent requirements of the Health Insurance Portability and Accountability Act (HIPAA). Additionally, it adheres to the US-EU-Swiss Privacy Shield framework, reflecting its commitment to maintaining high privacy standards across different jurisdictions.

The company equates its privacy standards to those in the medical field, where patient confidentiality is paramount. They follow similarly rigorous standards, underlining a fundamental belief in safeguarding user privacy and security.

From a technical standpoint, Sequencing.com ensures robust protection of user data. They employ military-grade security measures, including AES-256 bit encryption, and store data in highly secure data centers in the United States and Europe, catering specifically to EU customers. These measures are part of their best-in-class security protocols.

Users have secure access to their DNA data and reports, which they can download. Furthermore, Sequencing.com allows users to permanently delete their data, including DNA information, anytime. The platform also facilitates securely sharing DNA data and reports with family, friends, and healthcare providers.

Do You Need To Get Your Genome Sequenced?

The relevance and utility of WGS depend on specific personal, medical, and research contexts. Here’s a breakdown to better understand when WGS is a necessity and when it’s not:

When WGS Might Be Necessary

Diagnosing Complex Genetic Conditions

In cases where patients present with complex, undiagnosed symptoms that suggest a genetic origin, WGS can be essential for identifying rare genetic disorders.

Cancer Treatment and Research

For certain types of cancer, WGS can provide crucial insights into the genetic mutations driving the cancer, which can guide targeted therapy decisions.

Pharmacogenetics

When understanding an individual’s genetic makeup can significantly influence the choice and dosage of medications, WGS can be necessary to prevent adverse drug reactions or ensure efficacy.

Rare Disease Research

In the context of research, particularly for rare diseases, WGS is often necessary to understand the genetic underpinnings of these conditions.

When WGS Is Not Necessarily Required

Routine Medical Care

For standard medical care and check-ups, WGS is not a routine necessity. Most common conditions and diseases are diagnosed and treated without needing WGS.

General Health Information

Less comprehensive or targeted genetic testing might be sufficient for individuals seeking general health information or minor genetic insights (like trait analysis).

Ancestry and Genealogy

Specific ancestry-focused genetic tests, less comprehensive and costly than WGS, are usually adequate for those interested in ancestry and family history.

Alternative To Sequencing.Com: Why LifeDNA?

LifeDNA has emerged as a prominent option for analyzing 23andMe and many other raw data sources, owing to a combination of unique offerings and a commitment to personalized wellness. 

We offer a basic DNA raw data analysis package to kickstart your journey. Users with raw data from 23andMe, AncestryDNA, etc., can access 120+ traits across interests such as Nutrition, Wellness, Vitamins and Supplements, Personality, Fitness, Sleep, Methylation, and Skincare.

Further, if you do not have raw DNA data, such as from 23andMe, LifeDNA provides that too. Start your personalized wellness journey with LifeDNA’s state-of-the-art DNA kits here.

Here is why many regard LifeDNA as the best option for making the most of your 23andMe, AncestryDNA, and other raw data:

  • Holistic Approach to Wellness: Unlike many other platforms that focus strictly on health-related risks or ancestry, LifeDNA adopts a holistic approach. We analyze genetic data to offer personalized optimizations for nutrition (including a customized grocery list!), skin care, vitamins & supplements, wellness, personality & cognition, and fitness. This range lets users get a complete picture of their wellness needs based on their DNA.
  • Product Recommendations: We go beyond just providing insights. We offer specific product recommendations, skincare ingredients, or supplements tailored to an individual’s genetic profile. It makes our service actionable, allowing users to make immediate changes based on their results.
  • Data Security: At LifeDNA, we place a high emphasis on protecting user data. Our commitment to privacy ensures that users can trust the platform with their sensitive genetic information.
  • User-Friendly Reports: LifeDNA reports are easy to interpret. Our reports are designed to be accessible to the layperson without compromising on the depth of the information.
  • Continual Updates: As genetic research evolves, so does LifeDNA’s platform. Users can expect their reports and insights to be updated with the latest scientific findings.
  • Dedicated Research and Development: At LifeDNA, we invest in research to continually refine our algorithms, ensuring that the insights provided are based on cutting-edge science.
  • Educational Resources: LifeDNA also provides ample resources for users to understand their genetic makeup better. This education-first approach demystifies the complex world of genetics, making it approachable and actionable for everyone.
  • Scientific rigor: To create an unmatched commitment to scientific rigor, LifeDNA partners with CLIA-certified, CAP-accredited, and HIPAA-compliant laboratories.

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Understanding 23andMe’s New Historical Matches Feature

Aira on August 19, 2024

23andMe has a new premium feature in their service that can reveal whether individuals are genetically related to historical figures. 23andMe’s new Historical Matches feature includes famous names such as Ludwig Van Beethoven. It also includes historically significant profiles such as a high-status Viking woman from the 9th century, an African female hunter-gatherer, or a Caquetio man from Curaçao dating back to pre-colonial times. 23andMe analyzes DNA to identify potential links between present-day individuals and their ancestors, offering insights into personal and human history. This scientific process helps individuals understand their ancestry by connecting them with past cultures and populations.

This new feature is available through its 23andMe+ Premium service. This feature allows users to identify potential genetic links to 335 historical figures by finding identical DNA segments that suggest a shared ancestor. The aim is to give users a method to trace connections to their historical lineage.

The company plans to expand the feature by adding more historical genomes. It will provide users with additional opportunities to explore their connections to history.

Dan Chu, Chief Product Officer at 23andMe, stated that “Historical Matches” represents a significant advancement in detecting genetic connections between modern individuals and historical figures. The feature uses peer-reviewed scientific methods and in-depth data analysis.

23andMe is the first prominent DNA ancestry service to offer genetic matching at this level with historical figures.

23andme's Historical Matches

How does 23andMe Match to Historical Figures?

Research by Harvard population geneticist David Reich and Svante Pääbo, a Nobel Prize winner at the Max Planck Institute for Evolutionary Anthropology, has contributed to understanding ancient human populations, migration patterns, and the relationship between Neanderthals and modern humans. Their work has challenged traditional views on human history and migration and also provided insights into disease origins that may lead to new treatments.

23andMe’s Historical Matches feature extends beyond traditional ancestry tests that trace maternal or paternal lines. This new feature scans the entire genome to find identical DNA segments that link members to historical figures who lived hundreds or even thousands of years ago.

The process uses publicly available data, scientific research, and 23andMe’s relative-matching technology to establish these connections. Like the DNA Relatives feature, Historical Matches identifies potential links by finding shared DNA segments between 23andMe+ Premium members and historical figures. The system sets quality thresholds for the length of a shared DNA segment to minimize the likelihood of incorrect matches.

Members with a 23andMe+ Premium subscription may find that they have a connection to at least one historical figure, though, per 23andMe, these connections are generally distant. In some cases, the matches may indicate closer relationships.

Which Historical Figures Are Included?

The genomes included in 23andMe’s Historical Matches feature vary widely in age; some are from individuals who lived thousands of years ago, while others date back just a few centuries. Most remain anonymous, with notable exceptions such as Ludwig van Beethoven, who passed away in 1827.

The feature provides detailed reports on each historical individual, covering aspects of their lives, how they died, and the historical context of their times, including any artifacts found with them.

Beethoven’s genetic predispositions have been explored through DNA extracted from a lock of his hair. In 2023, researchers from the University of Cambridge and the Max Planck Institute published a study analyzing Beethoven’s genome to investigate his health issues, including hearing loss, liver disease, and gastrointestinal problems.

That same year, researchers from Harvard, the Smithsonian, and 23andMe analyzed the DNA of 27 African Americans, both enslaved and freed, who worked at a Maryland iron furnace during the American Revolution and the 19th century. Published in the journal Science, the study unveils the overlooked history of these individuals. It sets the ethical and technical benchmark for studying such burial sites. Of these, the genomes of nine individuals were well-preserved, though their names are lost. The study provides insights into the harsh and often brutal conditions they endured.

Overall, the Historical Matches feature includes 335 historical figures, mostly anonymous. These individuals are grouped into different historical categories based on the original published studies, providing a narrative of their lives and times.

Which Historical Groups Are Included?

The Viking Age

During the 8th to 11th centuries, known as the Viking Age, seafaring people from Scandinavia traveled extensively, establishing settlements and trading across Europe and the North Atlantic.

