How Do Genes Influence Your Vitamin B5 Needs?

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How Do Genes Influence Your Vitamin B5 Needs?

Date of Content: November 13, 2023
Written by: Harvey Talento
Reviewed by: Maarit Tiirikainen, PhD

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What is Vitamin B5?

Vitamin B5, also known as pantothenic acid, is an essential nutrient present in various foods and supplements. It supports the body in producing coenzyme A (CoA) and acyl carrier protein, crucial for tasks such as breaking down fats. During consumption, the majority of Vitamin B5 comes in diverse forms, but the body converts them into a straightforward form that is usable.

Vitamin B5 Levels

What Does Vitamin B5 Do to Your Body?

Vitamin B5 serves many essential functions in the body, contributing to overall wellness. Here are some key roles that vitamin B5 plays:

  • Making Coenzyme A 

Vitamin B5 plays a role in making coenzyme A, a key player in various metabolic pathways. Coenzyme A is instrumental in the synthesis of fatty acids, facilitating the conversion of dietary components into essential fats and cholesterol. 

Additionally, it contributes to the production of sphingosine, a lipid-like molecule that functions in transmitting chemical messages within the body’s cells. Notably, the liver relies on coenzyme A to metabolize certain drugs and toxins safely.

  • Supporting a Good Digestive System

Maintaining a good digestive system is crucial for overall well-being, directly impacting nutrient absorption and utilization. Vitamin B5 plays a significant role in this process, assisting in the use of other essential vitamins, especially vitamin B2.

The collaboration between these vitamins optimizes the efficiency of nutrient absorption, fostering optimal digestive function. Through its support for the digestive system, Vitamin B5 helps guarantee that the body can effectively extract and use nutrients, contributing to overall well-being and vitality.

  • Skin Moisturization and Wound Healing

The importance of skin moisturization and efficient wound healing cannot be overstated. Vitamin B5 has demonstrated its efficacy in both these aspects. Studies indicate that Vitamin B5 serves as a potent moisturizer for the skin, promoting hydration and skin wellness.

Furthermore, research has shown promising results in using Vitamin B5 as a dietary supplement for facial acne, with a significant reduction in total lesion count over a 12-week period. While these findings are encouraging, further clinical trials are warranted to validate the results.

  • Cholesterol and Triglyceride Regulation

Maintaining optimal cholesterol and triglyceride levels is crucial for cardiovascular wellness. Vitamin B5 has been implicated in potentially contributing to the regulation of cholesterol and blood triglyceride levels, as suggested by some studies. 

However, it is imperative to highlight that any approach to managing cholesterol levels should only be undertaken under medical supervision. Vitamin B5’s potential role in this regard emphasizes the interconnectedness of nutrition and cardiovascular wellness, highlighting the need for a comprehensive and medically guided approach to address lipid profile imbalances.

The roles of vitamin B5 are crucial in maintaining overall well-being. Therefore, it is important to balance its levels in our bodies to keep us in top shape.

Genetics of Vitamin B5 Levels

Understanding the genetics of vitamin B5 levels holds the promise of personalized nutrition and targeted wellness interventions. By identifying specific genetic variations related to vitamin B5 metabolism, individuals can receive tailored dietary suggestions and interventions to optimize their nutrient levels.

The following are some genes that play a role in Vitamin B5 levels.

PANK 2

This gene encodes Pantothenate kinase 2, an enzyme that catalyzes the first step of vitamin B5 (pantothenic acid) metabolism, converting it to 4’-phosphopantothenic acid. This enzyme is inhibited by coenzyme A, a derivative of vitamin B5 that is essential for many biochemical reactions.

SLC5A6

The SLC5A6 gene provides instructions for making a protein called the sodium (Na+): multivitamin transporter (SMVT). This protein acts as a carrier that helps bring important vitamins, including vitamin B5, into our cells.

When there are changes in this gene, such as when the SNP rs1395 is present, it can influence the function of the SMVT protein. A study suggests that individuals carrying the A allele of rs1395 may experience variations in how their cells absorb and handle vitamin B5.

It is important to note that while information on genetic factors affecting vitamin B5 levels provides valuable insights, it is just one aspect of a holistic approach to wellness. Lifestyle factors, environmental influences, and overall wellness assessments should also be considered to comprehensively understand an individual’s well-being.

Non-Genetic Factors Influencing Vitamin B5 Levels

As we investigate the role of vitamin B5 in our bodies, it’s essential to recognize that genetic factors aren’t the sole influencers. External elements, such as diet, medications, stress, and age, play pivotal roles in shaping the intricate dynamics of vitamin B5 metabolism.

Diet

A diet that is low in vitamin B5 or high in processed foods that contain little or no vitamin B5 may lead to deficiency. Conversely, a diet that is rich in vitamin B5 or fortified with vitamin B5 may increase the levels of this vitamin in the body.

Medications

Some medications may interfere with the absorption or metabolism of vitamin B5, including antibiotics, oral contraceptives, anticonvulsants, and cholesterol-lowering drugs. These medications may reduce the levels of vitamin B5 in the body or increase the requirement for this vitamin.

Stress

Stress may increase the demand for vitamin B5, as it is involved in the production of stress hormones, such as cortisol and adrenaline. Stress may also affect the intestinal microbiota, which may alter the production of vitamin B5 by the bacteria.

Age

Age may affect the levels of vitamin B5 in the body, as older adults may have lower absorption and higher excretion of vitamin B5 compared to younger adults. Older adults may also have a lower intake of vitamin B5 from the diet or lower production of vitamin B5 by intestinal bacteria.

Keeping our vitamin B5 levels in balance is easier when we pay attention to how we treat our bodies. Being aware of our habits and surroundings helps us make choices that support good vitamin B5 levels, which is important for our overall well-being.

