Decoding Your Cravings: How Genes Shape Fatty Food Preferences

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Decoding Your Cravings: How Genes Shape Fatty Food Preferences

Date of Content: October 6, 2023
Written by: Jess Gayo
Reviewed by: Maarit Tiirikainen, PhD

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Overview

What Are Fatty Foods?

If you’ve ever craved a greasy pizza after a fun night out or wanted a good bite of the juicy ham at dinner, you are most likely familiar with how delicious fatty foods can be. Often deemed unhealthy, fats in general are essential to the human diet. It simply boils down to the type of fats you consume and their source. 

A group of nutritional items known as “fatty foods” are distinguished by their high-fat content. Dietary fats are a crucial macronutrient that the body needs for several important processes. They are a concentrated source of energy, aid in the absorption of fat-soluble vitamins, and support many physiological functions. Foods’ flavor, texture, and satiety are all enhanced by fats.

Preference To Fatty Foods

Types of Fats and Their Palatability

Fatty foods can be broadly categorized into different types of fats, with the two primary categories being:

  1. Saturated Fats: These fats are frequently present in animal-based goods including meat, butter, and full-fat dairy, and are usually solid at room temperature. Saturated fats are also present in significant levels in some plant oils, such as coconut and palm oil.
    • Food Sources: Saturated fats are commonly found in animal-based products like red meat, poultry, full-fat dairy products, and some plant oils like coconut oil and palm oil.
    • Palatability: Saturated fats are known for their rich, creamy, and indulgent taste. They contribute to the mouthfeel, texture, and overall flavor of many foods, making them palatable. This palatability, however, can lead to overconsumption if not eaten in moderation.
  2. Unsaturated Fats: These fats are frequently seen as healthier and are typically liquid at room temperature. They can be further broken down into polyunsaturated fats (found in fatty fish, flaxseeds, and sunflower oil) and monounsaturated fats (found in olive oil, avocados, and nuts). Heart health is one of the many advantages of unsaturated fats in terms of health.
    • Food Sources: Unsaturated fats are found in various plant-based oils (e.g., olive oil, canola oil), fatty fish (e.g., salmon, mackerel), nuts, seeds, and avocados.
    • Palatability: Unsaturated fats can contribute to a mild, sometimes nutty, or fruity flavor in foods. While they may not offer the same level of richness and palatability as saturated fats, their subtler taste is often appreciated, especially in dishes where the flavor of the food itself is more prominent.

Saturated fats are frequently preferred when it comes to palatability because of their capacity to improve the flavor and texture of numerous foods. However, consuming too much saturated fats has been linked to adverse health effects, especially on the heart. 

On the other hand, unsaturated fats are recommended in a balanced diet because of their favorable effects on heart health and general well-being. They are therefore seen as healthier alternatives. For taste and nutrition, it’s crucial to balance both types of fat in your diet, with an emphasis on decreasing saturated fat intake for optimum health.

Why Do People Crave Fatty Foods?

Interestingly, people often crave fatty foods for several reasons, both physiological and psychological. According to human evolution studies, calorie-dense foods, including fatty items, were essential for survival during times of scarcity. Early humans who craved and consumed high-energy foods were more likely to endure and reproduce, passing down their genes.

 

Fats also provide a concentrated source of energy, offering more than twice the calories per gram compared to carbohydrates and proteins. Cravings for fatty foods may signal the body’s need for an energy boost. Moreover, fatty foods are often rich, creamy, and flavorful, making them rewarding. The mouthfeel and taste of fats can trigger pleasure centers in the brain, leading to cravings.

While cravings for fatty foods are natural, try to strike a balance in your daily diet to ensure overall health. Moderation and mindful eating are key to enjoying fatty foods while maintaining a nutritious and well-rounded diet.

The Science Behind Fatty Food Preferences

Many factors, such as biology, culture, personal psychology, and environmental cues, have an impact on people’s preferences for fatty foods. People can preserve preferences that support general well-being by being aware of these influencing factors and making thoughtful food decisions.

Genetics Influencing Preference for Fatty Food

There is no single genetic marker that exclusively determines one’s preference for fatty foods. Instead, multiple genes and genetic variations collectively contribute to this complex trait. 

CD36 Gene

Individuals’ perceptions of the flavor of lipids can be influenced by genetic variances in taste receptor genes. Differential perceptions of fat have been associated with the CD36 gene in particular. An individual’s sensitivity to the taste of fats and desire for fatty foods can be affected by variations in this gene.

TAS2R38 Gene

This gene encodes a taste receptor related to bitter taste perception. Genetic variations in TAS2R38 can influence how individuals perceive the taste of fatty foods and may affect their preferences.

DRD2 Gene

The DRD2 gene is associated with dopamine receptor D2, which plays a role in the brain’s reward pathways. Variations in this gene can influence how the brain responds to the consumption of rewarding foods, such as fast food, potentially also affecting fatty food preferences.

MC4R Gene

The MC4R gene is associated with appetite regulation. Genetic variations in MC4R may affect hunger and satiety signals and, subsequently, an individual’s food preferences.

LEPR Gene

The LEPR gene encodes the leptin receptor, which plays a role in appetite regulation. Genetic variations in LEPR may affect an individual’s susceptibility to food cravings, including those for fatty foods.

AGRP Gene

The Agouti-related protein (AGRP) affects appetite and can make you overeat if it’s added to your brain or if you have too much of it in your body. When scientists looked at two specific gene variations related to AGRP in different ethnic groups, they found interesting connections to how people eat. One study shows that these gene variations, previously connected to being lean, are also connected to the types of food people eat in different ethnic groups.

Other Genetic Markers

Other genetic markers in LifeDNA’s Preference for Fatty Foods Report include SNPs rs9939609 (FTO), rs1801282 (PPARG), rs2270188 (CAV2), and rs1800206 (PPARA).

The connections between genetics and dietary preferences are complicated, and these genetic markers only represent a small percentage of the genetic and physiological components involved in food preferences. In addition, lifestyle choices made by an individual, societal norms, and the environment all influence what they eat. More information regarding the genetic basis of food preferences, especially those for fatty meals, is likely to become available as this field of study develops.

Environmental Factors Influencing Preference for Fatty Food

Preference for fatty foods can be influenced by a variety of environmental factors. These external influences, in addition to genetic and physiological factors, play a significant role in shaping individual dietary choices. Here are some key environmental factors that can impact one’s preference for fatty foods:

Food Environment

  • Food Availability: The availability and accessibility of fatty foods in the local food environment can strongly influence preferences. The prevalence of fast-food restaurants, convenience stores, and processed foods in a person’s surroundings can promote the consumption of fatty foods.
  • Food Sensory Appeal: The sensory appeal of fatty foods, including their taste and texture, can be enhanced through food preparation techniques such as frying and baking. The sensory experience of these foods in restaurants and at home can contribute to preferences.
  • Food Packaging and Presentation: The way fatty foods are packaged and presented in stores can affect preferences. Attractive packaging, appealing visuals, and food placement in stores can draw consumers toward high-fat options.
  • Lack of Nutritional Education: Limited knowledge about the nutritional content and health implications of fatty foods can lead to less informed dietary choices, which may favor high-fat options.
  • Marketing and Advertising: The marketing and advertising of fatty foods can create powerful incentives for consumption. Eye-catching advertisements and promotional strategies can make fatty foods more appealing and contribute to preferences.

Socio-Environmental Influences

  • Family and Peer Influence: The dietary habits of family members and peer groups can shape individual food preferences. If family or friends often consume fatty foods, individuals are more likely to do the same.
  • Cultural Influences: Cultural traditions and societal norms related to food can have a profound impact on food preferences. In some cultures, high-fat foods are a fundamental part of traditional dishes and celebrations, influencing preferences for these foods.
  • Social Settings and Celebrations: Social gatherings and celebrations often feature foods high in fat, which can lead to an increased preference for these foods in a social context.

Personal Factors

  • Emotional and Stress Eating: Emotional states and stress can lead to cravings for comfort foods, often high in fat. Emotional eating can be influenced by environmental stressors and emotional cues.
  • Economic Factors: Economic factors, including the cost of food, can influence preferences. In some cases, high-calorie, energy-dense foods like fast food may be more affordable and accessible than healthier alternatives.
  • Convenience and Time Constraints: Busy lifestyles and time constraints may lead individuals to opt for convenient, high-fat options when preparing healthier meals seems impractical.

These environmental factors can work in concert with genetic and physiological factors to shape food preferences. Recognizing and understanding these external influences is essential for making informed dietary choices and promoting healthier eating habits.

How Does Fatty Food Impact Health?

Fatty foods can have both positive and negative impacts on health, depending on the type and quantity of fats consumed. 

Potential Positive Benefits

  1. Source of Energy: Fats are a concentrated source of energy, providing 9 calories per gram. They serve as a vital energy reserve, especially during prolonged physical activity or when carbohydrates are limited.
  2. Essential Nutrients: Dietary fats are essential for the absorption of fat-soluble vitamins (A, D, E, and K), which play crucial roles in various bodily functions.
  3. Brain Health: The brain is composed of a significant amount of fat, and dietary fats are essential for brain development and function. Omega-3 fatty acids, in particular, are associated with cognitive health.

Potential Negative Impacts

  1. Weight Gain and Obesity: Excessive consumption of high-fat, calorie-dense foods can contribute to weight gain and obesity. Weight management is crucial for overall health.
  2. Cardiovascular Health: Saturated and trans fats, often found in fried and processed foods, can raise levels of LDL cholesterol and increase the risk of heart disease and stroke.
  3. Metabolic Health: A diet high in saturated and trans fats can contribute to insulin resistance, increasing the risk of type 2 diabetes.
  4. Liver Health: Overconsumption of saturated fats may lead to non-alcoholic fatty liver disease (NAFLD), a condition characterized by fat accumulation in the liver.
  5. Inflammatory Response: Some types of fats, particularly trans fats, can promote inflammation in the body, which is linked to various chronic diseases.
  6. Digestive Issues: High-fat diets can cause digestive discomfort, including acid reflux, indigestion, and diarrhea.
  7. Joint Health: Some studies suggest a link between a high-fat diet and increased inflammation, which can contribute to joint pain in conditions like arthritis.
  8. Cognitive Health: Diets high in saturated and trans fats may negatively impact cognitive function and increase the risk of neurodegenerative diseases like Alzheimer’s.
  9. Mood and Mental Health: While omega-3 fatty acids can support mood and mental health, diets high in unhealthy fats may have the opposite effect, potentially contributing to mood disorders.

Maintaining a balanced intake of fats, choosing healthier options first, and consuming saturated and trans fats in moderation are the keys to a healthy diet. A well-balanced diet full of fresh produce, complete grains, lean meats, and healthy fats helps improve overall health. When choosing a diet, one should take into account their health circumstances and dietary requirements.

How to Lessen Fatty Food Preference

You can employ some strategies to decrease your preference for fatty foods. Remember that changing one’s eating preferences may take some time, but it is possible with perseverance and a sensible strategy. 

Gradual Reduction

Sudden, drastic changes in your diet can be challenging to maintain. Start by gradually reducing your intake of fatty foods while introducing healthier alternatives. This approach allows your taste buds to adapt over time.

  • Incorporate Healthy Fats: After gradually reducing unhealthy fats, slowly start to include sources of healthy fats in your diet, such as fats from avocados, nuts, seeds, and fatty fish. These options can satisfy your desire for fats while promoting overall health.
  • Increase Whole Foods: Consume a variety of whole foods such as fruits, vegetables, whole grains, and lean proteins. These provide essential nutrients and can help balance your diet.

Mindful Eating

Pay attention to your eating habits. Eating mindfully can help you recognize feelings of fullness and satisfaction, making it easier to avoid overindulging in fatty foods.