Catoctin Furnace Ironworkers

The Catoctin Furnace Iron Workers consisted of enslaved and freed African American laborers who worked at one of the earliest industrial sites in the United States during the 18th and 19th centuries. This furnace produced iron goods, including artillery used during the siege of Yorktown and supplies for the Continental Army.

Iron Age Taiwan

In Taiwan, the Iron Age was when the indigenous Atayal people began utilizing metals, such as bronze, iron, and silver, for their tools and artifacts.

The Ancient Eurasian Steppe

The Eurasian Steppe is a vast expanse of grasslands extending from modern-day Hungary and Romania to Mongolia and China. It served as a significant route for human migration and played a crucial role in spreading the Indo-European languages.

The First Peoples of the Caribbean

This group includes the indigenous communities that inhabited the Caribbean region from around 1000 BC until the arrival of Spanish explorers in 1500 CE.

The Genomic Formation of South and Central Asia

Contemporary South Asian populations are primarily descendants of a mix of two ancient groups known as “Ancestral South Indians” and “Ancestral North Indians.” Ancestral South Indians emerged from an admixture of ancient Iranian farmers and southern Asian hunter-gatherers around 2000 BCE. Ancestral North Indians originated from pastoralists who inhabited the eastern Eurasian Steppe during the Bronze Age.

Late Stone Age and Iron Age South Africa

While Southern Africa is renowned for sites associated with early human ancestors dating back hundreds of thousands of years, it also has sites from more recent periods. The Late Stone Age has no definitive end date in this region. However, the Iron Age began around 200 CE with the arrival of Bantu-speaking peoples skilled in ironworking.

Ancient Northern Chinese Millet Farmers

The area between the Yellow River and the West Liao River hosted some of the world’s earliest complex agricultural societies, which cultivated millet. This cultivation and subsequent human migrations from the region helped establish millet as the staple crop of Northeast Asia nearly 8,000 years ago.

The Ancient City of Beirut

Beirut, Lebanon, has been continuously inhabited for over 5,000 years and was controlled by various empires including Assyrian, Babylonian, Persian, Greek, Roman, Byzantine, Arab, and Ottoman. Each left a cultural but not always genetic legacy.

Is the 23andMe Historical Matches Worth It?

Several users on the Reddit forum have voiced a positive opinion on this new feature. 

A user who goes by the handle ThePikminLord found the closest match with a Norse woman from Greenland, with more shared DNA than 74% of users and another with an infant girl from the Faroe Islands, with shared DNA greater than that of 71% of 23andMe users

The user Icy-You9222 reported approximately seven matches, with three from Denmark, two from Sweden, one from Estonia, and one from Ukraine. The highest percentage of shared DNA was with a young woman from Denmark, at 0.10%. As a Black American female, her Ancestry DNA results showed about 5% Swedish and Danish heritage and 1% Norwegian, while 23andMe reported 2.6% Scandinavian ancestry. She noted that these results seem consistent with her ancient Viking ancestry and expressed enjoyment in learning about her genetic background.

References

  1. https://blog.23andme.com/articles/23andmes-historic-matches
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842210/
  3. https://www.downtoearth.org.in/blog/science-technology/the-nobel-for-svante-p-bo-is-an-attempt-to-redefine-modern-man-85353
  4. https://www.cam.ac.uk/stories/beethovens-dna-reveals-health-and-family-history-clues
  5. https://hms.harvard.edu/news/historical-dna-study-connects-living-people-enslaved
  6. https://en.natmus.dk/historical-knowledge/denmark/prehistoric-period-until-1050-ad/the-viking-age/
  7. https://www.nps.gov/cato/learn/historyculture/furnace.htm
  8. https://china.usc.edu/calendar/introduction-taiwan’s-indigenous-people-and-atayal-tayan-tribe
  9. https://www.reddit.com/r/23andme/comments/1b9b9tn/my_historical_matches_i_caved_in_and_bought/
  10. https://www.reddit.com/r/23andme/comments/1b9b9tn/comment/ktvalmv/

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Promethease Review: Everything You Need To Know

Aira on August 16, 2024

What is Promethease?

Promethease, now owned by MyHeritage, is a genetics literature retrieval system that builds a personal report based on your DNA data, primarily focused on health-related genetic variants. 

The primary appeal of Promethease lies in its affordability and comprehensive reports, backed by SNPedia, a wiki database housing a vast amount of research findings related to single nucleotide polymorphisms (SNPs).

Promethease review

What is SNPedia?

SNPedia is an online database that contains information about single nucleotide polymorphisms (SNPs), which are variations at a single position in DNA among individuals. It serves as a wiki, allowing users to contribute and edit content under the oversight of its founders. SNPedia links genetic data to medical and physiological information to help individuals understand how genetic variations may influence their health and traits. 

The website utilizes data primarily from scientific studies and public databases, providing details on how specific SNPs might be associated with health conditions, traits, or responses to drugs. It’s a valuable resource for both researchers and individuals interested in personal genomics and precision medicine.

Uploading DNA Data

Getting started with Promethease is relatively straightforward. Once you access their website, they provide a list of terms and conditions you should accept before proceeding with the tool. 

Promethease review 1

You can directly import your DNA raw data file from another company or upload it manually after paying a fee of USD 12.

Promethease review 2

Promethease accepts raw data from several providers, including 23andMe, AncestryDNA, and MyHeritage DNA.

Terms in the Report Explained

Here are some terms you might encounter in a Promethease report:

  1. SNP (Single Nucleotide Polymorphism): An SNP represents a difference in a single DNA building block called a nucleotide. SNPs occur normally throughout a person’s DNA and are the most common genetic variation among people. They can act as biological markers, helping scientists locate genes associated with any disease.
  2. Genotype: Your genotype is the specific allelic composition at a particular SNP. It represents the precise variants of a gene you have inherited. For example, at given positions in the DNA, you might have a genotype of AA, AG, or GG.
  3. Magnitude: This is a measure of how significant or impactful a finding is within the report. It is a subjective score assigned by SNPedia contributors ranging from 0 (least significant) to 10 (most significant). Higher magnitudes typically indicate findings of greater potential interest or importance.
  4. Repute: This term refers to whether a SNP is considered “Good” or “Bad.” It indicates the overall effect of the SNP according to scientific studies, whether it is a protective effect or a risk factor for a condition.
  5. Frequency: This term refers to how common a particular allele of a SNP is in the general or specific populations. It helps to understand how rare or common a genetic variation is among different groups.
  6. RSID (Reference SNP cluster ID): This is an identifier used by researchers and databases to denote a specific SNP. It helps to track and reference specific genetic variations consistently across different studies and reports.
  7. Phenotype: The term phenotype refers to observable characteristics or traits of an individual that result from the interaction of their genotype with the environment. It can include physical traits like height, eye color, and disease susceptibility.
  8. Odds Ratio: This measure is used in statistical analysis to describe the strength of association or non-independence between two data values. In the context of genetics, it represents how much a particular SNP increases or decreases the risk of a disease.
  9. Risk Allele: This is the specific gene variant version associated with an increased risk of a particular trait or disease.
  10. Protective Allele: It is a version of a gene variant that can reduce the risk of a particular trait or disease.

These terms are used within Promethease reports to provide detailed insights into your genetic make-up, and how it might influence various health-related traits and conditions. Understanding these terms can help you better interpret the results of your genetic analysis.

Turn-Around-Time

It may take up to 24  hours for Promethease to generate the report, depending on the server load. 

Upon receiving the email that the report is ready, you can navigate the website and immerse yourself in a wealth of information. The report has numerous sections on various conditions, traits, and medications.

Each genetic variant in the report is presented with a magnitude score, indicating the importance of that particular SNP variant. 

Furthermore, it indicates whether the variant is good or bad and its frequency within the population.

The Promethease Report

One of the first impressions of the Promethease report is its sheer volume of data. It can feel overwhelming if you are new to genetics.

Promethease Review: Everything You Need To Know

Promethease report is text-based with limited visuals, which can be challenging to read for the uninitiated. 

The report also uses scientific language and jargon like SNP, allele, genotype, or rsID. If unfamiliar with these terms, you might frequently need to refer to external resources to understand the report fully.

Accuracy and Interpretation

Promethease pulls data from SNPedia. However, it is crucial to remember that interpreting genetic data, especially in the context of health, is complex. 

The presence of a particular SNP allele might increase the risk of a condition, but it doesn’t guarantee you’ll get it. Many factors, including other genes and environment, come into play.

