A Walkthrough Of The LifeDNA Fitness Report
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A Walkthrough Of The LifeDNA Fitness Report
Date of Content: January 23, 2024
Written by: Avanthika Nityanand
Reviewed by: Maarit Tiirikainen, PhD
In the realm of fitness and personal health, understanding your unique genetic makeup can be a game-changer. By delving into the details of your DNA, you can gain valuable insights into various aspects of your physical wellness and exercise preferences. This can be leveraged to tailor a fitness regimen that aligns with your body’s intrinsic characteristics.
Here are some aspects in fitness where your genetic knowledge can come in handy.
Muscle Composition
Genetics can indicate whether you have a propensity for endurance or power-based activities (more on this further in the article). For instance, some people may genetically have more fast-twitch muscle fibers, making them better suited for power and strength exercises, while others might excel in endurance sports due to a higher count of slow-twitch fibers.
Metabolism and Weight Management
Genetic testing can provide information about your body’s metabolic rate and how it processes fats and carbohydrates. This can guide you towards the most effective diet and exercise strategies for weight management.
Recovery Needs
Genetics can influence how quickly your body recovers after exercise. Understanding this can help in designing a workout schedule that allows adequate rest and recovery by preventing overtraining and injury.
Risk of Injury
Certain genetic markers can indicate a higher risk of specific injuries, like tendonitis or stress fractures. Knowing these risks can lead to implementing preventive strategies in your training routine.
Response to Types of Exercise
Your genetic makeup can influence how your body responds to different types of exercise, such as resistance training versus aerobic workouts. Tailoring your routine based on these insights can enhance effectiveness and efficiency.
Nutritional Needs
Genetics play a role in nutrient absorption and metabolism. Understanding your genetic predispositions can help tailor your diet to support your fitness goals, such as optimizing protein intake for muscle repair and growth.
Circadian Rhythm and Exercise Timing
Your genetic profile can influence your circadian rhythm, which affects the best time of day for your body to get exercised for optimal performance and results.
Section Summary
Integrating genetic insights into your fitness routine offers a more personalized approach, aligning your workouts and diet with your body’s specific needs and predispositions. This can lead to improved performance, faster achievement of fitness goals, and reduced risk of injury.
LifeDNA Fitness Report Traits
The LifeDNA Fitness Report offers a personalized analysis of how genetic factors can shape an individual’s fitness journey.
Utilizing cutting-edge genomic science, the report provides insights into nearly 30 traits spanning aspects such as muscle composition, metabolism, injury risk, and exercise response.
This information can empower you to tailor your fitness routine and nutritional plans to be in sync with your genetic makeup.
Lactate Clearance
This refers to the body’s ability to remove lactate, a byproduct of intense exercise, from your muscles. Efficient lactate clearance can reduce fatigue and improve recovery after workouts.
The rs1049434 polymorphism in the gene coding for MCT1 was shown to be linked to the occurrence of muscle injuries among elite soccer players in a 2015 study. MCT1 is one of the lactate transporters and participates in the pH homeostasis during exercise. Insufficient lactate clearance can lead to muscle injuries.
Power vs Endurance
Power is the ability to exert maximum muscular contraction instantly in an explosive burst of movements, whereas endurance is the ability to sustain these efforts over time.
Individuals’ genetic makeup plays a crucial role in determining their natural inclination towards power or endurance-based activities. The presence of the ACTN3 R577X polymorphism, especially the RR genotype (marked by rs1815739-CC), has been linked to enhanced muscle strength and power among athletes, highlighting the impact of genetics on athletic performance in power-oriented sports.
Read in more detail: Decoding the Genetics of Power vs. Endurance
Aerobic Capacity
This measures the maximum amount of oxygen your body can use during exercise. Higher aerobic capacity improves endurance and overall fitness.
Grasping the genetic basis of aerobic capacity helps explain why people respond differently to aerobic training. Research from 2014 indicates that the PPARGC1A gene, particularly its rs8192678 C>T (Gly482Ser) variant, influences the effectiveness of an individual’s response to aerobic exercise.
Read in more detail: What Does Genetics Tell About Your Aerobic Capacity
Muscle Strength
This refers to the maximum force a muscle or group of muscles can exert against some form of resistance in a single effort.