  • Educate Yourself: Learn about the health implications of excessive fat consumption, including its impact on weight, heart health, and overall well-being. Understanding the potential risks can motivate you to make healthier choices.
  • Read Food Labels: Pay attention to food labels to identify and avoid products that are high in saturated and trans fats. Look for products with healthier fat profiles, such as those containing unsaturated fats.
  • Cook at Home: Preparing meals at home gives you control over the ingredients you use. Opt for cooking methods that use less fat, such as grilling, baking, steaming, and sautéing with minimal oil.
  • Substitute Ingredients: Find healthier alternatives for cooking and baking. For example, you can replace butter with applesauce in recipes, use Greek yogurt instead of sour cream, or opt for leaner cuts of meat.

Personal Choices and Habits

  • Manage Stress: Stress and emotional factors can lead to cravings for comfort foods, including fatty options. Practice stress-reduction techniques, like meditation or yoga, to manage emotional eating.
  • Seek Support: Discuss your dietary goals with a healthcare professional, nutritionist, or registered dietitian. They can offer personalized guidance and strategies to lessen your preference for fatty foods.
  • Set Realistic Goals: Make achievable, realistic goals for your dietary changes. Small, sustainable steps are more effective than trying to eliminate fatty foods.
  • Social Support: Let your friends and family know about your dietary goals so that they can offer support and encouragement. Social support can make it easier to stick to your plan.

Keep in mind that it is natural to enjoy the taste of fatty foods, and it’s not about eliminating them from your diet but rather finding a balance that promotes better overall health. Reducing your preference for fatty foods is a gradual process, and patience and consistency are key to long-term success.

LifeDNA’s Fatty Food Preference Report

Fats are essential to the human diet. Indulging in fatty foods now and then is normal but it is always best to strive for a well-balanced diet. LifeDNA’s Preference for Fatty Foods Report can help you understand why you always seem to crave fatty foods – or never seem to crave them, unlike most people. No matter your preference, your genes can tell you why and how your body reacts to dietary changes like adding or reducing fatty food intake.

Fats are not inherently bad. Keep in mind that the source of the fats and your daily intake is important when considering how to keep your preference for fatty foods in check. Whether your objective is to manage your weight, lower your blood sugar levels, or simply keep your body healthy, LifeDNA can help you. Try LifeDNA today.

Summary

  • Although they are sometimes considered undesirable, fats in general are necessary for human nutrition. It all comes down to the kind of fats you eat and where they come from.
  • Foods that are high in fat can be divided into two broad groups: saturated and unsaturated fats.
  • Because they can enhance the flavor and texture of many dishes, saturated fats are typically preferred when it comes to palatability.
  • Due to their benefits for heart health and overall well-being, unsaturated fats are suggested as a part of a balanced diet.
  • Fats are frequently craved by people for a variety of physiological and psychological reasons.
  • People’s preferences for fatty meals are influenced by a variety of factors, including biology, culture, personal psychology, and environmental cues.
  • You can use a variety of tactics to reduce your appetite for fatty foods. 
  • A healthy diet revolves around maintaining a balanced intake of fats, prioritizing healthier options, and ingesting saturated and trans fats in moderation.

References

  1. https://www.nhs.uk/live-well/eat-well/food-types/different-fats-nutrition/
  2. https://www.health.harvard.edu/staying-healthy/know-the-facts-about-fats#:~:text=%22Fat%20helps%20give%20your%20body,your%20body%20absorb%20vital%20nutrients.
  3. https://www.hsph.harvard.edu/nutritionsource/what-should-you-eat/fats-and-cholesterol/types-of-fat/
  4. https://www.sciencedaily.com/releases/2012/02/120203113312.htm
  5. https://www.ncbi.nlm.nih.gov/books/NBK53528/
  6. https://www.frontiersin.org/articles/10.3389/fnut.2021.570401/full
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900072/
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022562/
  9. https://www.nature.com/articles/s41598-023-38988-9#:~:text=Variation%20in%20the%20melanocortin%2D4,occurrence%20of%20obesity15%2C16.
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230842/
  11. https://www.eufic.org/en/healthy-living/article/the-determinants-of-food-choice
  12. https://www.ncbi.nlm.nih.gov/books/NBK206912/
  13. https://www.nhs.uk/live-well/eat-well/food-types/different-fats-nutrition/#:~:text=Eating%20too%20much%20saturated%20fats,liver%2C%20where%20it’s%20disposed%20of.
  14. https://www.healthline.com/nutrition/greasy-food#4.-May-increase-your-risk-of-heart-disease-and-stroke
  15. https://www.health.harvard.edu/staying-healthy/know-the-facts-about-fats
  16. https://www.health.harvard.edu/staying-healthy/know-the-facts-about-fats
  17. https://www.nhs.uk/live-well/eat-well/how-to-eat-a-balanced-diet/eat-less-saturated-fat/
  18. https://www.texasheart.org/heart-health/heart-information-center/topics/14-simple-ways-to-reduce-saturated-fat/
  19. https://www.who.int/news-room/fact-sheets/detail/healthy-diet
  20. https://www.sciencedirect.com/science/article/pii/S0002916523296951?via%3Dihub

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I am so impressed with this service. I have even discussed these recommendations with my health care providers and they are all impressed too! I can’t compare it with other services as I have only tried this but I recommend. Also I think I pulled my genetics in from ancestry too which was super convenient.
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Great source of information I was looking for a platform to make use of my existing raw data from Ancestry. I’m glad I found LifeDNA. I originally took a DNA test to learn about my roots and it’s great to know that my DNA could also play a big role in my health, diet, and even my skin. Overall, all the reports are incredible.
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I got some pretty useful insight that helped me with my diet.
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*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Is Appetite Genetic?

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Is Appetite Genetic?

Date of Content: October 11, 2023
Written by: Avanthika Nityanand
Reviewed by: Maarit Tiirikainen, PhD

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What is Appetite?

Appetite refers to the natural desire to satisfy a bodily need, especially for food. It is a complex mechanism influenced by the central nervous system and hormones, signaling when to eat (hunger) and when to stop eating (satiety).

Genetics of Appetite

Is Appetite Genetic?

The role of genetics in determining appetite and eating behaviors has piqued scientists’ interest, especially in the global obesity epidemic. The interplay between genes, environment, and individual choices paints a multifaceted picture of appetite regulation. 

Every individual has a unique genetic makeup inherited from their parents. This genetic blueprint dictates various aspects of physiology and behavior, including appetite.

Research has identified several genes associated with appetite regulation, hunger, satiety, and specific food preferences. These genetic markers can predispose individuals to certain eating behaviors or metabolic rates, which can, in turn, affect body weight and overall health.

Twin and Family Studies

Findings from twin studies indicate that genes play a significant role in the brain’s control of appetite, highlighting the importance of genetic predispositions in the risk of obesity.

Further, a review paper published in September 2023 observed that traits like satiety responsiveness and food responsiveness had a heritability of 72% and 59%, respectively.

Genes Associated with Appetite

FTO

The FTO gene, which stands for fat mass and obesity-associated gene, has attracted significant attention in obesity research due to its association with body weight. 

A 2009 study examined the influence of the rs9939609 variant of the FTO gene on food intake. The study showed that individuals with the TT genotype consumed less food than AT and AA genotype holders. A 2014 randomized clinical control study showed that individuals carrying the FTO rs9939609 A allele may experience significant food cravings when opting for a low-calorie, high-protein weight-loss diet. A 2014 GWAS also observed a consistent link between FTO gene variants, appetite, and satiety.

MC4R

The MC4R gene encodes the melanocortin 4 (MC4) receptor. The MC4R receptor binds with alpha-melanocyte-stimulating hormone, also known as a-MSH. This receptor is in the hypothalamus of the brain. It plays a pivotal role in regulating food consumption, metabolism, and reproductive actions, among other functions.

In a study involving 18,600 participants from various European nations, the rs17782313 C variant heightened feelings of hunger, the tendency to snack more frequently, and consuming larger quantities of food. Another research, which included 5,724 women, established that this variant was associated with consuming more calories and amount of dietary fat.

Further, a comprehensive review of multiple clinical trials acknowledged the connection between rs17782313 and eating behaviors. So, the presence of the C allele at rs17782313 correlates with obesity and is likely a consequence of unhealthy snacking habits and higher consumption of overall calories and dietary fat.

You may also like: The Genetics of Snacking Behaviour

LEP

The LEP gene codes for leptin, a hormone predominantly produced in adipose (fat) cells. It is crucial in regulating appetite, energy expenditure, and body weight. In other words, leptin is the full signal and opposes ghrelin, the hunger hormone. Together, these two hormones regulate appetite and balance energy expenditure in the body.

Variations in the LEP gene and its receptor (LEPR) have been of interest in numerous studies investigating obesity and eating behaviors. Various SNPs in the LEP gene correlate to body weight, with rs10244329, rs3828942, rs2167270, rs2071045, and rs4731426 being particularly significant.

Broadly, variations that result in heightened leptin production typically correlate with an elevated starting weight, a heightened sense of hunger, and a propensity to regain weight after completing a weight loss regime. The specific alleles associated with high initial leptin levels and increased weight are rs10244329-T, rs3828942-G, rs2167270-A, rs2071045-C, and rs4731426-G.

Non-Genetic Factors Affecting Appetite

While influenced by genetics, appetite is also significantly affected by various non-genetic factors. Here is an overview of some prominent non-genetic determinants that play a role in appetite regulation:

Hormonal Changes

Several hormones directly affect appetite regulation, including ghrelin (often referred to as the hunger hormone), leptin, insulin, and peptide YY. Fluctuations in these hormones due to disease, lifestyle, or other factors can directly influence appetite.

Dietary Habits

What you eat can impact your appetite. For example, protein-rich foods are more satiating than carbohydrate or fat-rich foods. Dietary fiber, found in whole grains, fruits, and vegetables, can also promote feelings of fullness.

Hydration Status

Dehydration can sometimes be mistaken for hunger. Drinking enough water throughout the day can help in regulating appetite.

Sleep Patterns

Lack of sleep can disrupt the balance of hunger-regulating hormones, leading to increased appetite and cravings for energy-dense foods.

Emotional and Psychological Factors

Stress, anxiety, depression, and other emotional states can influence eating habits. Some people may eat more when stressed or depressed (emotional eating), while others may lose their appetite.

Medications

Some medications, including certain antidepressants, antipsychotics, corticosteroids, and antihistamines, can affect appetite.

Physical Activity

Exercise can influence appetite in different ways. It can suppress appetite in the short term but increase hunger as the body works to replenish its energy stores.

Environmental Factors

Exposure to food advertisements, the sight or smell of food, and social eating situations can stimulate appetite even if we’re not physically hungry.

Health Conditions

Various illnesses, from infections to more chronic conditions like hyperthyroidism or cancer, can affect appetite. While some conditions increase appetite, others diminish it.

Gut Microbiota

The gut microbiome, comprising trillions of bacteria residing in our intestines, plays a role in energy metabolism and has been linked to appetite regulation. Disruptions to the balance of these bacteria can influence appetite.

Cultural and Social Factors

Cultural norms, societal pressures, and traditions can dictate when, what, and how much we eat, influencing our appetite and eating habits.

Age

Appetite and dietary needs can change with age. For instance, as people age, metabolic rate decreases, and there might be a reduced need for calories, impacting appetite.

A Note on Prenatal Health and Appetite

Prenatal health and its influence on appetite is a topic of significant research and interest. Maternal health, nutrition, stress levels, and other factors determine the fetal environment during pregnancy. This environment plays a crucial role in shaping the development of various systems, including the appetite regulation system of the fetus. Here is a breakdown of how prenatal health can influence appetite:

Developmental Programming

Fetal programming or developmental programming refers to the theory that exposures during critical windows of fetal development can have long-term consequences on the health of the new individual.  Specifically, prenatal exposures, including maternal diet, stress, and toxins, can cause epigenetic changes in the fetal genome, and these changes are heritable. The consequences of prenatal exposure can include changes in appetite regulation, metabolism, and the risk of obesity and related conditions.