Promethease emphasizes that its report is not a diagnosis and that customers should discuss concerning findings with a healthcare professional. 

Can Family Tree DNA (FTDNA) data be Uploaded to Promethease?

Family Tree DNA (FTDNA) allows users to download their raw DNA data, which they can upload to a third-party tool like Promethease for additional analysis. 

This raw data includes results from FTDNA’s Family Finder (autosomal DNA), Y-DNA, and mtDNA tests.

However, it’s important to note that Promethease is designed to interpret autosomal data related to health and traits. 

While you can technically upload Y-DNA and mtDNA data to the site, the interpretations for these data are limited, as they are not the primary focus of the Promethease database.

It is also essential to check the terms and conditions and privacy policies of any third-party tools you consider using, as using such services can often have implications for your genetic data privacy.

For the most current and detailed instructions, please visit the respective websites of Family Tree DNA and Promethease.

Promethease Privacy Policy

Promethease claims not to share, sell, or utilize your genetic data after creating the report. 

As of December 2019, after being acquired by MyHeritage, Promethease implemented a policy of deleting all DNA data files within 30 days of upload.

Is Promethease worth it?

  1. Affordability: Promethease is more affordable than similar services, making it accessible to many users.
  2. Comprehensive Data: The platform provides detailed genetic reports based on SNPs. It offers a rich source of information for individuals interested in their genetic predispositions.
  3. Data from SNPedia: Promethease uses data from SNPedia, a respected, peer-reviewed resource, which adds credibility to their reports.
  4. Privacy Focused: Promethease deletes user data within 30 days of upload, reflecting its commitment to privacy.

Accepts Data from Multiple Providers: Promethease accepts raw DNA data from many major DNA testing companies, making it a versatile choice for analysis.

Cons of using Promethease

  1. Overwhelming Information: The bulk of information provided can be overwhelming, especially for users with little to no background in genetics.
  2. Complex Terminology: Using scientific and technical language can make the reports hard to understand for laypersons.
  3. Lack of Visuals: The reports are text-based with minimal visual aids, which may detract from user experience and comprehension.
  4. Time to Generate Reports: The report can take several hours to generate, which may be inconvenient for some users.
  5. Not a Diagnostic Tool: While it provides risk estimates based on genetic variants, Promethease is not a diagnostic tool. Some users might misunderstand the nature of the information provided, leading to unnecessary worry or inappropriate health decisions.

Alternative to Promethease: Why LifeDNA?

LifeDNA has emerged as a prominent option for analyzing raw DNA data from 23andMe and many other sources, owing to a combination of unique offerings and a commitment to personalized wellness. 

We offer a basic DNA data analysis package to kickstart your journey. Users with raw data from 23andMe, AncestryDNA, etc., can access close to 200 traits across interests such as Nutrition, Wellness, Vitamins and Supplements, Personality, Fitness, Sleep, Methylation, and Skincare.

Further, if you do not have raw DNA data, such as from 23andMe, LifeDNA provides that too. Start your personalized wellness journey with LifeDNA’s state-of-the-art DNA kits here.

Here is why many regard LifeDNA as the best option for making the most of your 23andMe, AncestryDNA, and other raw DNA data:

  • Holistic Approach to Wellness: Unlike many other platforms that focus strictly on health-related risks or ancestry, LifeDNA adopts a holistic approach. We analyze genetic data to offer personalized optimizations for nutrition (including a customized grocery list!), skin care, vitamins & supplements, wellness, personality & cognition, and fitness. This range lets users get a complete picture of their wellness needs based on their DNA.
  • Product Recommendations: We go beyond just providing insights. We offer specific product recommendations, skincare ingredients, or supplements tailored to an individual’s genetic profile. It makes our service actionable, allowing users to make immediate changes based on their results.
  • Data Security: At LifeDNA, we place a high emphasis on protecting user data. Our commitment to privacy ensures that users can trust the platform with their sensitive genetic information.
  • User-Friendly Reports: LifeDNA reports are easy to interpret. Our reports are designed to be accessible to the layperson without compromising on the depth and accuracy of the information.
  • Continual Updates: As genetic research evolves, so does LifeDNA’s platform. Users can expect their reports and insights to be updated with the latest scientific findings.
  • Dedicated Research and Development: At LifeDNA, we invest in research to continually refine our algorithms, ensuring that the insights provided are based on cutting-edge science.
  • Educational Resources: LifeDNA also provides ample resources for users to understand their genetic makeup better. This education-first approach demystifies the complex world of genetics, making it approachable and actionable for everyone.
  • Scientific Rigor: To create an unmatched commitment to scientific rigor, LifeDNA partners with CLIA-certified, CAP-accredited, and HIPAA-compliant laboratories.

References

  1. https://promethease.com/
  2. https://www.snpedia.com/

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

SelfDecode Review: What You Need To Know Before You Buy

Aira on August 16, 2024

About SelfDecode

SelfDecode is a company that specializes in genetic testing and analysis. They use artificial intelligence (AI), personal genetic data, and various research databases to provide insights into your wellness. Founded in 2016, SelfDecode aims to help individuals understand their genetic makeup and how it can influence their health.

For customers who choose their most comprehensive plans, SelfDecode provides over 200 analytical reports detailing genetic health and traits. Additionally, the company offers personalized recommendations based on scientific research and individual single nucleotide polymorphisms (SNPs). For instance, if someone is at high risk for anxiety and has specific SNPs on the FAAH gene, SelfDecode might recommend cognitive-behavioral therapy as a potential intervention.

You May Also Like: 31 Frequently Asked Questions on Genetic Testing

SelfDecode also offers lab testing services through a program named SelfDecode Labs. This program allows individuals to monitor their health and receive guidance on addressing potential genetic concerns. Customers can upload existing DNA files or provide a new sample to SelfDecode. Furthermore, the company encourages customers to participate in health surveys, which aids their AI partner, Decody, in learning associations between lifestyle choices, genetic risks, and lab data to enhance personalized recommendations.

Upon receiving their genetic analysis, customers get an action plan tailored to their genetic makeup and current health status. This plan includes a Fitness and Nutrition report that outlines ideal diet and exercise routines based on genetic predispositions. Additionally, customers can opt into various programs such as health coaching, one-time genetic counseling, and personalized supplements at an extra cost.

For those who choose the more expensive Premium Insights plan, additional features become available, including access to SelfDecode’s blog SelfHacked, a comprehensive SNP database, a SNP & Gene Explorer tool, a one-on-one consultation with a health practitioner, and upcoming features such as Disease Predisposition Reports and Ancestry reports.

Selfdecode review

How It Works

Your DNA is extracted from a saliva sample or you can upload your raw data from companies like 23andMe. This genetic information is then compared to extensive, scientifically vetted databases to identify the specific SNPs in your chromosomes. These SNPs help provide tailored health recommendations.

List of DNA Raw Data Providers Accepted By SelfDecode

  • 23andMe
  • Ancestry
  • Atlas
  • Circle DNA
  • Courtagen
  • Dante Labs
  • DDC
  • Diagnomics
  • DNA.Land
  • Family Tree
  • Genes For Good
  • iGene
  • Illumina
  • Living DNA
  • Map My Genome
  • MyHeritage
  • Nebula Deep & Ultra Deep
  • Nutrition Genome
  • Sequencing
  • Strategene
  • Your Genomic Resource

SelfDecode offers three different initial price plans with two main tiers: Health Insights and Premium Insights. Each of these provides access to various levels of information and programs. The differences and similarities between these two plans are detailed below.

Pricing

Health Insights Premium Insights
Cost (DNA upload) $99 N/A
Cost (with DNA kit) $199 $319

What's Included in What?

 

Health Insights

Premium Insights

Genetic Testing and Sequencing

Yes

Yes

Access to Health Reports

Limited

Full

Personalized Health Recommendations

Yes

Yes

Personalized Supplements

Yes

Yes

SNP & Gene Explorer Tool

Yes

Yes

Lab Analyzer Tool

Yes 

Yes

Access to SelfHacked & SelfHacker Reports

No

Yes

One-on-one Consultation with a Health Practitioner

No

Yes

Personalized blogs

No

Yes

Disease Predisposition Reports

No

Yes (In development)

Ancestry Reports

No

Yes 

Price (raw data upload)

$99

–

Price (with DNA Kit)

$199

$319

Add-Ons

 

Cost

Payment Frequency

Discounts

Personalized supplements

$109+

Monthly

 

Health coaching consultations

$199

Monthly

One free with Premium Insights

Genetic counseling

$149

One-time

One free with Premium Insights

SelfDecode Labs

$39-$1,250

One-time

Subscription (12%-50%)

More About SelfDecode Labs

To assist users in monitoring their phenotypes concerning their genetic risk factors, SelfDecode offers a range of blood tests through their storefront.

