How Do Genes Influence Your Vitamin D Needs?

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How Do Genes Influence Your Vitamin D Needs?

Date of Content: November 14, 2023
Written by: Harvey Talento
Reviewed by: Maarit Tiirikainen, PhD


What is Vitamin D?

Vitamin D, also referred to as the “sunshine vitamin,” is a special micronutrient that our bodies need, and we also make it ourselves. It’s a kind of vitamin that dissolves in fat, and one of its main jobs is helping our bodies take in and keep important minerals such as calcium and phosphorus, which are highly important for making strong bones.

But vitamin D does more than just help our bones. Studies show that it can slow down the growth of cancer cells, help our bodies fight off infections, and reduce swelling. Our organs and tissues have special components that can grab onto vitamin D, suggesting that this vitamin has more functions than just reinforcing bones.

vitamin D

Why Does Our Body Need Vitamin D?

Vitamin D is essential for various crucial functions in the body.

Optimizing Bone Wellness

One of the primary roles of vitamin D is to support the absorption of calcium in the intestines, ensuring the body maintains proper levels of calcium and phosphorus in the blood. This balance is critical for good mineralization of bones. In children, lack of vitamin D can lead to rickets, causing the bones to soften and resulting in a bowlegged appearance. Similarly, adults with vitamin D deficiency may experience osteomalacia, characterized by weakened bones and reduced bone density, leading to muscular weakness. Prolonged vitamin D deficiency can also contribute to the development of osteoporosis.

Supporting Immunity

Vitamin D plays a crucial role in supporting immune function, and maintaining an adequate intake may help reduce the risk of autoimmune conditions. Some research suggests a potential link between long-term vitamin D deficiency and the onset of autoimmune conditions such as diabetes, asthma, and rheumatoid arthritis.

While studies in test tubes have demonstrated a positive impact of vitamin D on the immune response of human cells, further research in controlled human trials is needed to confirm these findings.

Understanding the diverse roles of vitamin D in maintaining bone wellness and supporting the immune system underscores its significance in overall well-being. Continued exploration through research will contribute to a comprehensive understanding of the far-reaching effects of vitamin D on the human body.

Genetics of Vitamin D Levels

Genetics plays a part in determining our vitamin D levels, influencing how our bodies handle and regulate this important nutrient. Scientists are exploring the impact of our genes on vitamin D to better understand its role in supporting our well-being.

GC Gene

Vitamin D’s influence on wellness is closely tied to the GC gene, which codes for the Vitamin D Binding Protein, a pivotal player in the regulation of vitamin D levels. Research indicates that variants in this gene can significantly influence the concentration of vitamin D in the bloodstream.


In the context of vitamin D dynamics, the NADSYN1/DHCR7 gene emerges as a factor of interest. Genetic analyses concerning variants such as rs12785878 provide insights into the regulatory mechanisms influencing circulating 25-hydroxyvitamin D levels.

CYP2R1 Gene

Within the complex landscape of vitamin D metabolism, the CYP2R1 plays a discernible role. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. Examining diverse groups of people reveals associations between specific gene variants, notably rs10741657, and the modulation of circulating 25-hydroxyvitamin D concentrations, contributing valuable genetic insights to the understanding of vitamin D regulation.

CYP24A1 Gene

In the intricate framework of vitamin D homeostasis, the CYP24A1 stands out as a contributor. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. 

Through systematic analysis and replication efforts, associations between certain gene variants, such as rs17216707, and the regulation of vitamin D levels become apparent, enriching our understanding of the genetic determinants of vitamin D balance.

Two other genes associated with Vitamin D levels and found on the LifeDNA’s Vitamin D Levels Report are AMDHD1 (rs10745742) and SEC23A (rs8018720), but their functional role in regulating Vitamin D levels is less known at this time. 

Unraveling the genetic factors affecting vitamin D levels provides a deeper understanding of how our bodies manage this essential nutrient. As ongoing research sheds light on the intricate interplay between genetics and vitamin D regulation, these insights can inform personalized approaches to wellness, fostering a clearer path toward optimal well-being.

Non-Genetic Factors Influencing Vitamin D Levels

Sun Exposure

The amount of sunlight available varies with geographical location, influencing the natural vitamin D synthesis by our bodies. People living at higher latitudes may experience reduced sun exposure, particularly during certain seasons or times of the day, impacting their ability to produce sufficient vitamin D.

Atmospheric Components

The atmospheric conditions, including cloud cover and pollution, can hinder the penetration of UVB rays necessary for vitamin D production. Such variations in weather patterns contribute to the risk of impaired vitamin D status, especially in regions with inconsistent sunlight.