Maternal Nutrition

Maternal undernutrition or overnutrition can lead to appetite dysregulation in children. For example, children of mothers who experienced famine during pregnancy have been shown to have a higher risk of obesity and related metabolic disorders. Similarly, maternal obesity or excessive weight gain during pregnancy can predispose the child to obesity and increased appetite.

Hormonal Influences

Maternal health and diet can influence the hormonal environment of the fetus. For example, changes in maternal levels of leptin, insulin, and ghrelin, which are all involved in appetite regulation, can impact the developing appetite control systems of the fetus.

Placental Function

The placenta is pivotal in nutrient and oxygen delivery to the fetus. Any compromise in its function due to maternal health issues can impact fetal development, including the systems that regulate appetite.

Stress and Cortisol

Maternal stress during pregnancy can elevate cortisol levels, cross the placenta, and impact fetal brain development, including regions involved in appetite regulation.

Gut Microbiota

Emerging research suggests that the maternal gut microbiome during pregnancy can influence the health of an infant’s gut microbiome. It, in turn, can play a role in appetite regulation and metabolic health later in life.

Postnatal Factors

While prenatal health is crucial, postnatal factors like breastfeeding can influence appetite regulation. Breastfed babies might have different appetites and feeding behaviors compared to formula-fed babies.

Summary

  1. Appetite refers to the natural desire to satisfy a bodily need, especially for food.
  2. Our genetic blueprint can influence various aspects of physiology and behavior, including appetite.
  3. Pivotal genes that influence appetite are MC4R, FTO, and LEP.
  4. Several non-genetic factors like hormonal fluctuations, age, sleep, and diet can affect appetite
  5. Prenatal and early infant health can significantly impact an individual’s appetite.

References

Customer Reviews

Christopher Devlin
Christopher Devlin
LifeDNA Customer
Read More
I am so impressed with this service. I have even discussed these recommendations with my health care providers and they are all impressed too! I can’t compare it with other services as I have only tried this but I recommend. Also I think I pulled my genetics in from ancestry too which was super convenient.
Lei'a
Lei'a
LifeDNA Customer
Read More
Great source of information I was looking for a platform to make use of my existing raw data from Ancestry. I’m glad I found LifeDNA. I originally took a DNA test to learn about my roots and it’s great to know that my DNA could also play a big role in my health, diet, and even my skin. Overall, all the reports are incredible.
Shiraz Dole
Shiraz Dole
LifeDNA Customer
Read More
It is crazy how I felt that I had a strong understanding of my bodies needs, but after having my DNA analyzed by the LifeDNA team, I realized that there was so much I still did not know.
Doc Sheila Lim
Doc Sheila Lim
LifeDNA Customer
Read More
I got some pretty useful insight that helped me with my diet.
Previous
Next

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

New GWAS Study: Can Tendency For Vegetarianism Be Genetic?

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New GWAS Study: Can Tendency For Vegetarianism Be Genetic?

Date of Content: October 14, 2023
Written by: Avanthika Nityanand
Reviewed by: Maarit Tiirikainen, PhD

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Background

For millennia, people have chosen not to consume animal flesh for various reasons ranging from religious, ethical, and environmental motivations to health concerns. Some Eastern religious practices like Hinduism and Buddhism often advise against eating meat. Historically, in ancient Greece, followers of figures like Pythagoras and the Orphic tradition had embraced vegetarianism as early as the 6th century BC. During the Renaissance and Enlightenment eras, Europe saw numerous notable individuals adopting vegetarianism. The 19th century saw the establishment of vegetarian societies in both Europe and America.

Recent scientific investigations have demonstrated the health advantages of a vegetarian diet. Such benefits include a reduced risk of ailments such as metabolic syndrome, obesity, lipid disorders, diabetes, cardiovascular diseases, and certain types of cancer. Conversely, some studies suggest potential drawbacks of a vegetarian diet, such as the risk of nutritional deficiencies leading to conditions like anemia, dental erosion, decreased bone density, and certain psychological disorders.

Vegetarianism

Vegetarianism in the World

Despite the growing appeal of vegetarianism, most of the global population still consumes meat. For instance, only about 5% of Americans consider themselves to be vegetarians, according to a 2018 Gallup poll. Similarly, 4% of individuals in the U.K. consider themselves vegans. The numbers are even smaller for people in Austria (3%), Sweden (2%), and Russia (1%). Interestingly, the actual number of strict vegetarians might be even lower. However, past studies have also observed that people who self-identify as vegetarians admit to occasionally eating fish, poultry, or even red meat. 

This inconsistency indicates that while some might aspire to conduct a vegetarian lifestyle, various environmental or biological factors might prevent full adherence. This leads to the intriguing question of whether all of us are or are not biologically equipped to sustain a strictly vegetarian diet in the long term.

Strengthening the argument for a biological predisposition towards food preferences, extensive research suggests a genetic influence on dietary choices. This includes the propensity for meat or vegetable consumption and inclinations towards “healthy” or “unhealthy” eating habits. Such discoveries hint that one’s genetic makeup may partially determine individual dietary preferences or requirements.

Study Summary

Scientific research consistently highlights the inheritability of dietary inclinations. Historically, vegetarianism has existed across different cultures for thousands of years. However, the global population of vegetarians remains relatively small, and the genetic influence on opting for a vegetarian lifestyle remains a mystery. The decision to pursue particular dietary patterns among an ample supply of various food items is a complex balance between the physiological responses to food, how these foods are metabolized, and the perception of taste, all of which have a robust genetic component. In their research, the authors conducted a genome-wide association study (GWAS) to pinpoint loci correlating with strict vegetarianism among participants from the UK Biobank. 

LifeDNA Link: <What Is GWAS?>

In their comparison of 5,324 committed vegetarians to a larger control group of 329,455 individuals, they discovered a specific SNP on chromosome 18 with a strong association with vegetarianism (rs72884519). Additionally, 201 other variants showed a suggestive level of significance. 

Four genes were linked with this SNP, namely TMEM241, RIOK3, NPC1, and RMC1. Researchers also pinpointed 34 other genes potentially influencing vegetarianism. Of these, three – RIOK3, RMC1, and NPC1 – stood out based on gene-level analysis from the GWAS. Intriguingly, some of these genes, such as TMEM241, NPC1, and RMC1, are pivotal in lipid metabolism and brain processes. It suggests that variances in lipid metabolism, coupled with their brain-related impacts, might be the foundation for one’s appeal and capability to thrive on a vegetarian diet. The findings emphasize the genetic underpinnings of choosing vegetarianism and set the stage for subsequent investigations to decode the physiological mechanisms integral to vegetarianism.

Read about the study in more detail here.

Past GWAS on Tendency To Choose Vegetarianism

A 2020 GWAS on 367,198 participants from the UK Biobank discovered a suggestive locus, rs10189138, close to the vaccinia-related kinase 2 (VRK2) gene, significantly associated with vegetarianism. 

Research has shown associations between genetic variants in the VRK2 gene and certain neurological disorders. For instance, variations in the VRK2 gene have been linked to susceptibility to schizophrenia and other psychiatric disorders in some studies. Moreover, the VRK2 protein has been implicated in interacting with proteins that are part of cell signaling pathways, which might influence various physiological processes.

Further analysis revealed that the rs10189138 “T” allele was notably linked to increased height. Additionally, when examining the genetic predictions of vegetarianism against 855 other traits, they found significant genetic correlations between vegetarianism, fluid intelligence, and the age at which menstruation starts. However, for these findings to be conclusive, they emphasized the need for additional research on a separate cohort to verify the GWAS results.

Summary

  • Vegetarianism has deep roots, from ancient Greece to modern health practices.
  • Despite its appeal, most globally still consume meat; e.g., only 3-4% in the US are vegetarians.
  • Genetic research suggests some individuals might be predisposed to vegetarianism.
  • Using GWAS on UK Biobank participants, researchers identified potential genes linked with vegetarianism, such as TMEM241, RIOK3, and NPC1.
  • A 2020 study identified the VRK2 gene’s connection with vegetarianism and additional associated genetic correlations with traits like fluid intelligence.

References

  1. https://wellcomeopenresearch.org/articles/5-291
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323383/
  3. https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/vegetarian-diet/art-20046446
  4. https://www.acc.org/Latest-in-Cardiology/ten-points-to-remember/2023/10/03/02/26/vegetarian-and-vegan-diets
  5. https://www.sciencedirect.com/science/article/pii/S0002916522033640?via%3Dihub

Customer Reviews

Christopher Devlin
Christopher Devlin
LifeDNA Customer
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I am so impressed with this service. I have even discussed these recommendations with my health care providers and they are all impressed too! I can’t compare it with other services as I have only tried this but I recommend. Also I think I pulled my genetics in from ancestry too which was super convenient.
Lei'a
Lei'a
LifeDNA Customer
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Great source of information I was looking for a platform to make use of my existing raw data from Ancestry. I’m glad I found LifeDNA. I originally took a DNA test to learn about my roots and it’s great to know that my DNA could also play a big role in my health, diet, and even my skin. Overall, all the reports are incredible.
Shiraz Dole
Shiraz Dole
LifeDNA Customer
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It is crazy how I felt that I had a strong understanding of my bodies needs, but after having my DNA analyzed by the LifeDNA team, I realized that there was so much I still did not know.
Doc Sheila Lim
Doc Sheila Lim
LifeDNA Customer
Read More
I got some pretty useful insight that helped me with my diet.
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*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

A Full Walkthrough of the LifeDNA Nutrition Report

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A Full Walkthrough of the LifeDNA Nutrition Report

Date of Content: October 19, 2023
Written by: Avanthika Nityanand
Reviewed by: Maarit Tiirikainen, PhD

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The rise of personalized nutrition is heralded as the future of health and wellness. As research delves deeper into understanding how our genes influence our nutritional needs, companies have risen to the challenge. Among the pioneers in this field is LifeDNA. Our Nutrition report perfectly exemplifies how cutting-edge science can translate into actionable consumer insights. This article comprehensively examines the LifeDNA Nutrition report and its significance to personalized wellness.

What is the LifeDNA Nutrition Report?

LifeDNA’s Nutrition report gives you insights into your genetic predispositions related to nutrition. This personalized report highlights how your genes influence your dietary needs,  likelihood for sensitivities, and how you are likely to metabolize various nutrients.

Scientific Basis of the Report

The foundation of the LifeDNA Nutrition report lies in the rapidly expanding fields of nutrigenetics and nutrigenomics. Nutrigenetics and nutrigenomics explore the relationship between genes, nutrition, and health. Scientists can estimate how an individual might react to certain foods or nutrients by examining specific genetic markers. However, it is essential to understand that genetics is just one piece of the puzzle. Lifestyle, environment, and other factors are also significant in health and nutrition.

Key Features of the Report

Nutritional Recommendations 

Our report offers personalized dietary guidelines based on your unique genetic makeup. It can include suggestions on the type of diet that may work best for you, optimal macronutrient ratios, and potential nutrient deficiencies you should watch out for.

Food Sensitivities 

Not everyone processes food the same way. The Nutrition report provides insights into potential food intolerances or sensitivities you might have, such as lactose intolerance or gluten sensitivity.

Insights on Metabolism

Some people metabolize caffeine quickly, while others do not. These metabolism insights help you understand how you process certain substances, which can guide your consumption habits.

