Unraveling The Genetics Of Sweet Preference

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Unraveling The Genetics Of Sweet Preference

Date of Content:  November 21, 2023
Written by: Avanthika Nityanand
Reviewed by: Maarit Tiirikainen, PhD



Humans perceive sweet taste through a specialized and complex process that involves taste receptors, taste buds, and signal transmission to the brain.

Sugar Preference

The Sweet Receptor

Sweet taste perception starts in the taste buds, sensory cell clusters on the tongue. Each taste bud contains several taste receptor cells. The key receptors for sweet taste are the G protein-coupled receptors, specifically the TAS1R2 (T1R2) and TAS1R3 (T1R3) subunits, which form the sweet receptor. These receptors are sensitive to various sweet substances, including sugars (like glucose and fructose), artificial sweeteners, and some amino acids.

When you eat something sweet, it binds to the TAS1R2 and TAS1R3 receptor complex. This binding triggers a series of cellular events within the taste receptor cells. Once the sweet molecule binds to its receptor, it activates a G protein called gustducin. This activation leads to a cascade of intracellular events that result in the release of neurotransmitters. These events involve changes in cellular ion channels, leading to the depolarization of the taste cell.

The neurotransmitters released from the taste cells stimulate sensory nerve fibers, which send signals to the brain, particularly to the gustatory cortex responsible for processing taste information. Once these signals reach the brain, it interprets them as a sweet taste. Individual genetic differences can influence this perception, which explains why some people have a stronger preference or sensitivity to sweet tastes than others.

It is also important to note that the perception of sweetness is not just a simple signal from the tongue to the brain. It often involves integration with other senses, especially smell, which can significantly enhance or alter the perception of sweetness.

The understanding of sweet taste perception is crucial in many fields, including nutrition, food science, and medicine, particularly in understanding and managing conditions like diabetes and obesity, where the regulation of sugar intake is vital.

Evolutionary Significance

The evolutionary significance of sweet taste perception lies in its role as a mechanism for survival and adaptation in humans and other animals. Sweetness typically indicates the presence of sugars, a primary and efficient energy source. In the natural environment, especially for early humans and other animals, finding foods rich in sugars was crucial for survival. The ability to detect and prefer sweet tastes helped individuals identify and consume energy-rich foods, especially when food sources were scarce or unpredictable.

Sweet taste is often associated with the ripeness of fruits and other plant foods. Ripe fruits are more energy-dense and generally safer than unripe or overripe fruits, which might be toxic or less nutritious. Therefore, the preference for sweet taste helped early humans to select the most beneficial and least harmful foods.

As humans evolved and spread across different environments, the ability to perceive and enjoy sweet tastes might have played a role in dietary diversification. It allowed early humans to explore and incorporate various new foods into their diets, contributing to their adaptability and survival in diverse habitats.

Breast milk is naturally sweet, which helps in attracting infants to it, ensuring they receive adequate nutrition for growth and development. This innate preference for sweetness helps infants to accept and prefer their mother’s milk or milk substitutes for primary nutrition.

Current Health Challenges

In modern times, the evolutionary preference for sweet tastes poses health challenges. With the widespread availability of artificially sweetened foods and high-sugar food items, this once-beneficial trait can contribute to health issues such as obesity, diabetes, and other metabolic disorders. It represents a case of an evolutionary advantage that, due to changes in environment and lifestyle, has become a disadvantage in the context of modern health.

Genetics Of Sweet Taste Preference


In a study investigating the hereditary aspects of sweet taste preference, researchers focused on a Finnish cohort comprising 146 subjects from 26 families, including a mix of men (32%) and women (68%) ranging in age from 18 to 78 years. Additionally, they provided information about their liking and frequency of consumption of various sweet foods such as chocolate, candy, ice cream, sweet desserts, and pastries. They also completed a questionnaire assessing their craving for sweet foods.

The results revealed significant heritability in several sweet taste perception and preference aspects. The pleasantness rating of the most potent sucrose solution (18.75%) and the intensity rating of PROP showed high heritability estimates of 41% and 66%, respectively. Furthermore, the study found that the overall pleasantness and consumption frequency of sweet foods and the craving for these foods also exhibited considerable heritability (40%, 50%, and 31%, respectively).

Current Research

In 2019, researchers conducted a GWAS on sweet taste perception across three independent samples, all of European ancestry. The first sample consisted of 1757 Australian adolescents, where the perceived intensity of two sugars (glucose and fructose) and two high-potency sweeteners (neohesperidin dihydrochalcone and aspartame) was analyzed. The second sample included 686 U.S. adults, focusing on sucrose’s perceived intensity, sweetness, and preference. The third sample, from the UK Biobank, comprised 174,424 white-British individuals. The study examined the intake of total sugars and sweets.

The findings revealed a strong association between total sugar intake and a single nucleotide polymorphism (SNP) within the FTO gene on chromosome 16. Additionally, the research identified many suggestive associations for each sweet perception and intake phenotype. These results supported the idea that the brain plays a significant role in the perception of sweet taste and sugar intake.

A 2020 GWAS on a large cohort of 12,312 Japanese individuals revealed a significant association between the 12q24 locus and the sweet taste preference. A key finding was the lead variant, rs671, located in the aldehyde dehydrogenase (ALDH2) gene, which is known for its role in alcohol metabolism. This variant is unique in its expression as it is monoallelic (when only one allele is expressed; the other allele is silenced or not expressed) in non-East Asian populations.