SelfDecode provides a total of 355 different tests that fall into three main categories:

  • Lab Tests: These tests are conducted in a laboratory setting and focus on a single biomarker. 
  • Lab Panels: These tests assess multiple biomarkers simultaneously to provide a more comprehensive overview of the individual’s health.
  • Home Test Kits: These kits allow individuals to conduct tests in the comfort of their own homes.

For the lab tests and lab panels, individuals will need to visit a Quest Diagnostics laboratory. 

SelfDecode Reports

SelfDecode offers different types of reports like Health reports, Disease reports, Trait reports, Biohacker reports, and Personalized blogs (SelfHacked). 

Health Reports

Health Reports provide information about your health, including mental and physical aspects. This report can help you understand how your body processes micronutrients, your predisposition to health conditions, and other health-related traits. These reports, based on the analysis of specific genetic markers, are associated with particular health outcomes.

List of Health Report Categories & Traits

Brain

Anxiety, inflammation, stress, low mood, brain fog, attention, mood swings, psychological trauma, BDNF, addiction, alcohol addiction, tobacco addiction, DRD2 (dopamine), COMT (warrior versus worrier) obsessive-compulsive tendencies, and serotonin.

Heart & Blood Vessels

High blood sugar, heart health, high blood pressure, low blood pressure, high cholesterol, varicose veins, lipoprotein (a), palpitations, and artery hardening.

Hormones

An underactive thyroid, overactive thyroid, SHBG, testosterone, MDHEA, oxytocin, estradiol, and cortisol.

Gut Health

Irritable bowel syndrome, gallstones, gut inflammation, acid reflux. H. pylori infection, peptic ulcers, celiac disease, C. difficile infection, hemorrhoids, appendicitis, indigestion, gastrointestinal infection, gut microbiome diversity, constipation, and fatty liver.

Diet & Nutrition

There are too many to list individually here. But this category includes vitamins A, B1, B2, B3, B6, B7, B9, B12, C, D, E, and K; minerals (12); fats and fatty acids (11); amino acids and protein (16); food, mineral, and other allergies and sensitivities (12); MTHFR; CoQ10; carnitine; carbohydrates; and eating disorders.

Sleep

Insomnia, sleep quality, sleep apnea, deep sleep, and daytime sleepiness.

Bone, Joint, & Muscles

Joint pain, joint inflammation, bone health, gout, and carpal tunnel syndrome.

Metabolic Health

Overweight, hypoglycemia, HbA1c, lactate, metabolic rate, longevity, insulin resistance, visceral fat, and ketone bodies.

Immune Function & Inflammation

Allergies, IL-6, IL-17, neutrophils, and yeast infection.

Kidneys & Urinary Tract

Kidney health, urinary tract infections, kidney stones, overactive bladder, and eGFR.

Respiratory Health

Asthma, lung health, and sinus congestion.

Reproductive Health

Sexual dysfunction, female infertility, PCOS, painful periods, endometriosis, menstrual cycle length, irregular periods, heavy periods, and uterine fibroids.

Blood

Bilirubin, ALT, creatinine kinase, platelets, alkaline phosphatase, red blood cells, white blood cells, eosinophils, LDL cholesterol, HDL cholesterol, total cholesterol, hematocrit, ferritin, blood urea nitrogen, anemia, creatinine, total protein, albumin, uric acid, triglycerides, hemoglobin, AST, basophils, blood calcium, RDW, fasting glucose, MCHC, IGF-1, MCV, and monocytes.

Toxins

Arsenic, lead, mercury, air pollution sensitivity, mold sensitivity (airborne), and cadmium.

Skin

Psoriasis, acne, eczema, hives, rosacea, vitiligo, and heavy sweating.

Pain & Fatigue

Chronic pain, fatigue, shoulder and neck pain, migraines, headache, back pain, chronic Lyme, and restless legs.

Eyes, Ears, & Mouth

Tinnitus, gum disease, canker sores, cavities, vertigo, hearing loss, teeth grinding, and nearsightedness.

Traits ReportsTrait reports focus on observable physical or behavioral traits (phenotypes) like your reaction to caffeine, your likelihood of balding, and whether you perceive the taste of cilantro as soap-like. These reports explore the genetic basis of various traits and characteristics that may not have direct health implications but are part of what makes you unique.

Disease Reports

Disease reports provide information on genetic predispositions to specific diseases. Before accessing these reports, users must agree with the SelfDecode terms of service. Customers  should also agree to review the information in the report with the help of a doctor.

Other Tools And Reports

SelfHacked Blog

SelfDecode’s SelfHacked blog is an online resource that provides information and insights on a wide range of health and wellness topics, backed by scientific research. The blog covers a variety of subjects including genetics, health conditions, nutrition, supplements, and lifestyle interventions that can impact health and well-being.

The SelfHacked blog is designed to be a comprehensive resource that helps individuals understand the science behind different health-related topics and make informed decisions about their health. The articles are written by health and science professionals and are extensively researched to ensure accuracy and reliability.

The blog is part of the broader SelfDecode platform, which aims to empower individuals with personalized health insights based on their genetic data. Access to the SelfHacked blog is included in SelfDecode’s Premium Insights plan, providing users with an additional resource to help them understand their health and optimize their well-being.

Lab Test Analyzer Tool

The Lab Test Analyzer Tool allows users to input their lab test results and receive personalized interpretations based on their genetic data and the latest scientific research. This tool helps users understand what their lab test results mean for their health and provides actionable recommendations to improve or maintain optimal health. It can provide insights into nutrient deficiencies, hormonal imbalances, and other health-related issues that may be identified through lab tests.

SNP & Gene Explorer Tool

The SNP & Gene Explorer Tool is designed to help users explore their genetic data in-depth. SNPs are variations in a single base pair of DNA that can influence health, traits, and disease risk. The SNP & Gene Explorer Tool allows users to search for specific SNPs or genes, learn about their functions, and understand how they might impact their health. It provides detailed information on specific SNPs, including their associated health conditions, traits, and relevant scientific research. This tool is helpful for users interested in diving deep into their genetic data and learning more about how specific genetic variants may influence their health.

SelfDecode Privacy Measures

SelfDecode prioritizes customer privacy and security in its handling of genetic data. Here are some of the measures in place to protect users:

  • Sample Destruction: After analyzing the DNA, the lab destroys saliva samples to prevent unauthorized use.
  • Pseudonym Option: Users concerned about privacy can use a pseudonym or initials when submitting genetic information.
  • Data Deletion: Users can request the removal of their information from the SelfDecode database at any time.
  • Opt-Out Option: Users can opt out of surveys, lab reports, uploads, and email notifications for additional privacy.
  • Ownership of Data: Users own their genetic data and can access and download raw data and reports at any time.
  • Employee Access: Only trusted and vetted employees have access to the site’s backend, and there are dedicated teams for upholding user privacy.
  • Security Standards: SelfDecode uses modern security standards and advanced encryption methods to protect user data.
  • Consent for Research: Users must consent to participate in research conducted by SelfDecode. If users choose to participate, their information is anonymized or aggregated to remove any personal identifiers.

Overall, SelfDecode takes multiple steps to ensure the privacy and security of user data while providing users with complete control over their genetic information.

Exploring Alternatives

If your focus is more on your personal health aspects, LifeDNA might be a worthy alternative. We provide comprehensive health insights and actionable recommendations, offering a more holistic approach to DNA analysis.

Why Choose LifeDNA?