LifeDNA Nutrition Report Traits

Carbohydrate Metabolism

We can all admit that carbohydrates (or carbs, as we call them) rule our plates! We try to avoid them as much as possible, but they are too delicious! What if there is a way to eat carbs responsibly? Eat them to enjoy their benefits while minimizing the side effects.

The answer to this question is to know how our bodies break down (or metabolize) carbohydrates. For example, the complex carbs we eat (the yams you could not resist at Thanksgiving) are broken down into simple carbohydrates (mainly glucose or blood sugar) and used by your cells for energy. Some bodies can digest the complex carbs well, while others need more help. 

Understanding your carbohydrate metabolism can help you make informed dietary decisions to maintain consistent energy levels and manage your blood sugar. For example, those who can digest and utilize carbs well could get away with eating more than their slow-digesting friends. Still,  carbs in moderation is a better option than no carbs!

There are known genetic variations that influence carbohydrate digestion.  For example, the AMY1 gene produces salivary amylase, an enzyme in saliva. As you chew food, salivary amylase starts breaking down starches (complex carbohydrates) into maltose and maltotriose, smaller carbohydrate molecules. Studies have shown that individuals with more copies of the AMY1 gene, and consequently higher salivary amylase levels, might be better adapted to digest starchy foods efficiently. 

Saturated Fat Metabolism

We can find plenty of saturated fats in our daily nutrition. From butter and margarine to fatty fish and baked goods, even the most health-conscious of us take in quite a bit of these macromolecules in a week.

Saturated fat metabolism refers to your body’s ability to process and break down saturated fats. Saturated fats influence cholesterol levels and, consequently, cardiovascular health. Optimally, knowing your metabolic response to saturated fats can help you make practical changes to your diet to support heart health. 

For example, APOA2 plays a role in the metabolism of dietary fats, including saturated fats. Specifically, variations in the APOA2 gene can influence your response to saturated fat intake in terms of body weight and obesity risk. 

Sodium Sensitivity

Controlling your sodium intake is one of the most challenging aspects of managing your diet because salt is everywhere! Bread, meat, canned vegetables, salad dressings, sauces, snacks, frozen foods- you name it. Sodium sensitivity refers to variation in blood pressure response to dietary salt intake among individuals. Knowing your sodium sensitivity can help you adjust your salt intake to manage blood pressure better. Maintaining blood pressure within a healthy range can reduce the undue strain on the heart and arteries, ensuring they function as they should. It also prevents hypertension, one of the leading causes of death globally.

The ADD1 gene, which stands for alpha-adducin 1, plays a role in regulating blood pressure. Variants within this gene have been associated with an individual’s sensitivity to dietary salt. In particular, certain genetic variations in the ADD1 gene influence how an individual’s blood pressure responds to salt intake.

Gluten Sensitivity

Gluten sensitivity, often called non-celiac gluten sensitivity (NCGS), is a condition characterized by intestinal and extraintestinal symptoms related to gluten consumption in individuals who do not have celiac disease or wheat allergy. Unlike celiac disease, an autoimmune disorder triggered by gluten ingestion leading to damage in the small intestine lining, gluten sensitivity does not cause this intestinal damage. The symptoms, however, can be similar, including digestive discomfort, fatigue, headaches, and mood disturbances. Identifying gluten sensitivity can guide you in reducing or eliminating gluten from your diet, potentially alleviating digestive or systemic symptoms.

HLA-DQ2 and HLA-DQ8 encode for types of human leukocyte antigen (HLA) molecules found on the surface of cells. They play a crucial role in the immune system function, specifically in presenting peptides (small protein fragments) to immune cells. Due to their strong link with celiac disease, several studies are ongoing to unravel HLAs’  association with gluten sensitivity.

Lactose Intolerance

Lactose intolerance is a digestive condition resulting from our inability to fully digest lactose, a sugar found predominantly in milk and dairy products. The primary reason for this incapability is a reduced level of lactase, an enzyme produced in the small intestine. Lactase is crucial because it breaks down lactose into simpler sugars, glucose, and galactose, which are further absorbed into the bloodstream.

When an individual with lactose intolerance consumes dairy products, the undigested lactose travels to the colon, where it interacts with gut bacteria. This interaction produces gas, leading to various digestive symptoms, including bloating, diarrhea, gas, and stomach cramps. Recognizing lactose intolerance allows individuals to choose lactose-free products or take lactase supplements to prevent symptoms.

The LCT gene encodes the protein lactase in the small intestine. This enzyme is essential for converting lactose from the diet into simpler sugars, glucose, and galactose, which can then be absorbed into the bloodstream. Variations in this gene can increase or decrease the functionality of this protein, affecting our lactose digestibility.

Further Reading: How Genes Influence Risk for Lactose Intolerance

Caffeine Sensitivity

Caffeine sensitivity refers to the varying degrees of response to caffeine. Caffeine is a stimulant in coffee, tea, soft drinks, and many over-the-counter medications. This sensitivity affects how quickly an individual metabolizes caffeine, the amount required to observe its effects, and the type of effects experienced. 

Caffeine can influence heart rate, blood pressure, sleep patterns, and overall alertness. Those highly sensitive to caffeine might experience racing heartbeats, anxiety, jitters, or insomnia, even with a small intake. By being aware of one’s sensitivity to caffeine, one can adjust their intake to ensure they are not adversely affecting their health or sleep patterns. Furthermore, recognizing the level of caffeine sensitivity can help make informed decisions about caffeine consumption, ensuring optimal alertness without undesirable side effects.

Caffeine sensitivity is largely determined by the efficiency of the liver enzyme cytochrome P450 1A2 (CYP1A2) in breaking down caffeine. The CYP1A2 enzyme is responsible for metabolizing about 95% of caffeine consumed.

Weight Change

Weight change refers to the fluctuation in the body weight over a specific period, which can be due to various factors like diet, physical activity, hormonal changes, etc. Monitoring weight changes is essential because maintaining a healthy weight can reduce the risk of chronic diseases such as heart disease and diabetes. Tracking weight can help identify if an individual is receiving the correct nutrients, as sudden weight loss might indicate malnutrition, and rapid weight gain might hint at overeating or hormonal issues. Weight fluctuations can also reflect mental health conditions. For instance, significant weight changes might indicate depression, anxiety, or eating disorders. For those on medications, it is crucial to note weight changes since some drugs can lead to weight gain or loss, or the dosage is dependent on body weight. Athletes and regular exercisers might also want to monitor their weight to ensure optimal performance.

The FTO gene, often called the ‘fat mass and obesity-associated’ gene, has garnered significant attention due to its association with weight and obesity. Variants within the FTO gene are associated with increased body mass index (BMI) and a higher risk of obesity. Individuals with specific genetic variants in the FTO gene may have a higher propensity to gain weight, have a more prominent overall body fat percentage, and may even experience increased hunger or reduced feelings of satiety after eating.

Protein Intake

Protein intake refers to the amount of protein one typically consumes in their diet. Protein is one of the three primary macronutrients, alongside carbohydrates and fats. It plays a critical role in various physiological processes in the body.

Proteins are made up of amino acids, often called the building blocks of our body. Amino acids are essential for constructing and repairing tissues, producing enzymes and hormones, and supporting overall growth and development. Moreover, proteins have a role in immune function, help transport other molecules throughout the body, and can act as an energy source when needed.

The gene most frequently associated with protein intake is the FTO gene. Several variants within the FTO gene are associated with dietary preferences, especially protein-rich foods. Individuals with specific alleles or genetic variants of the FTO gene may have a higher preference for and consumption of protein.

Potential for Peanut Allergy

Peanut allergy is a food allergy where the immune system reacts abnormally to proteins found in peanuts. The allergic reactions can vary from mild symptoms, such as skin rashes or hives, to more severe and potentially life-threatening symptoms, like difficulty breathing, swelling of the throat, and anaphylaxis. Avoiding peanuts and peanut-containing products is crucial for those with the allergy, and they should always carry an epinephrine auto-injector for emergencies.

Potential Shrimp and Peach Allergy

Shrimp allergy is a hypersensitivity reaction of the immune system to specific proteins found in shrimp. Peach allergy is an adverse reaction by the immune system to peaches or food products containing peaches. The reactions can range from mild symptoms such as itching or hives to more severe responses like swelling of the face, throat, or other areas, difficulty breathing, and anaphylaxis.

A 2018 GWAS uncovered HLA-DR and HLA-DQ gene clusters associated with shrimp and peanut allergy. Specific variants within this gene cluster are associated with an increased susceptibility to shrimp and peach allergy.

Sugar Preference

Sugar preference refers to the desire for sweet-tasting foods and beverages. This inclination towards sweetness is believed to have evolutionary origins, as in the wild, sweet foods, like ripe fruits, often indicated they were rich in essential nutrients and safe to consume. However, in our modern environment, where processed foods laden with high sugar content are readily accessible, a strong preference for sugary items can lead to overindulgence. Monitoring sugar preference is essential because excessive sugar intake is associated with various health issues. These include obesity, type 2 diabetes, heart disease, and dental problems. Awareness of your propensity for sugary foods can guide healthier choices and reduce the risk of associated health complications. For example, variations in the GLUT2 gene have been found to have associations with a preference for sugary foods.

Sugar Preference

Sugar preference refers to the desire for sweet-tasting foods and beverages. This inclination towards sweetness is believed to have evolutionary origins, as in the wild, sweet foods, like ripe fruits, often indicated they were rich in essential nutrients and safe to consume. However, in our modern environment, where processed foods laden with high sugar content are readily accessible, a strong preference for sugary items can lead to overindulgence. Monitoring sugar preference is essential because excessive sugar intake is associated with various health issues. These include obesity, type 2 diabetes, heart disease, and dental problems. Awareness of your propensity for sugary foods can guide healthier choices and reduce the risk of associated health complications. For example, variations in the GLUT2 gene have been found to have associations with a preference for sugary foods.

Satiety

Satiety is the feeling of fullness and satisfaction after eating. It acts as a mechanism to prevent overeating by signaling to the brain that enough food has been consumed, reducing the desire to continue eating. Maintaining proper satiety levels is crucial for weight management and overall health. Overeating consistently can lead to weight gain and associated health issues like obesity, heart disease, and type 2 diabetes.

The LEP gene codes for leptin, a hormone predominantly produced in adipose (fat) cells. It is crucial in regulating appetite, energy expenditure, and body weight. Variations in the LEP gene and its receptor (LEPR) have been of interest in numerous studies investigating obesity and eating behaviors.

A 2021 article on the genetic and molecular examined the evidence supporting the influence of the hormones leptin and ghrelin on satiety.

Sensitivity To Bitter Foods

Sensitivity to bitter foods refers to the heightened ability of some individuals to detect and often dislike bitter-tasting compounds in foods. This sensitivity can influence dietary choices, as those who perceive certain foods as excessively bitter may avoid them, even if they are nutritious.

Understanding sensitivity to bitter foods is essential for several reasons. First, it offers insight into individual dietary preferences and aversions, which can impact nutrition and health. For instance, many vegetables high in beneficial compounds might taste bitter to some individuals. If these people consistently avoid such vegetables, they might miss their potential health benefits. 

The TAS2R38 gene primarily influences the ability to taste certain bitter compounds. Variations in this gene can make some individuals more sensitive to specific bitter-tasting chemicals in foods like Brussels sprouts, kale, and other vegetables.

Snacking Behavior

Snacking behavior refers to consuming food and drinks other than main meals – breakfast, lunch, and dinner. The small meals or bites we take between our primary meals can range from a piece of fruit to a handful of chips. The predisposition of some individuals to snack more frequently or prefer certain types of snacks might be genetic. Scientists have recently identified several genes that might influence snacking habits.

Variants of the MC4R gene can influence feelings of satiety, which means individuals with specific mutations might feel hungry sooner after a meal, leading to more frequent snacking.