A 2021 exploratory GWAS indicated several SNPs associated with sweet taste preference. It included a lead SNP (rs2091718) in the PTPRN2 (Protein Tyrosine Phosphatase Receptor Type N2) gene, where its minor allele correlated with a lower preference for sweet taste. The PTPRN2 gene also emerged as a top-ranked gene in the gene-based GWAS analysis.

Section Summary

In a series of GWAS conducted between 2019 and 2022, researchers explored the genetic basis of sweet taste perception and preference across different populations. These studies collectively enhance understanding of the genetic factors underlying sweet taste perception and preference.

Non-Genetic Factors Affecting Sweet Taste Preference

Non-genetic factors influencing an individual’s preference for sugary foods are multifaceted and involve environmental, psychological, and physiological elements. Understanding these factors is vital as they can significantly impact dietary choices and health outcomes. Here are some critical non-genetic factors affecting preference for sugary foods:

Cultural and Social Influences: Cultural norms and practices significantly help shape food preferences, including liking sugary items. Social factors such as family eating habits, societal norms, and availability influence these preferences. For instance, in cultures where sweet foods are a staple or often used in celebrations, individuals might develop a stronger preference for them.

Early Life Exposure: We form our taste preferences during infancy and childhood. Early exposure to sugary food items can lead to a preference for such tastes later in life. Breastfeeding patterns, the timing of introducing solid foods, and the variety of foods offered during early childhood can all influence this.

Emotional and Psychological Factors: Emotional states like stress, sadness, or even happiness can influence food choices, often leading to increased consumption of sugary foods due to their comforting or rewarding nature. Additionally, psychological factors such as food reward sensitivity, eating disorders, and habitual behaviors can also play a role.

Economic Factors: Socioeconomic status can influence food preferences and choices. For instance, in some settings, high-calorie, sugar-rich foods are more affordable and accessible than healthier options, leading to higher consumption among lower-income groups.

Advertising: Exposure to food advertising, especially for sugary products, can significantly influence preferences and consumption patterns, particularly among children and adolescents.

Education: Awareness and education about nutrition and health can influence food choices. Individuals with higher nutrition literacy might be more likely to understand the health implications of consuming sugary foods and thus moderate their intake.

Physiological Factors: Physiological factors include individual differences in taste perception not attributed to genetic factors, such as variations in taste bud sensitivity due to age or health conditions. Additionally, hormonal changes can affect taste preferences and cravings for sugary foods.

Habit and Convenience: Lifestyle and daily routines can influence food preferences. For instance, a busy lifestyle and sleep deprivation might lead to increased consumption of convenient, often sugar-rich, processed foods.

Section Summary

While genetics play a crucial role in determining sweet taste preferences and the liking for sugary taste, these non-genetic factors are equally significant in shaping dietary habits and preferences. They offer potential intervention points for nutritional education and public health strategies to reduce excessive sugar consumption.

Healthy Ways To Satisfy Sweet Cravings

Satisfying sweet cravings in a healthy way involves choosing options low in added sugars, artificial sweeteners, and unhealthy fats. Ideally, a sweet food item, if preferred, must also contribute beneficial nutrients to your diet. Here are some healthy ways to satisfy your sweet tooth:

  1. Fresh Fruit: Nature’s candy is fruit. It is naturally sweet and provides vitamins, minerals, and fiber. Berries, apples, pears, or tropical fruits like mango and pineapple are great choices.
  2. Dark Chocolate: A piece of dark chocolate, especially at least 70% cocoa, can be a rich, satisfying way to quell a sweet craving with the added benefit of antioxidants.
  3. Greek Yogurt with Honey or Fruit: Greek yogurt is high in protein and lower in sugar than regular yogurt. Adding a bit of honey or fresh fruit can make it a deliciously sweet and healthy treat.
  4. Smoothies: Blending fruits like bananas, berries, or peaches with ice, yogurt, or milk (dairy or plant-based) can create a sweet, nutritious smoothie.
  5. Homemade Trail Mix: Combine nuts, seeds, and a small amount of dried fruit or dark chocolate chips for a satisfying, nutrient-rich snack.
  6. Baked Fruit: Baking fruits like apples or pears with a sprinkle of cinnamon can bring out their natural sweetness.
  7. Nut Butter: Spread almond or peanut butter on whole-grain toast or apple slices for a satisfyingly sweet and savory combination.
  8. Healthy Baking Substitutes: When baking, use healthier substitutes such as apple sauce, mashed bananas, or dates instead of sugar to sweeten your recipes.
  9. Frozen Grapes or Banana Slices: These can taste like bite-sized popsicles and are refreshing.
  10. Oatmeal: Sweeten your oatmeal with fruits, cinnamon, or a drizzle of honey instead of sugar.

Remember, moderation is vital, even with the healthier options. These alternatives are much better than high-sugar, high-fat sweets. But enjoy them in sensible portions.

About The LifeDNA Nutrition Report

Do you have a higher genetic likelihood for lactose intolerance or gluten sensitivity, or how well does your body metabolize caffeine? The Nutrition Report from LifeDNA offers genetically tailored nutrition insights that can help optimize your wellness. The report delves into your genetic predispositions to food intolerances and provides dietary recommendations for macro and micronutrients. 

The LifeDNA Nutrition report includes a specific analysis of Sugar Preference and preference for Sugary Drink Consumption. Get yours here.


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*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

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