Exploring the Genetic Basis of Loneliness and Its Connection to Mental Well-Being

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Exploring the Genetic Basis of Loneliness and Its Connection to Mental Health

Date of Content: January 27, 2024
Written by: Avanthika Nityanand
Reviewed by: Maarit Tiirikainen, PhD



Loneliness is a complex and often subjective emotional state characterized by a perceived lack of social connection and meaningful interpersonal relationships. It is vital to differentiate between being alone and feeling lonely; the former refers to a physical state of solitude, while the latter is a psychological experience that can occur even when surrounded by others.

At its core, loneliness is feeling disconnected, isolated, or alienated from others. Sadness, emptiness, and longing for more fulfilling social interactions accompany it. You can experience loneliness in different ways:

  • Social Loneliness: Social loneliness occurs when an individual lacks a broader social network or community. People experiencing social loneliness might have friends or family but feel disconnected from a wider social circle or community.
  • Emotional Loneliness: We feel this when there is an absence of a close emotional attachment, such as a deep friendship or intimate partner. Even if someone has many social connections, they might still experience emotional loneliness if these relationships lack emotional depth and intimacy.
  • Existential Loneliness: A more profound form, existential loneliness is feeling a fundamental sense of emptiness or isolation, questioning our place in the world or the meaning of life.

Loneliness is not inherently a mental health condition. However, chronic or severe loneliness can lead to various mental health challenges like depression, anxiety, and low self-esteem. It can also have physical health implications, such as weakened immune function and increased risk for certain chronic diseases. The experience of loneliness is highly individual, and factors such as personality, life experiences, and external circumstances can influence it.

A 2023 study conducted in the Australian population using data from the Household Income and Labour Dynamics in Australia (HILDA) reported that 34% of individuals experienced loneliness, with 21% facing it episodically and 13% chronically. In contrast, social isolation affected 17% of the population, with 13% experiencing it episodically and 4% chronically.

What’s In The LifeDNA Personality & Cognition Report?


What Can Loneliness Do to You?

Loneliness can lead to significant emotional distress and has a profound impact on mental health. It often results in feelings of sadness, emptiness, and alienation. Over time, chronic loneliness can contribute to various mental health issues like depression, anxiety, and decreased self-esteem. It also affects physical health, potentially leading to disrupted sleep patterns, increased stress levels, impaired immune function, and an elevated risk of cardiovascular diseases. Socially, it might lead to withdrawal, which can perpetuate a cycle of isolation and loneliness.

Can Loneliness Make You Sick?

Loneliness has been linked to a weakened immune system, making one more susceptible to infections. Studies have shown that loneliness can increase the levels of stress hormones in the body, leading to inflammation and a higher risk of chronic diseases like heart disease. It’s also associated with unhealthy lifestyle choices such as poor diet and lack of physical activity, which can further deteriorate health.

Can Loneliness Cause Depression?

Loneliness is a significant risk factor for depression. The lack of meaningful social connections can lead to feelings of worthlessness and hopelessness, which are central to depression. It can create a vicious cycle where loneliness leads to depression, and depression, in turn, can exacerbate feelings of loneliness. It is important to note that while loneliness can contribute to the development of depression, it is not the sole cause.

Can Loneliness Cause Anxiety?

Loneliness can contribute to the development of anxiety disorders. The feeling of being alone and unsupported can heighten stress and fear, leading to increased anxiety. It can manifest in various forms, such as social anxiety, where individuals fear social interactions, further aggravating their sense of isolation.

What Does Loneliness Do to the Brain?

On a molecular level, loneliness can alter brain chemistry and function. It can lead to increased cortisol, a stress hormone, which affects brain regions like the hippocampus and prefrontal cortex, which are involved in memory and decision-making. Chronic loneliness can also impact the production of neurotransmitters like dopamine and serotonin, which are crucial for mood regulation. It may even influence the expression of genes linked to inflammation, contributing to a heightened inflammatory response.

Can Loneliness Cause Dementia?

Research suggests a potential link between loneliness and an increased risk of dementia. Loneliness can lead to cognitive decline and may accelerate the progression of Alzheimer’s disease and other forms of dementia. This association might be due to increased stress, reduced cognitive engagement, and poorer health behaviors associated with loneliness. However, it is essential to note that while there is a correlation, loneliness is not a direct cause of dementia.

Genetics Of Loneliness

A 2017 study showed the heritability of loneliness to be between 14% and 27%, indicating a role for common genetic variations. The study also observed the highly polygenic nature of loneliness.