Appetite

Appetite refers to the natural desire to satisfy a bodily need, especially for food. Understanding appetite is crucial because it affects our daily food intake and energy balance. Overeating or undereating can both have negative health consequences. Overeating can lead to obesity and associated health issues such as diabetes, heart disease, and joint problems. On the other hand, undereating can lead to malnutrition, weakened immune function, and other health problems.

A complex interplay of hormones and neurotransmitters regulates appetite. However, the FTO gene is one of the most studied genes concerning appetite. Variants of the FTO gene are associated with increased hunger, a higher intake of calories, and a preference for high-calorie foods. Individuals with specific FTO gene variants might feel less satiated after eating, increasing the likelihood of snacking, overeating, and obesity.

Preference For Fatty Foods

Preference for fatty foods refers to an inclination or liking for foods high in fat. This can include foods rich in saturated fats, such as butter and fried foods, or unsaturated fats, like nuts and avocados.

The preference for fatty foods is a critical aspect of dietary habits. Fats are a vital diet component for providing essential fatty acids and absorbing fat-soluble vitamins. However, excessive intake of certain fats, especially saturated and trans fats, can increase the risk of heart disease, obesity, and other health issues. Understanding your preference for fatty foods can help you make informed dietary choices, ensuring a balance between enjoyment and health.

The CD36 gene is associated with fat preference. Variations in the CD36 gene can influence the ability to taste and enjoy fatty foods.

Antioxidant Status

Antioxidants are molecules that neutralize free radicals in the body. Free radicals can cause harm if their cellular levels become too high. They come from various sources, including food, medicines, tobacco smoke, radiation, and other biological processes of the body.

Free radicals are unstable atoms that can damage cells, thus contributing to aging and many diseases. Antioxidants neutralize these harmful free radicals, preventing cellular and DNA damage. The body provides antioxidants and sources them from our diet – primarily through fruits, vegetables, and certain types of meat and fish.

Superoxide dismutases (SODs) are special enzymes in all life forms, from bacteria to humans. Their main job is to protect cells from harmful ROS. SOD converts this toxic molecule into two less harmful substances: oxygen and hydrogen peroxide. By doing this, SODs help maintain a balance in our cells and prevent excessive amounts of damaging ROS from accumulating.

Different genes encode the three forms of SOD (SOD1, SOD2, SOD3), and polymorphisms in these genes can influence antioxidant capacity.

Further Reading: How Genes Influence Antioxidant Status

Benefits of the LifeDNA Nutrition Report

a) Personalization: One-size-fits-all dietary guidelines are becoming a thing of the past. With insights from LifeDNA, individuals can tailor their diets to their unique needs.

b) Proactive Health Management: Individuals can make proactive dietary choices to prevent or manage health issues by understanding potential risks and sensitivities.

c) Improved Wellness: Tailored nutrition can increase energy, facilitate digestion, and improve overall well-being.

Why LifeDNA?

LifeDNA has emerged as a prominent option for analyzing 23andMe raw data, owing to a combination of unique offerings and a commitment to personalized wellness. Here is why many regard LifeDNA as the best option for making the most of your 23andMe raw data:

  • Holistic Approach to Wellness: Unlike many other platforms that focus strictly on health-related risks or ancestry, LifeDNA provides a holistic approach. We analyze genetic data to offer personalized optimizations for nutrition (including a personalized grocery list!), skin care, vitamins & supplements, wellness, personality & cognition, and fitness. This range lets users get a complete picture of their wellness needs based on their DNA.
  • Product Recommendations: LifeDNA goes beyond just providing insights. We offer specific product recommendations, skincare ingredients, or supplements tailored to an individual’s genetic profile. This makes our service actionable, allowing users to make immediate changes based on their results.
  • Data Security: LifeDNA places a high emphasis on protecting user data. Our commitment to privacy ensures that users can trust the platform with their sensitive genetic information.
  • User-Friendly Reports: LifeDNA reports are easy to interpret. They are designed to be accessible to the layperson without compromising on the depth and accuracy of the information.
  • Continual Updates: As genetic research evolves, so does LifeDNA’s platform. Users can expect their reports and insights to be updated with the latest scientific findings.
  • Dedicated Research and Development: LifeDNA invests in research to continually refine its algorithms, ensuring the insights provided are based on cutting-edge science.
  • Educational Resources: LifeDNA also provides ample resources for users to understand their genetic makeup better. This education-first approach demystifies the complex world of genetics, making it approachable and actionable for everyone.
  • Scientific rigor: LifeDNA partners with CLIA-certified, CAP-accredited, and HIPAA-compliant laboratories, creating an unmatched commitment to scientific rigor.

Further, if you do not have 23andMe raw data, LifeDNA provides that too. Start your personalized wellness journey with LifeDNA’s state-of-the-art DNA kits here.

References

Customer Reviews

Christopher Devlin
Christopher Devlin
LifeDNA Customer
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I am so impressed with this service. I have even discussed these recommendations with my health care providers and they are all impressed too! I can’t compare it with other services as I have only tried this but I recommend. Also I think I pulled my genetics in from ancestry too which was super convenient.
Lei'a
Lei'a
LifeDNA Customer
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Great source of information I was looking for a platform to make use of my existing raw data from Ancestry. I’m glad I found LifeDNA. I originally took a DNA test to learn about my roots and it’s great to know that my DNA could also play a big role in my health, diet, and even my skin. Overall, all the reports are incredible.
Shiraz Dole
Shiraz Dole
LifeDNA Customer
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It is crazy how I felt that I had a strong understanding of my bodies needs, but after having my DNA analyzed by the LifeDNA team, I realized that there was so much I still did not know.
Doc Sheila Lim
Doc Sheila Lim
LifeDNA Customer
Read More
I got some pretty useful insight that helped me with my diet.
Previous
Next

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

How Genes Influence Snacking Behaviour

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What is Snacking Behavior?

Date of Content: October 10, 2023
Written by: Avanthika Nityanand
Reviewed by: Maarit Tiirikainen, PhD

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What is Snacking Behavior?

Snacking behavior refers to the consumption of food and drinks other than main meals – breakfast, lunch, and dinner. The small meals or bites we take between our primary meals can range from a piece of fruit to a handful of chips.

Why Do People Snack? The Biology

Snacking is an integral part of many people’s dietary habits. But beyond the mere act of consuming food between meals, the biological reasons for snacking provide an intriguing insight into our body’s inner workings and the evolutionary pressures that shaped them.

Hunger and Satiety Mechanisms

The primary biological reason for snacking is due to our body’s hunger and satiety mechanisms. The hypothalamus in the brain plays a critical role in regulating these mechanisms. It responds to signals from hormones like ghrelin, which stimulates hunger, and leptin, which signals satiety. When our energy levels drop, ghrelin production increases, prompting us to seek out food. Conversely, our leptin levels rise after we have eaten, signaling that we have had enough.

Blood Sugar Regulation

Blood sugar levels can also influence snacking. When blood sugar drops, the body seeks a quick source of energy. Carbohydrate-rich snacks, for example, can rapidly boost blood sugar levels, alleviating feelings of hunger or fatigue. But, consistently relying on sugary snacks can lead to peaks and troughs in blood sugar, increasing the urge to snack frequently.

We will discuss this cycle of hunger and satiety in more detail in our blog on the Genetics of Appetite.

Metabolic Rate Variations

Everyone’s metabolism is slightly different from others’. Some people have faster metabolic rates, meaning they burn calories more quickly and might feel hungry more often. In contrast, those with a slower metabolic rate may not feel the need to snack as much.

Evolutionary Perspective

From an evolutionary standpoint, our ancestors did not always have the luxury of regular meals. Snacking, or eating whenever food was available, was crucial for survival. Our modern snacking behavior might be a trace of this “eat when you can” approach, a biological drive to ensure we have enough energy stored for times of scarcity.

Brain Reward System

Beyond pure physiological hunger, the brain’s reward system also plays a role in snacking. Foods, especially those rich in sugar, salt, and fat, can stimulate the release of dopamine, a neurotransmitter associated with pleasure and reward. Over time, we might seek out snacks more to experience the pleasurable feeling associated with certain foods than to satiate hunger.

Section Summary

The biology of snacking is a complex interplay of physiological needs, metabolic processes, and brain chemistry, all influenced by our evolutionary history. Understanding these factors can provide insights into our modern dietary habits and how to make healthier snacking choices.

Genetics of Snacking Behavior

The predisposition of some individuals to snack more frequently or prefer certain types of snacks might be genetic. Scientists have recently identified several genes that might influence snacking habits.

FTO Gene

The FTO gene, often labeled as the “obesity gene,” is one of the most extensively studied genes concerning eating habits and weight management. Variants of this gene are linked to increased calorie intake and a preference for high-calorie foods. Individuals with specific variants of the FTO gene might find it more challenging to resist calorie-dense snacks.

For example, individuals harboring the “A” allele of SNP rs9939609 are less likely to feel satiated or full after eating. This reduced sensation of fullness can lead to increased food intake, potentially contributing to weight gain or obesity over time. 

In a fascinating study published in 2017, researchers observed the consumption of advertised food in children. When subjected to food advertisements, the children consumed an average of 48 kCals more of the recently advertised food than their peers who watched toy advertisements. Interestingly, the consumption of the recently advertised food related to viewing food advertisements increased linearly with every additional FTO risk allele  (“A” allele in SNP rs9939609) present in the individual. 

MC4R Gene

The MC4R gene encodes the melanocortin 4 (MC4) receptor, which interacts with alpha-melanocyte-stimulating hormone (a-MSH). Predominantly found in the brain’s hypothalamus region, this receptor plays a pivotal role in regulating food consumption, metabolic processes, and reproductive behaviors, among other functions. 

Variants of this gene can influence feelings of satiety, which means individuals with specific mutations might feel hungry sooner after a meal, leading to more frequent snacking. In a study involving participants from various European nations, the rs17782313 “C” variant was linked to heightened feelings of hunger, increased snacking tendencies, and the consumption of larger food quantities.

In another study on 5724 women, the risk allele C of rs17782313 was significantly associated with higher intakes of total energy and dietary fat.

In a recent study on 151 Chinese children and their parents, individuals carrying the MC4R rs12970134 “A” variant displayed a heightened inclination towards food and had a higher intake of beverages.

DRD2 Gene

The DRD2 gene stands for dopamine receptor D2 and encodes the D2 subtype of the dopamine receptor. D2 receptor plays a significant role in the neurotransmission of dopamine, a crucial neurotransmitter involved in pleasure, reward, and motivation, among other functions. People with specific variants of the DRD2 gene might derive more pleasure from eating, which can translate to more frequent snacking or a preference for pleasurable, often unhealthy, snacks.

A 2018 study investigated the association of DRD2 Taq1A, Taq1B, and Taq1D gene polymorphisms with eating behavior, the preference/intake frequency/craving of high-fat foods, and obesity in 394 Malaysian adults. Participants carrying the A1 or B1 allele demonstrated a lower Cognitive Restraint score and a higher Uncontrolled Eating score. Additionally, those with the A1/A1 or B1/B1 genotype strongly preferred fast food.  

DRD2 gene variants also influence binge eating disorder, bulimia nervosa, and other substance abuse issues. 

BDNF Gene

The BDNF gene encodes for the brain-derived neurotrophic factor (BDNF) protein. BDNF is a member of the neurotrophin family of growth factors and plays a critical role in the development, maintenance, and plasticity of the central and peripheral nervous systems. Some research suggests a potential connection between BDNF and eating behaviors. Specific variants in the BDNF gene are associated with anorexia nervosa and other eating disorders.

As per a 2021 study comparing patients with anorexia nervosa to healthy controls, the serum BDNF levels in the patients were slightly lower upon admission. However, these levels steadily rose as time progressed, surpassing those in healthy controls at the 2.5-year mark. At discharge, they found a negative correlation between BDNF levels and the severity of eating disorder symptoms.