LifeDNA has emerged as a prominent option for analyzing 23andMe raw data, owing to a combination of unique offerings and a commitment to personalized wellness. Here is why many regard LifeDNA as the best option for making the most of your 23andMe raw data:

  • Holistic Approach to Wellness: Unlike many other platforms that focus strictly on health-related risks or ancestry, LifeDNA adopts a holistic approach. We analyze genetic data to offer personalized optimizations for nutrition (including a customized grocery list!), skin care, vitamins & supplements, wellness, personality & cognition, and fitness. This range lets users get a complete picture of their wellness needs based on their DNA.
  • Product Recommendations: LifeDNA goes beyond just providing insights. We offer specific product recommendations, skincare ingredients, or supplements tailored to an individual’s genetic profile. It makes our service actionable, allowing users to make immediate changes based on their results.
  • Data Security: LifeDNA places a high emphasis on protecting user data. Our commitment to privacy ensures that users can trust the platform with their sensitive genetic information.
  • User-Friendly Reports: LifeDNA reports are easy to interpret. They are designed to be accessible to the layperson without compromising on the depth and accuracy of the information.
  • Continual Updates: As genetic research evolves, so does LifeDNA’s platform. Users can expect their reports and insights to be updated with the latest scientific findings.
  • Dedicated Research and Development: LifeDNA invests in research to continually refine its algorithms, ensuring the insights provided basis of cutting-edge science.
  • Educational Resources: LifeDNA also provides ample resources for users to understand their genetic makeup better. This education-first approach demystifies the complex world of genetics, making it approachable and actionable for everyone.
  • Scientific rigor: To create an unmatched commitment to scientific rigor, LifeDNA partners with CLIA-certified, CAP-accredited, and HIPAA-compliant laboratories.

Further, if you do not have 23andMe raw data, LifeDNA provides that too. Start your personalized wellness journey with LifeDNA’s state-of-the-art DNA kits here.

LifeDNA offers a basic DNA raw data analysis package to kickstart your journey. Users with raw data from 23andMe, AncestryDNA, etc., can access 120+ traits across Nutrition and Allergy, Vitamins and Supplements, Fitness, Sleep, and Skin.

*LifeDNA is not associated with the above company.

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

GeneFood: Everything You Need To Know

Aira on August 16, 2024

About GeneFood

Gene Food, led by Dr. Aaron Gardner, emphasizes a science-first approach to personalized nutrition. The company spent its first two years reviewing genetic and nutrition studies to develop a custom nutrition plan. Their proprietary algorithm categorizes individuals into one of twenty diet types based on over 120 genetic factors. 

Since 2018, Gene Food has utilized genetic data from various providers to offer personalized nutrition advice, aiming to understand individual responses to dietary fats and other nutrition-related queries.

Gene food

Services

Individuals can order a DNA Test Kit or upload existing raw genetic data from platforms like 23andMe to receive a personalized diet plan, including a Keto Score. 

The analysis focuses on genes related to the metabolism of fats, proteins, and carbohydrates, as well as genetic markers for MTHFR, histamine, sulfur, ApoE4, and tolerances to lactose and wheat. This comprehensive evaluation forms the basis for a customized diet and nutrition strategy tailored to genetic profiles.

Pricing

Gene Food offers various services for personalized nutrition based on genetic data. 

For $95, users can upload raw DNA data from providers like Ancestry, 23andMe, or MyHeritage to receive a diet type, health reports, and food sensitivity analysis, with results in 5 minutes and options for upgrades. 

The $249 DNA Test package provides a more comprehensive analysis with additional genes for a complete score. 

For an annual fee of $99, the Health Intelligence service updates users with new genes, health reports, and access to premium content, enhancing their understanding of personal health genomics.

For 23andMe Users

The approach involves uploading the raw genetic data from platforms like 23andme or Ancestry. This data is then analyzed to assess various genetic markers related to metabolism, tolerance to certain foods, and sleep patterns. 

The report is a comprehensive nutrition plan that includes a unique diet tailored to the genetic makeup. It also offers insights into optimal fat, carbohydrate, and protein ratios, as well as personalized advice on managing LDL cholesterol, micronutrient supplementation, and dietary preferences. 

Additionally, the plan explores one’s potential for achieving nutritional ketosis, responses to saturated fat, and the viability of a plant-based keto diet, complemented by tools and tests for further personalization. It also delves into sleep chronotypes, suggesting ideal sleep schedules and productivity timings, alongside an analysis of caffeine metabolism.

List of traits:

Your Unique Diet Type

Learn the ideal ratio of fat, carbs, and protein 

LDL scoring and cholesterol absorption 

Micronutrients and Supplements 

Histamine, Dairy, Wheat, and much more  

Your Ketogenic Diet Score

Can you achieve nutritional ketosis? 

Saturated fat response 

Is plant-based keto an option? 

Keto tools and tests

Your Sleep Chronotype

Learn your ideal bedtime

Best time of day for productivity

Sleep genetics

Caffeine metabolism

Diet Types

Gene Food employs a proprietary algorithm to map individuals to one of twenty unique diet types based on an analysis of over 120 carefully selected genetic markers. This system personalizes nutrition recommendations, accommodating various dietary preferences and health objectives. These diet types are inspired by several factors, including geographical influences, modern diet research, and ancestral eating patterns, offering a tailored approach to nutrition. Gene Food’s services include DNA testing kits and the evaluation of genetic information from other providers, allowing for a comprehensive dietary planning tool.

Privacy

The company prioritizes the protection of genetic data, emphasizing privacy and security. Their genetics web applications are hosted on Amazon Web Services (AWS), known for its robust security protocols. The genetics laboratory in Houston, Texas, complies with the Clinical Laboratory Improvement Amendments (CLIA) to ensure high-quality lab testing. The company strictly adheres to privacy standards, never sharing data with third parties and using the provided data solely for delivering personalized nutrition and health insights.

Alternative to GeneFood: Why LifeDNA?

LifeDNA has emerged as a prominent option for analyzing 23andMe and many other raw DNA data sources, owing to a combination of unique offerings and a commitment to personalized wellness via our comprehensive set of multiple Reports addressing several different aspects of your overall well-being. 

We offer a basic DNA raw data analysis package to kickstart your journey. Users with raw data from 23andMe, AncestryDNA, etc., can access 194+ traits across interests such as Nutrition, Wellness, Vitamins and Supplements, Personality, Fitness, Sleep, Methylation, and Skincare.

Further, if you do not have raw DNA data, such as from 23andMe, LifeDNA provides that too. Start your personalized wellness journey with LifeDNA’s state-of-the-art DNA kits here.

Here is why many regard LifeDNA as the best option for making the most of your 23andMe, AncestryDNA, and other raw data:

  • Holistic Approach to Wellness: Unlike many other platforms that focus strictly on health-related risks or ancestry, LifeDNA adopts a holistic approach. We analyze genetic data to offer personalized optimizations for nutrition (including a customized grocery list!), skin care, vitamins & supplements, wellness, personality & cognition, and fitness. This range lets users get a complete picture of their wellness needs based on their DNA.
  • Product Recommendations: We go beyond just providing insights. We offer specific product recommendations, skincare ingredients, or supplements tailored to an individual’s genetic profile. It makes our service actionable, allowing users to make immediate changes based on their results.
  • Data Security: At LifeDNA, we highly emphasize protecting user data. Our commitment to privacy ensures that users can trust the platform with their sensitive genetic information.
  • User-Friendly Reports: LifeDNA reports are easy to interpret. Our reports are designed to be accessible to the layperson without compromising on the depth and accuracy of the information.
  • Continual Updates: As genetic research evolves, so does LifeDNA’s platform. Users can expect their reports and insights to be updated with the latest scientific findings.
  • Dedicated Research and Development: At LifeDNA, we invest in research to continually refine our algorithms, ensuring that the insights provided are based on cutting-edge science.
  • Educational Resources: LifeDNA also provides ample resources for users to understand their genetic makeup better. This education-first approach demystifies the complex world of genetics, making it approachable and actionable for everyone.
  • Scientific rigor: To create an unmatched commitment to scientific rigor, LifeDNA partners with CLIA-certified, CAP-accredited, and HIPAA-compliant laboratories.

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Dante Labs Review: Everything You Need To Know Before Buying

Aira on August 16, 2024

About Dante Labs

Dante Labs is part of Dante Genomics, a premier global genomics and precision medicine company established by Andrea Riposati and Mattia Capulli in 2016. Its mission revolves around making genomics accessible to everyone, aiming to enhance healthcare delivery, improve health outcomes, and save lives through a more human-centered approach. 

The name Dante Genomics embodies the fusion of humanity and science. Dante pays homage to the renowned Italian humanitarian poet, symbolizing the humanistic aspect. Genomics signifies the cutting-edge scientific work conducted in genomic laboratories.

Since its inception, Dante Genomics has specialized in leveraging whole genome sequencing (WGS) technology and variant interpretation. This specialization enables individuals to make informed decisions about their health and future, aligning with the company’s goal of democratizing access to genomic information. With a commitment to affordability and quality, Dante Genomics has provided hundreds of thousands of individuals with genomic solutions that inform their healthcare decisions. 

