Genetics Of Protein Needs: Balancing Your Macronutrients

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Genetics Of Protein Needs: Balancing Your Macronutrients

Date of Content:  November 22, 2023
Written by: Avanthika Nityanand
Reviewed by: Maarit Tiirikainen, PhD



Proteins are fundamental components of all living organisms and are crucial in virtually every biological process. As the building blocks of life, they are essential for the structure, function, and regulation of the tissues and organs. 

The significance of proteins in the body is immense and multifaceted. Understanding proteins and their functions is crucial for advancing medical science, improving health treatments, and developing nutritional guidelines tailored to individual needs.

Here is an overview of their significance:

Structural Support: Proteins provide structural support to cells and tissues. For example, collagen, a protein, is an essential component of skin, tendons, and bones.

Enzymatic Functions: Many proteins act as enzymes, speeding up biochemical reactions essential for digestion, energy production, and other metabolic processes.

Transport and Storage: Proteins transport substances across cell membranes and within the bloodstream. Hemoglobin, a protein in red blood cells, carries oxygen throughout the body.

Immune Response: Antibodies are proteins that play a critical role in the immune system, identifying and neutralizing pathogens like bacteria and viruses.

Cellular Communication: Proteins are involved in cell signaling, helping cells to communicate with each other. It is vital for processes like growth and repair.

Hormonal Regulation: Some hormones, such as insulin, are proteins. They play pivotal roles in regulating physiological processes, including metabolism, growth, and development.

Muscle Contraction: Actin and myosin, two types of proteins, are essential for muscle contraction and movement.

Proper management of protein intake is essential for various health objectives, including weight loss, muscle gain, and overall well-being. The first step in this journey is to accurately calculate your protein needs, which vary based on age, gender, activity level, and specific health goals. For the average adult, a standard guideline is consuming about 0.8 grams of protein per kilogram of body weight daily. However, if your aim is muscle gain or weight loss, this requirement often increases to around 1.2 to 2.0 grams per kilogram.

When focusing on weight loss, boosting your protein intake can be particularly beneficial. It aids in maintaining satiety, reducing overall calorie consumption, and preserving lean muscle mass even as you lose weight. Including protein powder supplements is a popular choice to increase your daily protein intake. Lean meats, eggs, dairy, legumes, nuts, and seeds are excellent food choices for protein.

For those looking to build muscle, the emphasis should not just be on the amount of protein consumed but also on its quality. Incorporating protein-rich meals and snacks throughout the day supports muscle repair and growth and complements your resistance training efforts.

Tracking your daily protein intake is another crucial aspect. Utilizing food diaries and nutrition tracking apps or maintaining a conscious awareness of the protein content in your meals can help ensure you meet your dietary targets.

The general dietary guidelines suggest that 10-35% of your daily calories should be from protein. Based on your fitness or health goals, the range is adjusted. Understanding and managing your protein consumption is critical for losing weight, gaining muscle, or staying healthy. By focusing on a balanced diet and keeping track of your intake, you can get maximum benefits from protein to meet your health objectives effectively.

Protein Intake

Genetics Of Protein Intake


The FTO gene (Fat Mass and Obesity-Associated protein) is widely studied in the context of obesity and body mass regulation. It encodes an enzyme responsible for nucleic acid demethylation (removing methyl groups from DNA, which can alter gene expression without changing the genetic sequence), playing a vital role in energy balance and metabolic processes.

Notably, variations in the FTO gene are strongly linked to an increased likelihood of obesity, as individuals with specific gene variants tend to have a higher body mass index (BMI) and are more prone to obesity. These genetic differences may influence eating behaviors, leading to an increased appetite, higher calorie intake, and a preference for calorie-dense foods.

You Might Also Like: How Do Genes Influence Weight Change? 

The enzyme produced by the FTO gene removes methyl groups from DNA, impacting the expression of other genes, especially those influencing fat storage and energy utilization. The gene’s expression in multiple body tissues, including critical areas in the brain like the hypothalamus, underscores its significant role in appetite regulation.

Variations in the FTO gene are associated with changes in dietary habits, specifically showing an association with increased energy intake, fat, and protein. A 2013 GWAS highlighted that variant (rs1421085) of the FTO gene was associated with higher protein intake.


The FGF21 gene) codes for the Fibroblast Growth Factor 21 protein, which belongs to the large fibroblast growth factor family. This protein plays a pivotal role in metabolic regulation, particularly in managing glucose uptake, insulin sensitivity, and lipid metabolism. It is essential for maintaining energy homeostasis, especially during fasting or starvation. Variant rs838133 of this gene is associated with decreased protein intake.