LEP Gene

The LEP gene codes for leptin, a hormone predominantly produced in adipose (fat) cells. It plays a crucial role in regulating appetite, energy expenditure, and body weight. Variations in the LEP gene and its receptor (LEPR) have been of interest in numerous studies investigating obesity and eating behaviors.

A 2021 article on the genetic and molecular examined the evidence supporting the influence of the hormones leptin and ghrelin on snacking. The article highlighted that individuals with the genotype CT of the rs791607 SNP had a tendency for higher snack consumption.

LEPR Gene

The LEPR gene is associated with the leptin receptor and regulates body weight, energy balance, and appetite. Leptin is a hormone that signals the brain to reduce appetite when energy stores (in body fat) are sufficient.

Early GWAS studies on the LEPR gene established the significant influence of intronic G/A variant rs2025804 on body mass index (BMI). Another study showed that individuals with the risk variant of rs2025804 had the propensity for higher BMI and lower energy. And more recently a 2022 cross-sectional study observed that carriers of the “G” allele of this variant had a tendency for extreme snacking behavior.

PLIN1 Gene

The PLIN1 gene (Perilipin 1) regulates lipid storage and metabolism in adipocytes (fat cells). While its primary function revolves around lipid metabolism, several studies have looked into its potential association with obesity and related eating behaviors, such as snacking. Variations in this gene influence how individuals metabolize and store fat from snacks. It means two individuals consuming the same fatty snack might store that fat differently based on their PLIN1 gene variation.

Section Summary

While genetics can provide insight into our potential snacking behaviors, it’s essential to remember that genes are not destiny. Environmental factors, personal choices, and lifestyle are crucial in shaping our eating habits.

Evolutionary Significance of Snacking

Evolutionary biologists posit that our ancestors, the hunter-gatherers, used to eat multiple small meals throughout the day based on food availability. This approach ensured they had the energy to hunt and gather effectively. Further, the ability to ingest more energy than you expend was beneficial because it allows for energy (fat) storage that may be required in times of food scarcity.

Non-Genetic Factors Influencing Snacking Behavior

Beyond genetics, several non-genetic factors influence our snacking habits:

Emotional State: Stress, boredom, or emotional distress can lead to comfort eating or emotional snacking.

Social Environment: Peer pressure or societal norms can influence snacking. For instance, group settings might make some consume more snacks than alone.

Accessibility: The easier it is to access snacks, especially unhealthy ones, the more likely people are to consume them.

Ideas for Healthy Snacks

Not all snacking is bad. Healthy snacking can provide essential nutrients and keep energy levels stable. Here are some nutritious snack ideas:

  • A handful of nuts.
  • Greek yogurt with berries.
  • Baby carrots with hummus.
  • Apple slices with almond butter.
  • Whole-grain crackers with cheese.

Can Snacking be a Good Habit?

Whether snacking is a ‘good’ habit depends mainly on what and how much you’re eating. Healthy snacks in moderation can balance blood sugar levels, provide essential nutrients, and prevent overeating at mealtimes. However, excessive or unhealthy snacking can lead to weight gain and other health issues.

About the LifeDNA Nutrition Report

The Nutrition Report from LifeDNA offers genetically tailored nutrition insights that can help optimize your wellness. The report delves into your unique genetic predispositions and provides dietary recommendations from macro to micronutrients. Do you have a higher genetic likelihood for lactose intolerance or gluten sensitivity, or how well your body metabolizes caffeine? 

The LifeDNA Nutrition report includes a specific analysis for Increased Snacking Behavior. Get yours here.

Summary

Snacking behavior is an intricate blend of genetics, biology, evolution, and personal circumstances. While our genes and evolutionary history might make us more prone to snack, our choices can determine whether this behavior is beneficial or detrimental to our health. Opting for nutritious snacks in moderation can turn snacking into a health-enhancing habit.

References

Customer Reviews

Christopher Devlin
Christopher Devlin
LifeDNA Customer
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I am so impressed with this service. I have even discussed these recommendations with my health care providers and they are all impressed too! I can’t compare it with other services as I have only tried this but I recommend. Also I think I pulled my genetics in from ancestry too which was super convenient.
Lei'a
Lei'a
LifeDNA Customer
Read More
Great source of information I was looking for a platform to make use of my existing raw data from Ancestry. I’m glad I found LifeDNA. I originally took a DNA test to learn about my roots and it’s great to know that my DNA could also play a big role in my health, diet, and even my skin. Overall, all the reports are incredible.
Shiraz Dole
Shiraz Dole
LifeDNA Customer
Read More
It is crazy how I felt that I had a strong understanding of my bodies needs, but after having my DNA analyzed by the LifeDNA team, I realized that there was so much I still did not know.
Doc Sheila Lim
Doc Sheila Lim
LifeDNA Customer
Read More
I got some pretty useful insight that helped me with my diet.
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*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Is Lactose Tolerance Genetic and What the Research Tells Us

Table of Contents

Lactose Intolerance

Date of Content: August 30, 2023
Written by: Jessica Gayo
Reviewed by: Maarit Tiirikainen, PhD

How many people do you know can’t drink milk or consume anything with dairy because it “doesn’t agree with them”? While the effects of lactose may vary from person to person, they can all agree that lactose intolerance can be uncomfortable, if not downright painful. Nowadays, nutritional genetic testing lets you know if your DNA is more likely to make you lactose intolerant.

What Is Lactose Tolerance?

Lactose intolerance is a condition in which the body cannot fully digest lactose, a sugar found in milk and milk byproducts. This is due to the lack of an enzyme called lactase in the small intestine. As a result of this malabsorption, consuming dairy may cause bloating, gassiness, and diarrhea.

Some people who are lactose intolerant can still consume dairy products in small amounts, while others need to eliminate lactose from their diet completely. It all depends on how badly the symptoms manifest for an individual and what their healthcare provider recommends

Some tests can be done to determine if you are lactose intolerant. The hydrogen breath test and the lactose intolerance test are two of the most common methods healthcare professionals use to determine if an individual has this condition. 

The hydrogen breath test is done by making an individual drink a liquid with plenty of lactose and then measuring the hydrogen levels in their breath afterward. Too much hydrogen means you are lactose intolerant. 

The lactose intolerance test makes you drink a liquid with high levels of lactose, and then your blood will be drawn two hours later to see if glucose levels rose. If glucose remains the same, your body is not digesting lactose, and you are intolerant.

Note that lactose intolerance is not the same as milk allergy. A dairy allergy, or milk allergy, occurs when the immune system overreacts to the presence of proteins in milk. Symptoms may include swelling, breathing problems, and anaphylaxis. Lactose intolerance, on the other hand, is not an allergy because it does not involve the immune system but instead the body’s lack of ability to digest dairy properly.

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Top 7 FAQs About Lactose Intolerance

Today, we’re answering your most frequently asked questions about lactose intolerance

lactose Tolerance

Who Is Most Likely To Have Lactose Intolerance?

While children and younger adults are less likely to be lactose intolerant, they can still develop the condition at a later age. Some health experts even view lactose intolerance as a natural condition of the human body that is related to aging, rather than being a serious condition that needs to be treated. Apart from age, ethnic background may also be a factor for individuals with lactose intolerance.

How Long Do Symptoms of Lactose Intolerance Last?

Symptoms of lactose intolerance usually manifest anytime between 30 minutes to 2 hours after an individual has consumed dairy. They can last for up to 48 hours, depending on how much dairy is consumed.

Does Lactose Intolerance Cause Constipation?

Apart from the typical symptoms of bloating, flatulence, diarrhea, and abdominal pain, a good number of cases of lactose intolerance also have constipation as a symptom. This particular symptom can also be as uncomfortable and painful as diarrhea.

What Happens If You Ignore Lactose Intolerance?

Lactose intolerance is usually harmless if the symptoms are only mild to moderate. Some people have symptoms that are mild enough to be ignored. Thus, they continue to consume dairy in moderate amounts. Lactose intolerance symptoms can vary in severity, but if you suspect you have severe digestive problems, contact your primary care physician immediately.

Can You Reverse Lactose Intolerance?

If lactose intolerance is caused by an underlying condition, getting treatment for the pre-existing disease might help alleviate the symptoms of lactose intolerance, if not completely restore the body’s ability to digest the lactose. However, if lack of lactase causes the symptoms, there is not much an individual can do except manage their symptoms and avoid dairy.

Can Stress Cause Lactose Intolerance?

Researchers have long seen a link between gastric and digestive problems and mental and psychological issues. According to these experts, stomach problems may have little to do with what an individual has consumed and more to do with anxiety, stress, depression, and other psychological conditions. 

What Is The Genetic Basis of Lactose Intolerance In Humans?

Does Genetics Affect Lactose Intolerance?

Yes, lactose intolerance can be influenced by your DNA. For people who consume dairy with genetic lactose sensitivity, there may be excess gas, pain, and other digestive problems. One of the genes we analyze for your lactose tolerance is your MCM6 gene. Discover your genetic likelihood of lactose intolerance today based on DNA with our LifeDNA Nutrition Report.

LCT Gene

Variations affecting the LCT gene, which encodes the lactase enzyme, are the main contributors to lactose intolerance. The enzyme lactase converts lactose, a sugar present in milk and dairy products, into glucose and galactose, two sugars that can be absorbed by the body.

MCM6 Gene

One of the main genetic polymorphisms linked to lactase persistence, or the capacity to digest lactose into adulthood, is the MCM6 gene (SNP rs4988235). On chromosome 2, the MCM6 gene is next to the LCT (Lactase) gene and has regulatory components that affect how the LCT gene is expressed. The rs4988235 SNP, which is specifically positioned in an enhancer region of the MCM6 gene, affects the expression of the nearby LCT gene, which in turn affects lactase synthesis.

 

The “T” allele of rs4988235 is linked to lactase persistence, which means that people who possess this allele are more likely to produce lactase enzyme throughout adulthood and have the capacity to digest lactose without feeling too uncomfortable. Particularly in areas where dairy products have been a dietary mainstay for decades, this allele is frequently discovered in cultures with a history of dairy production and consumption.

 

The “C” allele of rs4988235, on the other hand, is linked to lactase non-persistence, which indicates that people who have this allele experience a decline in lactase synthesis during childhood, resulting in lower lactose digestion and a higher chance of experiencing the symptoms of lactose intolerance.

 

The SNP rs4988235 in MCM6 gene region is the most extensively researched and well-known variation (also known as the LCT T-13910C polymorphism) that impacts lactase expression. It is the main variant that has been thoroughly studied and connected to lactase persistence, while other genetic variations for example  in the MCM6 or LCT genes that affect this feature may exist. Genetic differences connected to lactase persistence may vary throughout groups, and the interaction between these variations can lead to varied levels of lactase activity and lactose tolerance. 

 

An individual’s genotype at the rs4988235 locus can be determined by genetic testing, and this information can reveal whether they are likely to be lactase persistent (and lactose tolerant) or not. However, as heredity only accounts for a small portion of lactose intolerance, environmental variables and cultural customs can significantly affect a person’s actual tolerance to lactose-containing foods.

 

To avoid uncomfortable symptoms, people with the lactase non-persistence SNP may need to limit their dairy intake. Consuming lactose-free dairy products, taking lactase enzyme supplements prior to consuming dairy, or selecting dairy substitutes are all ways to manage lactose sensitivity.

LifeDNA’s Genetic Testing For Food Intolerances

LifeDNA offers a non-invasive test for food tolerance testing. This genetic testing is done via a saliva sample and analyzed by the best scientific labs. 

We also offer a DNA upload option to make it easier for people who have already taken a test to optimize their wellness with LifeDNA. 