Clothing and Sunscreen Use

Clothing coverage and the application of sunscreen act as physical barriers that limit the skin’s exposure to sunlight. While these practices are essential for sun protection, they can reduce the synthesis of vitamin D, contributing to the prevalence of low vitamin D levels.

Skin Pigmentation

Individuals with darker skin pigmentation have a natural sunscreen effect, requiring more extended sun exposure to produce the same amount of vitamin D as those with lighter skin

Age and Obesity

Age and obesity play roles in vitamin D metabolism. Aging may reduce the skin’s ability to synthesize vitamin D. At the same time, obesity can sequester vitamin D in fat tissues, affecting its bioavailability and contributing to the risk of vitamin D deficiency.

Chronic Illnesses

Several chronic illnesses, such as certain autoimmune conditions and metabolic disorders, are associated with an increased risk of vitamin D deficiency.

In summarizing these factors, it becomes evident that vitamin D levels are profoundly influenced not only by genetics but also by various non-genetic elements, emphasizing the need for a comprehensive approach to address and mitigate the widespread prevalence of low vitamin D levels across the globe.

How to Optimize Vitamin D Levels Naturally?

Understanding the sources and metabolism of vitamin D is crucial for optimizing its levels naturally. The primary source of vitamin D is cutaneous synthesis, where sunlight triggers the conversion of provitamin D to previtamin D3. However, food sources contribute only in moderate amounts, making supplementation necessary for those with limited sun exposure or reduced cutaneous synthesis, such as older adults.

Get Sun Exposure

Sunlight exposure, specifically UVB radiation, is pivotal for synthesizing vitamin D in the skin. Even a short duration of sunlight on specific body parts can produce significant amounts of vitamin D. Factors such as age, skin color, season, weather, latitude, and sunscreen use influence this synthesis. While sunlight is essential, caution is needed to avoid skin damage, while factors such as sunscreen and increased skin pigmentation can reduce vitamin D synthesis.

Eat Food Rich in Vitamin D

Food sources contribute to dietary vitamin D, with fatty fish, eggs, and fortified foods being notable examples. However, these are often not consumed in quantities sufficient for optimal vitamin D levels. For example, mushrooms, when exposed to UV light, provide a plant-based vitamin D source. While some foods are fortified, their consumption varies, making it challenging to rely solely on dietary intake for adequate vitamin D.

Consider Supplementation

Supplements become crucial, especially for individuals with limited sun exposure or reduced cutaneous synthesis, such as older adults. Fortified foods such as milk, butter, and cereals, along with vitamin D supplements, offer a reliable way to ensure consistent and adequate vitamin D intake. This is particularly important for those with malabsorption conditions, where dietary sources alone may not suffice.

Improving vitamin D levels requires a holistic approach, combining sun exposure, dietary adjustments, and supplementation. While sunlight remains a vital natural source, dietary shifts and fortification contribute to meeting vitamin D needs. Balancing nutrient intake with environmental considerations adds complexity to the equation, emphasizing the importance of personalized strategies for achieving optimal vitamin D levels.

About the LifeDNA Report

LifeDNA’s Vitamins & Supplements Report is your personalized guide to manage your Vitamin D levels, tailored to your unique genetic traits. This comprehensive report explores your genetic predispositions, providing customized dietary suggestions designed to optimize your Vitamin D levels.

Discover valuable insights into your genetic tendencies related to Vitamin D levels, paving the way for you to take the initial steps towards achieving an optimal status through the LifeDNA Vitamins & Supplements Report.

Start your journey to personalized well-being today!


  • Vitamin D, known as the “sunshine vitamin,” is crucial for calcium and phosphorus absorption, supporting the bones. Additionally, it exhibits potential benefits in immune function and cancer cell growth inhibition.
  • Vitamin D is essential for preventing bone-related conditions such as rickets and osteomalacia. It also plays a role in supporting immune function, potentially reducing the risk of autoimmune conditions.
  • Key genes, including GC, NADSYN1/DHCR7, CYP2R1, and CYP24A1, influence vitamin D regulation. Variants in these genes provide insights into the genetic determinants of vitamin D levels.
  • Sun exposure, influenced by geographical location and atmospheric conditions, along with factors such as clothing, sunscreen, skin pigmentation, age, and obesity, impacts vitamin D synthesis and metabolism.
  • Achieving optimal vitamin D levels involves balancing sun exposure, dietary sources such as fatty fish and fortified foods, and, when necessary, supplementation. Consideration of individual factors such as genetics, skin color, season, and conditions is crucial for personalized strategies.



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*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

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