A 2020 twin study examined the relationship between loneliness and borderline personality disorder using genetically informative data from adult twin pairs in Australia and the Netherlands, totaling 11,329 individuals. The findings revealed that individual differences in both borderline personality and loneliness were primarily influenced by genetic factors, with heritability estimates of 41% for borderline personality total score and 36% for loneliness. Environmental influences not shared by twins also played a role. Researchers found that the genetic and environmental factors contributing to borderline personality were partially responsible for loneliness as well.


Using the UK Biobank data in a 2018 study, researchers conducted a GWAS on social interaction traits such as attendance at sports clubs, pubs, or religious groups. They found that heritability estimates for these traits were relatively low, similar to other behavioral traits, and identified 38 significant genetic loci across these traits. Some of these loci were also associated with other behavioral and psychiatric traits.

The study also revealed trait-specific genetic correlations. For example, the most strongly associated variant for pub/social club attendance was linked to the alcohol dehydrogenase gene (ADH1B), suggesting a biological basis for this behavior. Another variant associated with sports/gym attendance was the CADM2 gene, known for risk-taking propensity.

The research also found evidence of pleiotropy, where specific genetic loci influence multiple complex traits. For instance, two signals near the BARHL2 and CAMKV genes were associated with various social interaction traits and correlated with other complex traits like educational attainment and inflammatory bowel disease.

The study suggests that social interaction behaviors have a complex genetic architecture and are influenced by unique and shared genetic factors. These findings contribute to understanding the biological underpinnings of social behaviors and their association with other complex traits.

A 2023 proteome-wide analysis study explored the molecular basis of loneliness in the brain by integrating data from the human brain proteomes, transcriptomes, and loneliness GWAS. They identified 18 genes associated with loneliness via their brain protein abundance, with 11 genes replicated in a confirmatory study. They validated four of these genes at the mRNA level. The study also found that increased protein abundance of ALDH2 and ICA1L was protective against loneliness, while GPX1 increased the risk.

Non-Genetic Factors Influencing Loneliness

Non-genetic factors affecting loneliness encompass a range of environmental and personal experiences. Key factors include:

  • Social Environment: The quality and quantity of social interactions and relationships a person has.
  • Physical Environment: Living arrangements, isolation from remote locations, or confined living spaces can increase loneliness.
  • Psychological Factors: Personal traits like low self-esteem, anxiety, or depression can increase feelings of loneliness.
  • Life Events: Significant changes such as bereavement, divorce, or moving to a new location can trigger loneliness.
  • Cultural and Societal Influences: Societal norms, cultural expectations, and stigma associated with seeking social connections can influence loneliness.

These factors, individually or in combination, contribute to the experience of loneliness, underlining its multifaceted nature.

Overcoming Loneliness

Overcoming loneliness involves a compassionate and multifaceted approach:

  • Seek Social Connections: Actively pursue opportunities to connect with others, such as joining clubs, classes, or online groups.
  • Engage in Meaningful Activities: Find hobbies or activities that bring joy and a sense of purpose, often leading to new connections.
  • Volunteer: Helping others can provide a sense of belonging and reduce feelings of isolation.
  • Practice Self-Compassion and Reflection: Cultivate a positive relationship with yourself through mindfulness or therapy.
  • Stay Physically Active: Exercise can improve mood and increase opportunities for social interaction.
  • Limit Social Media: Replace passive screen time with more active, in-person interactions.
  • Seek Professional Help: If loneliness overwhelms you, consider counseling or therapy to explore underlying issues.

Helping A Loved One Battling Loneliness

Helping a loved one battling loneliness requires a caring and understanding approach:

  • Spend Quality Time: Regularly spend time with them, engaging in activities they enjoy.
  • Listen Actively: Offer a listening ear without judgment and validate their feelings.
  • Encourage Social Interaction: Encourage them to engage in social activities or join groups based on their interests.
  • Support Healthy Habits: Promote a healthy lifestyle, including physical activity, a balanced diet, and proper sleep.
  • Remain Patient and Understanding: Understand that overcoming loneliness is a process, and be patient.
  • Professional Help: Suggest professional counseling or therapy for additional support if necessary.

LifeDNA’s Personality & Cognition Report

The LifeDNA Personality Report offers intriguing insights into how your genetics might influence your behavior, emotions, and social interactions. Based on genetic markers associated with personality traits like introversion, extroversion, and emotional resilience, the report provides a detailed analysis to help you understand yourself better. Knowing your genetic predispositions can guide personal development, optimize relationships, and aid in career satisfaction.

Also Read: A Full Walkthrough Of the LifeDNA Personality & Cognition Report


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*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports and suggestions do not diagnose or treat any health conditions or provide any medical advice. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.