Using the latest research for the most accurate results, LifeDNA’s  Nutrition Report will tell you about your body’s response to certain foods based on DNA. This includes your potential food sensitivities, allergies, and intolerances.

How To Manage Lactose Intolerance

A lactose-free diet is more relaxed than it sounds. Fruits, vegetables, meat, poultry, seafood, soy products, whole grains, nuts, and healthy fats can still be fully enjoyed by lactose-intolerant individuals. As a precaution, consult with your doctor before making any major changes in your diet.

Additionally, be extra careful when consuming dairy and dairy-based products. Try the elimination diet and slowly reintroduce dairy products in small amounts into your diet and see how much is too much and what moderate means. You can also find dairy alternatives such as plant-based products and byproducts but make sure you are still getting your daily recommended dose of calcium.

Making dietary and lifestyle decisions that reduce the discomfort and symptoms brought on by consuming lactose-containing foods is essential to managing lactose intolerance. Here are some recommendations for managing lactose intolerance:

  1. Pick out the trigger foods. Keep a list of the foods and drinks that make you feel unwell. While some persons with lactose intolerance are able to handle modest doses of lactose, others must completely avoid it. To find out how much dairy you can tolerate, try out various dairy products.
  2. Select lactose-free dairy products. Lactose-free versions of dairy goods like milk, cheese, yogurt, and ice cream are widely available in grocery shops. These goods have had the lactose removed or broken down, which makes them simpler to digest.
  3. Try dairy substitutes. Investigate non-dairy substitutes such as oat or rice-based lactose-free products, soy milk, coconut milk, and almond milk. To assist satisfy your nutritional needs, make sure to choose alternatives that are fortified with calcium and vitamin D.
  4. Step by step raise intake. Over time, some people who are lactose intolerant can tolerate modest doses of lactose. Incorporate dairy products into your diet gradually to see how your body reacts to them.
  5. Take supplements with the lactase enzyme. You can buy supplements containing the lactase enzyme over-the-counter to aid in the digestion of lactose. Take these before consuming foods or beverages that contain lactose.
  6. Recognize hidden lactose. Unexpected sources of lactose include processed foods, baked products, salad dressings, and some medicines. Keep an eye out for hidden sources of lactose by reading labels carefully.
  7. Speak with your primary care physician or a registered dietitian. Consider speaking with a certified dietitian if you’re unsure how to manage your lactose intolerance or are worried about receiving enough nutrition. They can assist you in developing a healthy, lactose-free diet plan.

Keep in mind that everyone has a different level of tolerance, so what works for one person might not work for another. Finding a strategy that works for your body and lifestyle while yet meeting your nutritional needs is crucial.

Are you thinking about doing genetic analysis to discover what foods work best for you and your unique body? Try LifeDNA today.

Summary

  • Lactose intolerance is a condition in which the body cannot fully digest lactose, a sugar found in milk and milk byproducts. 
  • The lack of an enzyme called lactase in the small intestine causes the malabsorption of dairy, and consuming it may cause bloating, gassiness, and diarrhea.
  • Some tests can be done to determine if you are lactose intolerant. The hydrogen breath test and the lactose intolerance test are two of the most common methods.
  • Lactose intolerance can be influenced by genetics. One of the main genes analyzed for lactose tolerance is the MCM6 gene.
  • Consuming lactose-free dairy products, taking lactase enzyme supplements prior to consuming dairy, or selecting dairy substitutes are all ways to manage lactose sensitivity.

Customer Reviews

Christopher Devlin
Christopher Devlin
LifeDNA Customer
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I am so impressed with this service. I have even discussed these recommendations with my health care providers and they are all impressed too! I can’t compare it with other services as I have only tried this but I recommend. Also I think I pulled my genetics in from ancestry too which was super convenient.
Lei'a
Lei'a
LifeDNA Customer
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Great source of information I was looking for a platform to make use of my existing raw data from Ancestry. I’m glad I found LifeDNA. I originally took a DNA test to learn about my roots and it’s great to know that my DNA could also play a big role in my health, diet, and even my skin. Overall, all the reports are incredible.
Shiraz Dole
Shiraz Dole
LifeDNA Customer
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It is crazy how I felt that I had a strong understanding of my bodies needs, but after having my DNA analyzed by the LifeDNA team, I realized that there was so much I still did not know.
Doc Sheila Lim
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LifeDNA Customer
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I got some pretty useful insight that helped me with my diet.
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*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports and suggestions do not diagnose or treat any health conditions or provide any medical advice. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.

References

  1. https://www.webmd.com/digestive-disorders/lactose-intolerance-or-dairy-allergy 
  2. https://medlineplus.gov/genetics/condition/lactose-intolerance/ 
  3. https://www.mayoclinic.org/diseases-conditions/lactose-intolerance/diagnosis-treatment/drc-20374238 
  4. https://my.clevelandclinic.org/health/diagnostics/12360-hydrogen-breath-test
  5. https://medlineplus.gov/lab-tests/lactose-tolerance-tests/ 
  6. https://kidshealth.org/en/teens/lactose-intolerance.html
  7. https://www.hopkinsmedicine.org/health/conditions-and-diseases/lactose-intolerance
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105309/#:~:text=In%20approximately%2030%25%20of%20cases,often%20accompanied%20by%20abdominal%20pain
  9. https://gi.org/topics/lactose-intolerance-in-children/#:~:text=The%20symptoms%20of%20lactose%20intolerance,symptoms%20until%20later%20in%20life.
  10. https://www.giwebmd.com/blog/2021/7/13/understanding-lactose-intolerance#:~:text=Lactose%20Intolerance%20can%20cause%20serious%20digestive%20issues.&text=If%20left%20untreated%2C%20lactose%20intolerance,in%20the%20stomach%20and%20chest
  11. https://www.mayoclinic.org/diseases-conditions/lactose-intolerance/diagnosis-treatment/drc-20374238#:~:text=In%20people%20with%20lactose%20intolerance,following%20a%20low%2Dlactose%20diet.
  12. https://www.healthline.com/health/can-you-develop-lactose-intolerance#developing-lactose-intolerance
  13. https://www.medicalnewstoday.com/articles/is-lactose-intolerance-an-allergy#is-it-an-allergy 
  14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551416/ 
  15. https://indianapublicmedia.org/eartheats/lactose-intolerance-head.php#:~:text=Researchers%20have%20found%20that%20many,be%20anxious%2C%20stressed%20or%20depressed
  16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401057/
  17. https://gi.org/topics/lactose-intolerance-in-children/#:~:text=The%20symptoms%20of%20lactose%20intolerance,symptoms%20until%20later%20in%20life.

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

DHA Levels Based on DNA: Omega 3 deficiency

DHA Levels Based on DNA: Omega 3 deficiency


If you’re a big fan of fish and other seafood, you have probably looked up their health benefits and already know they are a good source of beneficial nutrients such as Omega-3 fatty acids. 

 

Omega-3 fatty acids have a  wide range of health benefits, including reduced risk of inflammatory diseases and heart disease. One of the  Omega-3 fatty acids is Docosahexaenoic acid, more commonly known as DHA. 

 

Much like Omega-3, DHA can be found in oily fish and has a myriad of scientifically-backed health benefits. On its own, DHA can support your brain function and improve your eye health. This fatty acid can also help your muscles recover faster from exercise, reduce certain types of cancers from developing, and support overall blood circulation. 

How Genetics Can Affect DHA Metabolism

Depending on your DNA, your body may have a reduced or increased metabolism for DHA. This means that your body may be able to synthesize less or more DHA or absorb less or more DHA from your diet and from supplements. 

 

Although your body can produce DHA, it does so in minimal doses via other fatty acids already present. If you want to make your DHA levels higher, taking this fatty acid via food or supplements might help. People commonly take DHA supplements or eat food rich in this fatty acid to lower high levels of cholesterol and other bad fats that might pose a health risk 

 

Genetic testing for deficiency can help reveal your DHA levels LifeDNA offers a wide range of DNA plans to help you get started on your personalized wellness journey.

DHA and Cardiovascular Support

As you may already know, DHA supports overall cardiovascular health. Omega-3 fatty acids, including DHA, can help lower blood pressure. You may probably wonder, “do Omega-3s lower cholesterol?” According to some studies, Omega-3 containing DHA and EPA may also reduce blood cholesterol as an added supplement. 

 

However, it is important to note that DHA supplements cannot and should not replace medication that your physician prescribes for conditions such as high blood pressure and high cholesterol levels.

Symptoms of omega 3 deficiency

It is important that you consume enough Omega-3 fatty acids in order to maintain optimal wellness. 

 

Without adequate DHA in your body, you may be at an increased risk of a compromised immune system, as well as suboptimal pulmonary, endocrine, and cardiovascular health. 

 

In fact, some studies have found that a lack of Omega-3 fatty acids in the body has been associated with several conditions such as:

  • Skin and eye dryness and irritation

  • Depression or depressive episodes

  • Pain and stiffness of the muscles and joints

To boost your DHA levels, optimizing your diet can definitely help! Including more fatty fish such as salmon and cod, as well as nuts high in precursors of DHA can also help boost your DHA levels. 

If you suspect that your body is not able to synthesize or absorb DHA efficiently and effectively, a DNA test for a potential nutrient insufficiency might help. LifeDNA can provide full and comprehensive information on hundreds of unique traits based on your genetic variation. 

 

Genetic testing for vitamin deficiency

Remember, LifeDNA offers a Vitamins Report that provides insights into your body’s potential deficiencies for certain vitamins and minerals, as well as suggestions on how you can improve your lifestyle and supplementation based on your result. Check out our DNA-personalized plans today to learn more. 

 

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Nutritional genetic testing: Understanding your carbohydrate metabolism

 

Nutritional Genetic Testing: Understanding your carbohydrate metabolism

Ever wonder how your body converts the food you eat and the beverages you drink into energy? It takes a village and then some. Metabolism is the complex chemical or metabolic process in which several systems of the body work together to combine calories and oxygen to create and release energy. This converted energy then fuels your body’s basic functions like moving, breathing, blood circulation, and digestion.

 

Understanding how your metabolism works can be synonymous with understanding what your body needs in order to function well. Simply put, a good metabolism equals part of maintaining a healthy body. However, your food intake is not the only thing that affects your metabolism. According to studies, your DNA can also affect your metabolism. Your genetic makeup can tell you how much or how little food intake you need to maximize its conversion into energy.

 

Using genetic testing for nutrition like the one LifeDNA provides can help you know more about your body’s metabolic process based on your genetics. 

Why are carbohydrates important for healthy diet?

While many hear the word “carbs” and just about run away, contrary to popular belief, carbohydrates are not necessarily your enemy. Except when you mostly get them from processed food and drinks with calorie-dense ingredients and less nutritional value, then they can cause health problems in the long run. 

 

In fact, carbohydrates are one of the three macronutrients that the human body needs, along with fat and protein. Carbohydrates play a vital role in your body as they provide several services including acting as an energy source and helping control blood glucose and insulin production. 

 

Carbs don’t just mean pasta and bread, though; it is an encompassing term for all food that contains sugar molecules. These include fruits, vegetables, fibers, legumes, and sugar. Technically speaking, you can’t really “cut out” carbs; you can only choose certain subsets that are the healthier option. 

Genetic testing for nutrition: How DNA can affect carbohydrate metabolism

Digesting carbohydrates can be a different process from one individual to the next. While you may find yourself on the luckier side and have a faster metabolic rate, the same might not hold true for others around you. Some people can ingest large amounts of carbohydrates without the usual side effects such as weight gain and gastrointestinal problems. Others are more sensitive and noticeably gain weight the more carb intake they have. 

 

Carbohydrate metabolism is the complex process in which the body breaks down your carb intake into fuel for energy. There are several types of carbohydrates, thus, the process of breaking them down also differs. 