Non-Genetic Factors Influencing Protein Intake

Non-genetic factors influencing protein intake are diverse, encompassing various aspects of lifestyle, environment, and individual choices. These factors are crucial in determining how much protein an individual consumes. Some of the vital non-genetic factors include:

Dietary Habits and Preferences: Personal food preferences and habits greatly influence protein intake. Cultural and regional dietary patterns also play a role, as some cuisines are naturally higher in protein sources than others.

Nutritional Knowledge and Awareness: An individual’s understanding of their nutritional needs and including protein in the diet can significantly affect their protein consumption.

Understand Your Nutritional Needs. Get the LifeDNA Nutrition Report

Health and Fitness Goals: People with specific health or fitness goals, such as muscle building, weight loss, or managing a health condition, may adjust their protein intake accordingly.

Economic Factors: Economic status and affordability of food can impact protein intake. High-quality protein sources like meat, fish, and dairy can be expensive, influencing consumption patterns.

Age and Physiological Needs: Different life stages have varying protein requirements. For instance, growing children, pregnant women, and senior citizens may have increased protein needs.

Activity Level and Physical Exercise: Active individuals and athletes often have higher protein requirements to support muscle repair, growth, and overall recovery.

Health Status and Medical Conditions: Certain medical conditions, such as kidney disease, can affect how the body processes protein, influencing protein intake recommendations.

Dietary Restrictions and Allergies: Vegetarian or vegan diets and allergies to specific protein sources (like dairy or nuts) can shape how an individual meets their protein requirements.

Social and Psychological Factors: Social influences, peer groups, and psychological factors like stress and personal beliefs can impact eating behaviors and protein consumption.

Accessibility and Convenience: Easy access to protein-rich foods and the convenience of preparation can also affect protein intake. Processed and fast foods, which might be high in protein but low in nutritional quality, are often more accessible.

How To Meet Your Daily Protein Needs: For Vegetarians & Vegans

Meeting daily protein needs as a vegetarian involves incorporating various plant-based protein sources into your diet. Here is how vegetarians can ensure they get enough protein:

  1. Diversify Protein Sources: Include a variety of plant-based protein sources like lentils, chickpeas, black beans, and other legumes. These are high in protein and provide fiber and other nutrients.
  2. Include Whole Grains: Whole grains like quinoa, barley, and brown rice are good protein sources. Quinoa is particularly beneficial as it contains all nine essential amino acids.
  3. Include Soy Products: Soy products like tofu, tempeh, and edamame are excellent protein sources. You can cook them in various ways and add them to versatile recipes.
  4. Include Nuts and Seeds: Almonds, walnuts, chia seeds, flaxseeds, and hemp seeds are not only protein-rich but also provide healthy fats. You can add them to salads and yogurt or enjoy them as snacks.
  5. Eat Dairy and Eggs (for vegetarians who eat eggs): These are excellent protein sources for those who eat dairy and eggs. Greek yogurt, cheese, and eggs can significantly boost protein intake.
  6. Explore Protein-Rich Vegetables: While (most/many?) vegetables are not as high in protein as legumes and nuts, some, like broccoli, spinach, and Brussels sprouts, do contain significant amounts.
  7. Snack on Protein-Rich Foods: Choose snacks high in protein, such as yogurt, cheese, nuts, or a protein shake made with plant-based protein powder.
  8. Use Fortified Foods: Some foods and beverages contain additional protein and nutrients, such as certain plant milk and cereals.
  9. Combine Incomplete Proteins: Understand the concept of complete and incomplete proteins. Combining plant-based protein sources (like beans and rice) can ensure you get all essential amino acids.
  10. Monitor and Plan Meals: Keep track of your protein intake to ensure you meet your daily needs. Planning meals can help achieve a balanced diet that covers all essential nutrients.

Remember, the key is variety and balance. A well-planned vegetarian or vegan diet can efficiently meet the protein requirements.

About The LifeDNA Nutrition Report

Do you want to know if you have a higher genetic likelihood for lactose intolerance or gluten sensitivity, or how well your body metabolizes caffeine? The Nutrition Report from LifeDNA offers genetically tailored nutrition insights that can help optimize your wellness. The report delves into your genetic predispositions to food intolerances and provides dietary recommendations for macro and micronutrients. 

The LifeDNA Nutrition report includes a specific analysis for Protein Intake. Get yours here.


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