The company’s comprehensive approach extends beyond sequencing and variant interpretation, encompassing drug discovery and development, thus exemplifying its dedication to advancing the field of medicine and contributing significantly to personalized healthcare.

Dante Labs

Products

Whole Genome Sequencing

Dante Genomics specializes in WGS, a genetic testing method that decodes an individual’s entire DNA. Their service offers 30x coverage, which means the genome is analyzed 30 times, enhancing the detection of genomic information. This level of analysis provides a more detailed genetic profile compared to whole exome sequencing (WES) or targeted genetic tests.

Clients receive raw genetic data, allowing them to choose specific reports or seek further analysis from genetic counselors or clinicians. Dante Genomics caters to individuals and professionals in the medical and research fields. The Dante Genome Test, which includes sequencing the whole genome and using the company’s Extensa software platform for genomic interpretation, is available for individuals. For medical professionals and researchers, Dante Genomics provides medical genomic tests and next-generation sequencing (NGS) solutions to support research in biotechnology and academia.

The company’s Genome Manager platform enables customers to track their genome analysis process, from sample receipt to the conclusion of the analysis.

Reports

The Health and Risk Report offers individuals insights into their potential risk of developing diseases and conditions, encouraging a proactive approach to health management. It provides actionable insights based on individual genomic data, allowing for informed health decisions.

The Wellness Report informs individuals about lifestyle habits best suited to their body needs, as determined by their genomic profile. It aims to offer actionable insights for a healthier lifestyle, guiding choices in daily living.

The Scientific Fitness Report provides actionable advice on training, sports, and physical activities, all based on an individual’s whole genome. This report assists in developing a personalized workout regimen that aligns with one’s genetic makeup.

The Nutrigenetic (and Wellness Report) focuses on the relationship between food groups and an individual’s genes. It aims to help create the most effective and personalized diet plan, ideally in consultation with a specialist. This report can be instrumental in tailoring dietary choices to one’s unique genetic predispositions.

Price: USD 500. It currently costs USD 199 for the holiday season.

All panels: https://us.dantelabs.com/products/all-panels-package

Check out the full range of reports and price updates here.

Comprehensive Rare Disease Package

The Comprehensive Rare Disease Health Package offers a personalized approach to understanding and managing rare diseases. This service utilizes high-resolution whole genome sequencing combined with detailed interpretation to create a focused report on rare diseases tailored to an individual’s genetic profile. 

The package goes beyond just providing a report; it includes an opportunity for patients to discuss their results with a certified rare disease specialist via an online consultation. This approach empowers patients with knowledge and tools for proactive health management.

The package includes several key components:

  • Comprehensive Whole Genome Sequencing Test: This test thoroughly scans the entire genome with 30X coverage, offering high accuracy and reliability. It differs from other tests that only examine specific regions of the DNA, providing a more complete genetic picture.
  • Personalized Genomic Rare Disease Report: Prepared by a team of physicians and genetic counselors, this report combines a patient’s genetic profile with their medical history and symptoms. It focuses specifically on rare diseases, offering personalized insights into the patient’s DNA.
  • Rare Disease Specialist Consultation: Patients have access to a network of certified rare disease specialists. The consultation is conducted remotely, providing precise, personalized care and support.

The process for utilizing this service involves several steps:

  • Ordering the Kit: Patients receive a non-invasive collection kit shipped free of charge worldwide.
  • Sample Collection: The sample is collected using simple instructions and returned to the lab with a pre-paid shipping label.
  • Completing a Questionnaire: Patients provide personal and medical information through a secure questionnaire to personalize their results.
  • Receiving the Personalized Report: After sample processing, an in-depth report is delivered, offering insights about genetic profiles and potential rare disease risks.
  • Consulting with a Specialist: An online consultation with a rare disease specialist is scheduled to discuss report results and address any questions.

This comprehensive package is designed to help individuals with rare diseases navigate their health journey with informed and proactive care, all from the comfort of their homes.

Price: USD 799. 

Check for price updates here.

WGP HiFi Reads Whole Genome Sequencing Test

WGP HiFi Reads represent a significant advancement in whole genome sequencing technology. This method combines the advantages of short and traditional long reads in a single test, offering advanced analysis, quicker genome assembly, more uniform coverage, and a higher likelihood of sequencing difficult genome regions. 

With the use of Highly Accurate Long Reads technology, this approach delivers superior performance in various applications, including variant detection, de novo sequencing, genome structure analysis, and epigenetics studies.

The technology provides a comprehensive view of human genomes, achieving high precision and recall for all variant types, including those missed by short-read sequencing. It enables accurate detection and phasing of haplotypes across a wide range of variant types, from single nucleotide to structural variants, even in challenging genomic regions.

Overall, this integrated approach to whole genome sequencing and analysis represents the most advanced technology in the market, offering superior performance for a range of applications and personalized health and wellness insights.

Price: USD 1899 

Check for price updates here.

Privacy

Users can download their data as needed, with the flexibility to access it from any preferred location. This data access offers insights for immediate and future use. The handling of all data complies with EU GDPR and HIPAA, adhering to strict privacy standards. The organization’s policy is not to share or sell user data.

Do You Need To Get Your Genome Sequenced?

The relevance and utility of WGS depend on specific personal, medical, and research contexts. Here is a breakdown to better understand when WGS is a necessity and when it is not:

When WGS Might Be Necessary

Diagnosing Complex Genetic Conditions

In cases where patients present with complex, undiagnosed symptoms that suggest a genetic origin, WGS can be essential for identifying rare genetic disorders.

Cancer Treatment and Research

For certain types of cancer, WGS can provide crucial insights into the genetic mutations driving the cancer as a guide for targeted therapy decisions.

Pharmacogenetics

When understanding an individual’s genetic makeup can significantly influence the choice and dosage of medications, WGS can be necessary to prevent adverse drug reactions or ensure efficacy.

Rare Disease Research

In the context of research, particularly for rare diseases, WGS is often necessary to understand the genetic underpinnings of these conditions.

When WGS Is Not Necessarily Required

Routine Medical Care

For standard medical care and check-ups, WGS is not a routine necessity. Most common conditions and diseases are diagnosed and treated without needing WGS.

General Health Information

More comprehensive or targeted genetic testing might be required for individuals seeking general health information or minor genetic insights (like trait analysis).

Ancestry and Genealogy

Specific ancestry-focused genetic tests, less comprehensive and costly than WGS, are usually adequate for those interested in ancestry and family history.

Alternative To Dante Lab WGS: Why LifeDNA?

LifeDNA has emerged as a prominent option for analyzing 23andMe and many other raw data sources, owing to a combination of unique offerings and a commitment to personalized wellness. 

We offer a basic DNA raw data analysis package to kickstart your journey. Users with raw data from 23andMe, AncestryDNA, etc., can access 194+ traits across interests such as Nutrition, Wellness, Vitamins and Supplements, Personality, Fitness, Sleep, Methylation, and Skincare.

Further, if you do not have raw DNA data, such as from 23andMe, LifeDNA provides that too. Start your personalized wellness journey with LifeDNA’s state-of-the-art DNA kits here.

Here is why many regard LifeDNA as the best option for making the most of your 23andMe, AncestryDNA, and other raw data:

  • Holistic Approach to Wellness: Unlike many other platforms that focus strictly on health-related risks or ancestry, LifeDNA adopts a holistic approach. We analyze genetic data to offer personalized optimizations for nutrition (including a customized grocery list!), skin care, vitamins & supplements, wellness, personality & cognition, and fitness. This range lets users get a complete picture of their wellness needs based on their DNA.
  • Product Recommendations: We go beyond just providing insights. We offer specific product recommendations, skincare ingredients, or supplements tailored to an individual’s genetic profile. It makes our service actionable, allowing users to make immediate changes based on their results.
  • Data Security: At LifeDNA, we place a high emphasis on protecting user data. Our commitment to privacy ensures that users can trust the platform with their sensitive genetic information.
  • User-Friendly Reports: LifeDNA reports are easy to interpret. Our reports are designed to be accessible to the layperson without compromising on the depth and accuracy of the information.
  • Continual Updates: As genetic research evolves, so does LifeDNA’s platform. Users can expect their reports and insights to be updated with the latest scientific findings.
  • Dedicated Research and Development: At LifeDNA, we invest in research to continually refine our algorithms, ensuring that the insights provided are based on cutting-edge science.
  • Educational Resources: LifeDNA also provides ample resources for users to understand their genetic makeup better. This education-first approach demystifies the complex world of genetics, making it approachable and actionable for everyone.
  • Scientific rigor: To create an unmatched commitment to scientific rigor, LifeDNA partners with CLIA-certified, CAP-accredited, and HIPAA-compliant laboratories.