 

Simple carbohydrates are typically processed sugars that are more easily digested by the body. While some food and drink have natural sugars such as the lactose in dairy and fructose in milk, unnecessary added sugar like corn syrup and sucrose are found on many grocery shelves all over the world. Complex carbohydrates, on the other hand, are digested more slowly and can therefore provide more stable energy for your body in the long run. 

 

Genetic testing for nutritional needs can provide you with more insight into what types of carbohydrates work well with your body based on your genetics. 

Genetic Testing for Personalized Nutrition

If your body is more likely to have a faster metabolism, chances are that your carbohydrate metabolism is also good. Improving your metabolism can be done via proper diet and exercise but it is best to keep in mind that these factors are not the only ones you should consider. Your genetic variation can also tell you how your body processes carbohydrates.

 

Using a personalized nutrition test, your results can tell you how well your body responds to carbohydrate intake. This can help you with your nutrition goal, whether that’s weight management, lowering your blood sugar levels, or simply maintaining a healthy body.

 

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Genetic testing for nutrition and food allergies

Genetic testing for nutrition and food allergies

 

While you may not experience it first-hand, you most likely have witnessed someone or know someone who has allergies. Allergies, in general, are the body’s immune response to certain environmental factors that are otherwise harmless to other people. These triggers are known as allergens and can come in the form of food, dust mites, pollen, animal hair, medication, and others. This immuno-response may vary from mild and manageable to severe and life-threatening.

What is Food Allergy?

 

Food allergens elicit the same response from your immune system if your allergies are triggered. Depending on how allergic you are to a particular food, even the tiniest amount of it can trigger allergic reactions. Food allergies can occur almost immediately and up to 2 hours after an individual has eaten an allergen. 

The Role of Genetics in Food Allergies

As many studies have shown, food allergies can be genetic. Your DNA can impact your likelihood of developing allergies toward peanuts, peaches, and even shrimps. 

 

Genetic testing for nutrition

Thanks to technological advances, people can now get a personalized nutrition DNA analysis to see if they are susceptible to food allergies. LifeDNA can provide a full and comprehensive Nutrition Report that includes insights on food allergies and sensitivities, vitamin deficiencies, and other wellness factors based on your DNA.

Food Allergy Management via Nutritional Genetic Testing

Genetic testing for food allergies can give you the advantage of managing them effectively. 

 

LifeDNA uses the most advanced laboratory technology and the latest research to give you a comprehensive Nutritional Report that includes insights into your food allergies and your likelihood of developing them. Plus, personalized lifestyle optimizations on how you can manage your risk. LifeDNA’s diet and health pack include a full Nutrition Report which includes 40 unique trait reports including:

 

  • Peach Allergy

  • Peanut Allergy

  • Shrimp Allergy

  • Sodium Sensitivity

  • Gluten Sensitivity

  • Sugar Preference

  • Satiety

  • Antioxidant Status

  • …and many more!

If you’re ready to get personalized insights into your DNA, get your Nutrition Report today. 

 

Today, we’ll answer some of the most common questions about certain food allergies:

 

What is peanut allergy?

 

Peanut allergy is one of the most common causes of anaphylaxis. While commonly mistaken for tree nuts, peanuts are actually part of the legume family. They are grouped together with lentils, beans, and soy. A peanut allergy happens when your immune system sees peanut proteins as harmful substances to the body and violently reacts to counter them.

 

Why are peanut allergies so common?

Millions of children suffer from peanut allergies but adults can also have them. While studies show that over 20 percent of children outgrow this food allergy, its effects can still vary from mild to severe. 

Are peanut allergies genetic?

 

One study showed that some parts of the DNA harbor genes that are linked to peanut allergies. This study suggests that these genes pose a significant genetic risk from parent to child, although no conclusive data are available to this day as research continues. 

Peanut Allergy Test

 

Peanut allergies can be detected via a blood test called an immunocap radioallergosorbent (RAST). This test checks the number of immuno-response cells in your blood called antibodies. The higher the antibodies after a controlled food intake, the higher the chances you might be allergic to it.

What is peach allergy?

 

Peaches belong to the family of apricots, cherries, plums, and almonds. Their edible flesh is sought-after because of their sweet-tangy taste. However, some are allergic to peaches. The two types of peach allergies are those that have birch-pollen allergies and those that have non-birch-pollen allergies. 

 

Birch-pollen allergies are caused by the body mistaking peach protein similar to birch protein which causes birch-pollen allergies. This type of protein cannot survive heat and cooking so people with this type can eat cooked or processed peaches. 

 

Non-birch-pollen allergies are caused by eating the flesh and peel which contains a protein present in peaches. They are tough and can survive heat, thus, people with this type of allergy cannot consume peaches in any form.

Peach allergy symptoms

 

Like most food allergies, symptoms of peach allergy can vary from mild to severe. They also include symptoms such as rashes, gastrointestinal problems, and anaphylaxis. Peach allergy may also include symptoms of Oral Allergy Syndrome (OAS) including an itchy mouth, swollen tongue, and scratchy throat.

Peach Allergy Test

 

A peach allergy test can be done via a skin test or blood test. An oral challenge is making the patient take a certain amount of peaches and then test for antibodies. This is only done for those without severe allergic history to peaches. The prick-prick test is also another test; it is done by pricking a lancet into a peach and pricking the same lancet through the individual’s skin. Any adverse reaction will merit a positive result in peach allergies.

What is shrimp allergy?

Shellfish allergy is an allergy to proteins in certain edible marine animals such as crustaceans and mollusks. These include crabs, shrimps, lobsters, squid, oysters, scallops, and other shellfish. Symptoms may also vary from mild to severe.

Shrimp Allergy Test

 

Allergy testing for shrimp allergy can be done the same way as peach allergy testing. A blood test or skin prick tests are two options widely available for shrimp allergy test results. The process is the same; either oral intake of shellfish and then a blood test for antigens or prick shellfish proteins and prick the human skin for any reactions.

When to see a doctor

Food allergies are more common than you might think. If any allergic reaction takes place after eating a certain food, immediately take note of its intensity and take due course of action. See your primary care physician if these symptoms start to manifest more frequently or if they increase in intensity. Emergency cases such as anaphylaxis should be treated immediately and given first-aid medications such as epinephrine injections. 

 

 

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Food sensitivity test: Is gluten bad for you?

Discovering Gluten Sensitivity Through DNA Testing

 

 

Gluten is a kind of natural protein that can be found in wheat, barley, rye, and other grains. It is found in many common food and drinks such as dough, pasta, cereal, beer, and even some types of medicines. Too bad for you if you love pizza and carbonara and turns out you have gluten sensitivity. Even food without naturally occurring gluten can still be contaminated if they are processed in factories that also handle grains or otter food that contains gluten. 


Gluten acts like a binder, giving food a solid bond and that “stretchy” texture. For example, a dough without gluten cannot be kneaded and hand-tossed without a gluten substitute because it can easily rip apart. While a gluten-free diet may need extra planning and paying attention to nutritional labels, it is possible and millions of people have switched to it, even those without gluten sensitivity issues because of the supposed health benefits it can give you.

What is Gluten Sensitivity?

Gluten sensitivity, also sometimes known as non-Celiac gluten sensitivity (NCGS) or gluten intolerance, is when you get sick after eating food or drinks that contain gluten. Symptoms of gluten sensitivity may range from occasionally passing gas to locking yourself up in the toilet for hours. These symptoms can manifest anytime from after eating the gluten-containing food up to several days. Signs of gluten sensitivity may include:

 

  • Gastrointestinal issues such as abdominal pain, diarrhea, and irritable bowel syndrome

  • Bloating and flatulence

  • Unexpected fatigue or brain fog

  • Nausea and vomiting

  • Joint and muscle pain

  • Skin rashes or hives

Genetics and Gluten Sensitivity

Gluten sensitivity can be influenced by your DNA. Since gluten sensitivity is highly related to food allergies, we have analyzed genetic variants that are linked with allergenic reactions including the varied HLA and MYO9B genes.

Benefits of trying out a food sensitivity test

Doing genetic testing with LifeDNA for personalized nutrition can tell you what your gluten needs (or lack thereof) and you can start from there.  A comprehensive nutritional genetic testing on your gluten sensitivities may help with managing your symptoms, identifying potential gluten triggers and avoiding them, as well as reducing your risk of adverse reactions to gluten-containing food and beverages.

LifeDNA can provide a full and comprehensive Nutritional Report that includes gluten sensitivities, food allergies, vitamin deficiencies, and other health factors based on your personalized nutrition test

 

What causes gluten sensitivity?

 

Gluten sensitivity is not to be confused with gluten allergy. Simply speaking, food sensitivities or intolerances affect the digestive system while food allergies are triggered by the immune system. Gluten sensitivity is more common than you might think and affects people of all ages. Some people are born with gluten sensitivity while others develop them with age. 

Diagnosing Gluten Sensitivity

 

To diagnose gluten sensitivity, your primary care physician may ask you to go on a gluten-free diet for a certain period of time, usually for more or less six weeks to rule out Celiac disease or wheat allergies. They might also perform blood tests and skin tests. The former is to see how your immune system will react to wheat proteins and the former is a prick test of wheat protein on an area of your skin for adverse reactions.

Celiac Disease vs. Gluten Sensitivity

Gluten sensitivity vs. Celiac disease has long been lumped together because of the similar symptoms they cause. The two, however, are two different conditions. Celiac disease is an autoimmune condition caused by an abnormal gene wherein the body’s response to gluten is to treat it as if it were an invading virus. With this condition, your tissues eat at your gut (small intestines) whenever you ingest gluten, causing much inflammation and damage to your digestive tract. 

 

While gluten sensitivity can become uncomfortable and sometimes downright painful, it is generally considered a less serious condition compared to Celiac disease. Gluten sensitivity also isn’t caused by abnormal genes, although they can be genetic. 

Can gluten sensitivity cause hair loss?

Gluten doesn’t directly cause hair loss but there are studies that show gluten can influence hair loss. Celiac disease has hair loss listed as a symptom and because gluten is related to this condition, gluten might aggravate the hair loss situation, especially if you have been diagnosed with Celiac disease. 

Can gluten sensitivity cause acne?

While gluten’s relation to Celiac disease can be linked to several skin conditions, there is no scientific evidence that gluten can cause acne. No studies have shown that gluten triggers acne either so you might want to go easy on the spot treatment after eating a burger for dinner. 

 

Plus, did you know that acne can also be influenced by your DNA? Some people are more likely to develop severe acne as compared to others.

If you’d like to discover insights into your skincare and nutrition based on DNA, order your DNA kit today to get started.

 

Managing gluten sensitivity via genetic testing for nutritional needs

Genetic testing for gluten sensitivity can help you prepare and manage your symptoms effectively. LifeDNA can give you a comprehensive Nutritional Report that includes gluten sensitivities and tolerance levels. LifeDNA’s diet and health pack include a full Nutrition Report with every health pack subscription. This bundle includes 40 unique trait reports including:

 

  • Gluten Sensitivity

  • Sodium Sensitivity

  • Carbohydrate metabolism 

  • Saturated fat metabolism

  • Vegetable consumption

  • Sensitivity to bitter foods

  • Antioxidant Status

  • …and a whole lot more!

 

While gluten sensitivity is fairly common, your symptoms still may vary. Knowing the gravity of your gluten sensitivity via genetic testing for nutrition will not only help you manage your condition but also live a life free from the uncomfortable results of indulging in gluten-heavy meals. Always remember to check with your primary care physician before making any major changes in your diet or if you suspect you have severe gluten sensitivities.

 

If you’re ready to discover your gluten sensitivity based on DNA, get LifeDNA’s most powerful Nutrition Report today.

 

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.