The CKM gene, responsible for producing the creatine kinase M protein, facilitates the transformation of creatine into phosphocreatine, essential for replenishing ATP (adenosine triphosphate) used up during muscle contraction. The rs8111989-C variant of the CKM gene can influence the function and production of creatine kinase M in muscles, leading to enhanced muscle strength.
Several other genetic markers can influence how well you can lift weights. Read in more detail in this article: Unlocking the Genetic Secrets of Muscle Strength
Weight Loss and Exercise
Regular exercise helps burn calories and build muscle, both of which are important for weight loss and maintaining a healthy weight.
The FTO gene is widely researched in connection with weight fluctuation. Various genetic variants in this gene are associated with a higher likelihood of obesity and challenges in sustaining a healthy weight. Those with particular variants inthe FTO gene may experience more difficulty in managing their hunger and regulating how much they eat.
We address the mechanics of the FTO gene in this article: How Your Genes Influence Weight Change
Also read: The Genetics Of Saturated Fat Metabolism
Blood Pressure & Exercise
Regular physical activity can help lower high blood pressure and reduce the risk of hypertension.
Research indicates that a specific genetic variant (rs5370) in the EDN1 (endothelin 1) gene is associated with an increased risk of high blood pressure, particularly in individuals with lower fitness levels.
Read about more genetic markers related to blood pressure in this article: From Genes to Cardiovascular Health: Understanding Blood Pressure and Exercise
HDL Cholesterol & Exercise
Exercise can boost levels of HDL cholesterol, the ‘good’ cholesterol, which helps reduce heart disease risk.
Gene polymorphisms in peroxisome proliferator-activated receptors (PPARs) and their coactivators, particularly PPARGC1A and PPARGC1B, have a notable connection with how people respond to aerobic training. Research has shown that individuals with certain variants of these genes may experience unique responses to aerobic exercises.
Read in more detail: The Science Behind High-Density Lipoprotein: Genetics and Exercise Insights
Insulin Sensitivity & Exercise
Regular exercise can improve insulin sensitivity, which can be beneficial for managing blood sugar levels, especially in people with type 2 diabetes.
Explore our in-depth analysis of the link between genetics and insulin sensitivity in this article Genetic Insights into Insulin Sensitivity and Exercise
Motivation to Exercise
This involves the desire or willingness to engage in physical activity. Motivation can be influenced by various psychological and environmental factors as well as genetics.
A 2012 study on the NOS3 +894 G>T polymorphism (rs1799983) found that it affects physical activity levels and muscle strength response to resistance training.
Exercise Heart Rate Recovery
This is a measure of how well your heart rate recovers after exercise, which can indicate cardiovascular fitness and endurance.
Injury Predisposition
This refers to one’s susceptibility to injury from a workout, which can be influenced by factors like genetics, muscle strength, and flexibility.
A 2017 meta-analysis of six studies involving 933 cases and 1,381 controls v revealed that the rs1800012 SNP in a collagen gene COL1A1 is significantly associated with a decreased risk of sports-related tendon and ligament injuries, particularly ACL injuries, with the TT genotype potentially serving a protective role.
Hand Grip Strength
This is a measure of the strength in your hands and forearms. It’s a good indicator of overall muscle strength.
In 2017, a comprehensive GWAS involving 195,180 individuals identified 16 genetic loci linked to hand grip strength were identified, implicating genes related to muscle structure, neuronal functions, and psychomotor impairment. The study offered new insights into the biological mechanisms of muscular strength and its impact on age-related health issues.
Bone Density & Fracture Risk
Bone density refers to the strength of bones, with higher density indicating stronger bones and lower risk of fractures.
A large genome-wide association study (GWAS) using UK Biobank data identified 1,362 independent SNPs linked to bone mineral density, leading to the development of a genetic algorithm that, when combined with physical factors like height, weight, age, and sex, significantly predicts the risk of osteoporosis and fractures.
Testosterone
A key male hormone, also present in females, that affects muscle mass, bone density, and red blood cell production.