 

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Nebula Genomics | Whole-Genome Sequencing & DNA Testing

Aira on August 16, 2024

Disclaimer: For updated information please visit the Nebula Genomics website.

Nebula Genomics provides comprehensive genome sequencing, consistent DNA report updates, and detailed ancestry insights. Their services range from $149 to $999 based on the chosen package.

Established in 2016 by genomics scientist Professor Church, alongside his proteges Kamal Obbad and Dennis Grishin, Nebula Genomics operates out of California. Their mission is to empower individuals to securely share genomic data, thereby amassing extensive datasets crucial for propelling human genetics research forward.

October#9_Nebula

Nebula Genomics Offerings

At the heart of Nebula Genomics offerings is an in-depth genome sequencing service, with up to a 100X sequencing depth, ensuring top-notch DNA data precision. Additionally, users can access the Nebula Explore research library, a platform where you can compare your DNA against scientific findings. This can help you derive potential risk evaluations for specific health disorders.

Nebula Genomics Reports Review

Report Structure

Nebula Explore Research Library: The reports are based on individual research studies. Each report contains information about genes derived from specific study findings.

Update Frequency: New research articles are added to the Nebula library weekly, ensuring that active subscribers always have access to the latest information.

Report Content

General Overview: Each report begins with a broad overview of the subject and the studies, accompanied by an interesting fact related to the topic. This section also provides your polygenic risk score (percentile) compared to other Nebula Genomics users.

Detailed Analysis: The reports feature tables detailing the genetic findings following the general overview. These tables also indicate your genotype and whether you have an increased or decreased risk for a particular trait.

Ease of Understanding

While the charts provided are informative, the terminology used can be heavily scientific. It may be challenging for users without a background in genetics to understand without a Google search.

Additional Features

Links to Further Information: Each report links to additional resources on the topic, enhancing the depth of information available.

Mini-reports: Apart from the primary reports, Nebula offers mini-reports on various established genetic traits. These mini-reports provide a summary, an associated SNP, and a link to the original study.

Types of Traits Covered: The reports explore various categories, including:

  • Appearance & Hormones
  • Behavior & Perception
  • Body & Athleticism
  • Nutrition & Diet

Ancestry Report

Nebula Genomics has also introduced an ancestry feature. This comprehensive ancestry report draws on Y-chromosome and mitochondrial DNA for its insights. To view your report, go to the ancestry section and choose the ‘My Data’ option. It will show you a detailed breakdown of your ancestry, represented as percentages from various global regions. You can see an illustrative example of the report below:

Microbiome Report

In addition to analyzing your DNA, Nebula offers insights into the bacteria in your mouth. They utilize the same technology that decodes your DNA to understand the bacterial composition in your saliva sample.

Understanding the oral microbiome is essential. The oral microbiome is associated with conditions such as irritable bowel disease, diabetes, and Alzheimer’s disease. 

You receive a percentile that compares your oral microbiome with other users. Additionally, the report includes details from selected studies indicating potential links between your oral microbiome and specific health conditions. However, it is essential to remember that this is not intended as a diagnostic tool.

Pricing

The cost for the DNA test varies depending on sequencing depth:

  • Standard  ($99): 0.4X coverage
  • Deep ($175): 30X coverage
  • Ultra-deep ($699): 100X coverage. 

Outside the USA? Shipping costs are on you. Post-data generation, they provide a 14-day free trial of the reporting service. Post-the-trial subscription fees apply.

All packages come with a Lifetime additional membership fee, which is $200 for the Standard and $275 for the more advanced packages. 

The standard package does not capture the entirety of your DNA. The distinction between the 30X and 100X packages lies in the confidence level of the data accuracy. Further, if you are outside the USA, Nebula Genomics will not cover your shipping fees.

Upon getting your genetic data, Nebula Genomics offers a 14-day free trial for their reporting service. After this period, the service costs start at $10 monthly, or you can opt for a one-time payment of $200 or $275 for lifetime access.

Should you decide against continuing the membership subscription, you can download and use your data elsewhere. Additionally, Nebula accommodates raw DNA data uploads from different providers.

Is Whole Genome Sequencing (WGS) Worth It?

While whole genome sequencing is pricier than the conventional DNA genotyping methods adopted by companies like 23andMe and LifeDNA, these companies deploy advanced algorithms to produce variations across hundreds of thousands of genetic markers.

The pivotal decision when considering to use Nebula Genomics for a more complete DNA sequencing hinges on the value proposition of whole genome sequencing. It might not be worth it at this time.

Whole genome sequencing has not reached widespread acceptance yet among third parties. So, the downloadable raw data from Nebula may not be compatible with other platforms, as the other popular consumer genetic testing companies prefer data from other types of DNA kits.

The data volume produced by whole genome sequencing is unparalleled. However, the comparative data pool is limited. Additionally, our understanding has not evolved enough to extract insights from vast portions of our DNA. Yet, possessing this data could prove advantageous in future scenarios.

While the WGS data could become more relevant with technology advancements, its cost-effectiveness in 2023 remains debatable.

Nebula Genomics Health Guidelines

Nebula Genomics provides an extensive library for customers to compare their genetic data against, helping them discern potential predispositions to specific conditions or traits. It, however, marks the extent of their health insights.

While customers can pinpoint genetic tendencies that may put them at heightened risk for certain health conditions, Nebula falls short in offering additional insights on factors that could amplify or mitigate those risks. The platform does not provide users with tailored advice based on their findings.

This is a significant drawback. Learning that you might be susceptible to specific health challenges without guidance on potential next steps can be confusing and disconcerting.

Safety and Anonymity

Leveraging blockchain, Nebula ensures top-tier data security. They promote anonymous genetic sequencing — from payments to browsing. Though they share data with other researchers, user anonymity remains intact.

Exploring Alternatives

Are you interested in both on your DNA-based health and ancestry insights? If your focus is more on your personal health aspects, LifeDNA might be a worthy alternative. We provide comprehensive health insights and actionable recommendations, offering a more holistic approach to DNA analysis.

Why Choose LifeDNA?

LifeDNA has emerged as a prominent option for analyzing 23andMe raw data, owing to a combination of unique offerings and a commitment to personalized wellness. Here is why many regard LifeDNA as the best option for making the most of your 23andMe raw data:

  • Holistic Approach to Wellness: Unlike many other platforms that focus strictly on health-related risks or ancestry, LifeDNA adopts a holistic approach. We analyze genetic data to offer personalized optimizations for nutrition (including a customized grocery list!), skin care, vitamins & supplements, wellness, personality & cognition, and fitness. This range lets users get a complete picture of their wellness needs based on their DNA.
  • Product Recommendations: LifeDNA goes beyond just providing insights. We offer specific product recommendations, skincare ingredients, or supplements tailored to an individual’s genetic profile. It makes our service actionable, allowing users to make immediate changes based on their results.
  • Data Security: LifeDNA places a high emphasis on protecting user data. Our commitment to privacy ensures that users can trust the platform with their sensitive genetic information.
  • User-Friendly Reports: LifeDNA reports are easy to interpret. They are designed to be accessible to the layperson without compromising on the depth and accuracy of the information.
  • Continual Updates: As genetic research evolves, so does LifeDNA’s platform. Users can expect their reports and insights to be updated with the latest scientific findings.
  • Dedicated Research and Development: LifeDNA invests in research to continually refine its algorithms, ensuring the insights provided are based on cutting-edge science.
  • Educational Resources: LifeDNA also provides ample resources for users to understand their genetic makeup better. This education-first approach demystifies the complex world of genetics, making it approachable and actionable for everyone.
  • Scientific rigor: To create an unmatched commitment to scientific rigor, LifeDNA partners with CLIA-certified, CAP-accredited, and HIPAA-compliant laboratories.

Further, if you do not have 23andMe raw data, LifeDNA provides that too. Start your personalized wellness journey with LifeDNA’s state-of-the-art DNA kits here.

LifeDNA offers a basic DNA raw data analysis package to kickstart your journey. Users with raw data from 23andMe, AncestryDNA, etc. can access 120+ traits across Nutrition and Allergy, Vitamins & Supplements, Fitness, Sleep, and Skin.

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Decoding the MTHFR Gene: What It Means for Your Wellness

Aira on August 16, 2024

What Is The MTHFR Gene?

The MTHFR gene, short for Methylenetetrahydrofolate Reductase, is crucial in the body’s metabolic processes. This gene is responsible for producing the MTHFR enzyme, which plays a vital role in processing amino acids, the building blocks of all proteins. 

Specifically, MTHFR is a key in converting homocysteine, a potentially harmful amino acid, into methionine, a valuable and necessary amino acid. This process is essential for DNA methylation, which regulates gene expression and synthesizes DNA and RNA. Variations in the MTHFR gene can lead to reduced enzyme activity, affecting these critical metabolic processes. 

This gene is also significant in folate (vitamin B9) metabolism, a vital nutrient for cell division and growth. It is actually crucial for various health conditions, including cardiovascular diseases and congenital disabilities.

MTHFR Gene

Which Aspects Of Your Health Can The MTHFR Gene Influence?

The MTHFR protein plays a significant role in several aspects of health, primarily due to its involvement in processing amino acids and influencing folate metabolism. Here are some key health aspects influenced by the MTHFR:

Homocysteine Levels

MTHFR is crucial in converting homocysteine, a harmful amino acid, into methionine. Genetic variation in the MTHFR gene can lead to elevated homocysteine levels in the blood, a condition known as hyperhomocysteinemia. 

A 2010 study showed that MTHFR C677T polymorphism accounted for 1.6% of the variation in homocysteine levels. High homocysteine levels are associated with an increased risk of cardiovascular issues like heart disease and stroke.

Folate Metabolism

The MTHFR enzyme plays a vital role in converting 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a form of folate used in the methylation cycle. Variations in the MTHFR gene can affect the body’s ability to process folate (vitamin B9), leading to potential deficiencies.

Pregnancy and Fetal Development

Adequate folate levels are crucial for DNA synthesis and repair, making the MTHFR gene vital for pregnancy and fetal development. Genetic variation in this gene can increase the risk of complications such as neural tube defects in the fetus.

Response to Certain Medications

MTHFR status can influence how the body responds to certain medications, especially those affecting folate metabolism. It includes certain chemotherapy drugs.

It’s important to note that having these certain variants of the MTHFR gene doesn’t always cause health problems. The manifestation of health issues depends on various factors, including lifestyle, environmental exposures, and other genetic factors. Consulting with a healthcare provider for personalized advice and genetic counseling is advisable for those concerned about MTHFR’s possible mutations.

What is an MTHFR Gene Variation?

MTHFR gene variation refers to DNA sequence base changes in the MTHFR gene that can affect the function of the MTHFR enzyme. These variations can lead to elevated levels of homocysteine in the blood, known as hyperhomocysteinemia. This condition is associated with various health issues, including an increased risk of heart disease, stroke, and complications during pregnancy.

What are the Two Main MTHFR Gene Variations?

The two main variations (also called mutations) in the MTHFR (methylenetetrahydrofolate reductase) gene are C677T and A1298C.

MTHFR C677T (rs1801133 C>T, or G>A)

This variation is at base pair position 677 of the MTHFR gene. A change from cytosine (C) to thymine (T) can affect the enzyme’s function. People with two C677T  (C to T) variants (one from each parent) have a homozygous mutation, which can lead to lower enzyme activity compared to those with no T  or just one T-allele

  • MTHFR 677 CC (two copies of C, one from each parent)
  • MTHFR 677 CT (C from mother, T from father) 
  • MTHFR 677 TT (two copies of T, one from each parent).

This reduced activity can affect processes like folate metabolism and homocysteine levels in the body.

MTHFR A1298C (rs1801131 A>C, or T>G)

This base change occurs at position 1298 of the MTHFR gene, where cytosine (C) replaces adenine (A). Like C677T, individuals can be heterozygous (one copy of the C-allele variant) or homozygous (two copies of C) for this variant. The A1298C polymorphism can also impact the function of the MTHFR enzyme, but its effects are generally considered less severe than C677T.

These variations can impact the body’s ability to process folate and homocysteine, potentially leading to various health issues. However, the extent of their impact on health can vary among individuals, and having these variations does not necessarily mean that you will experience health problems. 

It is better to consult with a healthcare provider for personalized advice and genetic counseling if there are concerns about MTHFR mutations.

Are MTHFR Gene Variations Clinically Significant?

MTHFR C677T

A 2016 study investigated the relationship between a specific genetic variation in the MTHFR gene (C677T) and the risk of breast cancer in North Indian women (275 cases and 275 controls). The research found a significant association between the CT genotype and the T allele of the MTHFR C677T variant and an increased genetic risk for breast cancer among this population. 

A 2020 study investigated the impact of the MTHFR 677TT (two copies of the T-allele) genotype on blood pressure and hypertension risk. The study, drawing data from 6076 adults in the Joint Irish Nutrigenomics Organisation project, found that this genetic variant is associated with an increased risk of hypertension from 18 to 70 years of age. Additionally, the research revealed that low riboflavin (vitamin B2) status exacerbates this risk, particularly for those with the 677TT genotype. Those with the TT genotype also showed poorer blood pressure control when on antihypertensive treatment than those with the CT and CC genotypes. 

A 2022 meta-analysis included 81 published studies and used odds ratios to assess the association between MTHFR genetic variations and susceptibility to psychiatric disorders. The results showed a significant link between the MTHFR C677T polymorphism and increased risks of schizophrenia, major depression, and bipolar disorder, particularly in the overall population and in specific ethnic groups (notably in Asian and African populations).

A significant association between the MTHFR C677T homozygous TT genotype and an increased risk of myocardial infarction in patients with diabetes mellitus was demonstrated in this 2023 study.

MTHFR A1298C

A 2016 meta-analysis found that the MTHFR A1298C polymorphism might contribute to an elevated risk of breast and ovarian cancer, particularly breast cancer among Caucasians.

How Do We Test for MTHFR Gene Variation?

Your DNA can be analyzed for the common MTHFR variations, C677T and A1298C. The test can be ordered by a healthcare provider, especially if there’s a history of conditions like recurrent miscarriages or blood clots or if a close family member has been diagnosed with an MTHFR variation. MTHFR test is also sometimes included as part of more comprehensive genetic testing panels. 

Before undergoing the test, it’s essential to discuss with a healthcare provider the implications of the results and how they may affect overall health and treatment strategies. It’s important to understand that having an MTHFR variation doesn’t necessarily mean you will experience health problems related to that variation.

LifeDNA MTHFR Report

The LifeDNA MTHFR Report is a specialized genetic analysis focused on the MTHFR gene, which is well-known for its role in folate metabolism and many other health-related conditions. Our report provides individuals with detailed insights into their specific MTHFR gene variants and includes common polymorphisms like C677T and A1298C. 

How Do You Manage Symptoms Caused by the MTHFR Gene Variation?

Treatment for the effects of MTHFR gene variation focuses on managing homocysteine levels and ensuring adequate folate intake. This can often be achieved through dietary changes and supplementation. Foods rich in natural folate include leafy greens, legumes, nuts, and fortified grains. 

For individuals with elevated homocysteine levels or those who have difficulty metabolizing folic acid (the synthetic form of folate), healthcare providers may recommend supplements with L-methylfolate, the active form of folate. 

Improving lifestyle factors like quitting smoking and controlling blood pressure can also help mitigate any associated risks. Working with a healthcare provider to determine the best approach is important, as treatment may vary based on individual health needs and other risk factors.

References

  1. https://medlineplus.gov/genetics/gene/mthfr/
  2. https://www.ncbi.nlm.nih.gov/books/NBK6561/
  3. https://www.ncbi.nlm.nih.gov/books/NBK66131/
  4. https://academic.oup.com/hmg/article/19/10/2050/699100 
  5. https://www.webmd.com/heart-disease/homocysteine-risk 
  6. https://www.cdc.gov/ncbddd/folicacid/mthfr-gene-and-folic-acid.html 
  7. https://www.ncbi.nlm.nih.gov/books/NBK5968/
  8. https://pubmed.ncbi.nlm.nih.gov/32119295/ 
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499570/ 
  10. https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-020-01780-x
  11. https://www.frontiersin.org/articles/10.3389/fpsyt.2022.976428/full
  12. https://www.mdpi.com/2218-1989/13/2/251 
  13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416649/ 
  14. https://www.webmd.com/drugs/2/drug-162998/l-methylfolate-oral/details

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

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