Testosterone levels in the body are influenced by a complex interplay of multiple genes and genetic markers, rather than a single gene dedicated to regulating testosterone. Various genetic factors can impact the production, regulation, and sensitivity of testosterone. Notably, several genetic variations in the SHBG (sex hormone-binding globulin) gene locus on chromosome 17 are associated with significant fluctuations in testosterone levels and a heightened risk of low testosterone. The rs6258 polymorphism in the SHBG gene, for instance, influences how testosterone binds to SHBG, affecting the availability of free testosterone in the body.
Read in more detail: Testosterone Genetics: Insights into Male Hormonal Traits
Post-Exercise Recovery Rate
This indicates how quickly your whole body recovers after exercise, including muscle and tissue repair and return to resting heart rate.
The TNFA G-308A (rs1800629-A) genetic variant significantly influences how the body recovers after intense exercise. This variation affects the systemic response of creatine kinase (CK), a crucial indicator of muscle damage, during strenuous physical activity. People with the TNFA G-308A genotype may show different CK activity following intense exercise.
Explore this in more detail in our article, A Comprehensive Genetic Guide to Post-Exercise Recovery Rate
Exercise-Induced Ischemia
This refers to reduced blood flow to the heart during exercise, which can cause chest pain or discomfort.
A large 2014 systematic review of nearly 30 case-control studies (including 8,901 cases and 12,623 controls) revealed a significant association between the MCP-1 A-2518G polymorphism and increased risk for both IHD and IS across various genetic models (dominant, allelic, recessive, and additive).
We discuss several other genes and SNPs in our article, Exploring Genetic Factors in Exercise-Induced Ischemia
Circadian Rhythm
This is your body’s internal clock that influences physical, mental, and behavioral changes in a roughly 24-hour cycle, affecting sleep, hormone release, and even exercise performance.
Studies have identified specific genes, such as CLOCK, PER1, PER2, and PER3, closely associated with regulating circadian rhythms. Read our full article on The Genetics of Circadian Rhythm.
Unlock all LifeDNA Fitness Traits now.
Why LifeDNA?
LifeDNA has emerged as a prominent option for analyzing 23andMe and many other raw DNA data, owing to a combination of unique offerings and a commitment to personalized wellness.
We offer a basic DNA raw data analysis package to kickstart your journey. Users with raw data from 23andMe, AncestryDNA, etc., can access 194+ traits across interests such as Nutrition, Wellness, Vitamins and Supplements, Personality, Fitness, Sleep, Methylation, and Skincare.
Further, if you do not have raw DNA data, such as from 23andMe, LifeDNA provides that too. Start your personalized wellness journey with LifeDNA’s state-of-the-art DNA kits here.
Here is why many regard LifeDNA as the best option for making the most of your 23andMe, AncestryDNA, and other raw data:
- Holistic Approach to Wellness: Unlike many other platforms that focus strictly on health-related risks or ancestry, LifeDNA adopts a holistic approach. We analyze genetic data to offer personalized optimizations for nutrition (including a customized grocery list!), skin care, vitamins & supplements, wellness, personality & cognition, and fitness. This range lets users get a complete picture of their wellness needs based on their DNA.
- Product Recommendations: We go beyond just providing insights. We offer specific product recommendations, skincare ingredients, or supplements tailored to an individual’s genetic profile. It makes our service actionable, allowing users to make immediate changes based on their results.
- Data Security: At LifeDNA, we emphasise on protecting user data. Our commitment to privacy ensures that users can trust the platform with their sensitive genetic information.
- User-Friendly Reports: LifeDNA reports are easy to interpret. We have designed our reports to be accessible to the layperson without compromising on the depth and accuracy of the information.
- Continual Updates: As genetic research evolves, so does LifeDNA’s platform. Users can expect their reports and insights to be up-to-date with the latest scientific findings.
- Dedicated Research and Development: At LifeDNA, we invest in research to continually refine our algorithms, ensuring that we base the insights on cutting-edge science.
- Educational Resources: LifeDNA also provides ample resources for users to understand their genetic makeup better. This education-first approach demystifies the complex world of genetics, making it approachable and actionable for everyone.
- Scientific rigor: To create an unmatched commitment to scientific rigor, LifeDNA partners with CLIA-certified, CAP-accredited, and HIPAA-compliant laboratories.
Customer Reviews
*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.
Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.