How to Optimize Vitamin B5 Levels Naturally

Exploring dietary avenues to optimize vitamin B5 levels naturally reveals a spectrum of nutrient-rich foods. The following are some items to consider:

Organ Meats

Among the most potent sources, organ meats (liver, kidney, and heart) deliver a substantial dose of vitamin B5, boasting up to 8.3 mg per 3 oz serving. Beyond vitamin B5, they are nutritional powerhouses, offering a symphony of other essential B vitamins, iron, and protein for overall bodily functions. Incorporating organ meats into your diet provides a comprehensive nutrient profile vital for optimal well-being.

Mushrooms

Mushrooms, particularly when dried, emerge as a concentrated source of vitamin B5, providing a remarkable 21.9 mg per 100 grams. Beyond their B5 content, mushrooms contribute vitamin D for the bones, selenium with antioxidant properties, and a medley of antioxidants that support overall immune function. Including a variety of mushrooms in your meals enhances flavor and enriches your diet with a diverse range of nutrients.

Sunflower Seeds

Enjoying sunflower seeds as a snack introduces a delightful way to boost your vitamin B5 intake, offering 6 mg per 3 oz serving. These seeds go beyond B5, providing vitamin E for the skin, magnesium for muscle and nerve function, and good fats contributing to cardiovascular well-being. Incorporating sunflower seeds into your diet satisfies your taste buds and nourishes your body with a blend of essential nutrients.

Avocados

Avocados, known for their creamy texture, contribute 2 mg of vitamin B5 per fruit. Alongside vitamin B5, avocados offer a rich array of nutrients, including vitamin K for blood clotting and the bones, folate crucial for cell division, potassium for heart wellness, and monounsaturated fats that support a good cardiovascular system. Integrating avocados into your meals adds a delicious and nutrient-dense element to promote overall wellness.

Salmon

Salmon, a fatty fish, provides 1.6 mg of vitamin B5 per 3 oz serving. Beyond vitamin B5, salmon is renowned for its omega-3 fatty acids; promoting heart wellness, vitamin B12 which is crucial for nerve function, and selenium which has antioxidant properties. Including salmon in your diet contributes to your B5 intake and delivers a bounty of essential nutrients that support various bodily functions, making it a valuable addition to a nutritious diet.

Other foods containing vitamin B5 include eggs, dairy products, whole grains, legumes, broccoli, and fortified cereals. While vitamin B5 supplements are available, obtaining nutrients from natural food sources is generally suggested.

Dietary Supplements

Vitamin B5 can also be taken through dietary supplements. These may contain only Vitamin B5, combined with other B-complex vitamins, or as part of some multivitamin/multimineral products.

About the LifeDNA Report

LifeDNA’s Vitamins & Supplements Report is your personalized roadmap for optimizing Vitamin B5 levels based on your unique genetic traits. This report delves into your genetic predispositions, offering tailored dietary recommendations to enhance your Vitamin B5 levels.

Uncover insights into your genetic tendencies related to Vitamin B5 levels, and take the first step toward achieving optimal wellness with the LifeDNA Vitamins & Supplements Report. 

Start your journey to personalized well-being today!

Summary

  • Vitamin B5, or pantothenic acid, crucial for many metabolic processes, is absorbed through active transport mechanisms and is found in both plant and animal food sources.
  • Vitamin B5 supports coenzyme A synthesis which is needed for fatty acid and cholesterol production, aids digestion, and shows potential benefits on the skin and cholesterol regulation.
  • The PANK2 gene initiates vitamin B5 metabolism.
  • External factors such as diet, medications, stress, and age significantly impact vitamin B5 levels, emphasizing the importance of a balanced lifestyle.
  • Dietary sources rich in vitamin B5, including organ meats, mushrooms, sunflower seeds, avocados, salmon, and various other foods, provide a holistic approach to maintaining optimal vitamin B5 levels for overall well-being.

References

Customer Reviews

Christopher Devlin
Christopher Devlin
LifeDNA Customer
Read More
I am so impressed with this service. I have even discussed these recommendations with my health care providers and they are all impressed too! I can’t compare it with other services as I have only tried this but I recommend. Also I think I pulled my genetics in from ancestry too which was super convenient.
Lei'a
Lei'a
LifeDNA Customer
Read More
Great source of information I was looking for a platform to make use of my existing raw data from Ancestry. I’m glad I found LifeDNA. I originally took a DNA test to learn about my roots and it’s great to know that my DNA could also play a big role in my health, diet, and even my skin. Overall, all the reports are incredible.
Shiraz Dole
Shiraz Dole
LifeDNA Customer
Read More
It is crazy how I felt that I had a strong understanding of my bodies needs, but after having my DNA analyzed by the LifeDNA team, I realized that there was so much I still did not know.
Doc Sheila Lim
Doc Sheila Lim
LifeDNA Customer
Read More
I got some pretty useful insight that helped me with my diet.
Previous
Next

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Understanding the Genetics Behind Your Glomerular Filtration Rate

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Understanding the Genetics Behind Your Glomerular Filtration Rate

Date of Content: November 8, 2023
Written by: Jess Gayo
Reviewed by: Maarit Tiirikainen, PhD

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Overview

What is the Glomerular Filtration Rate?

If you’ve ever had your blood drawn for tests, you would have noticed many components in the results. One of them is your body’s (estimated) glomerular filtration rate or eGFR. Glomerular filtration is a fundamental process within the human kidneys, playing a crucial role in the body’s ability to regulate fluid balance and eliminate waste products. 

Situated in the renal corpuscle, the glomerulus is a network of tiny blood vessels tasked with filtering the blood to form urine. This filtration process, driven by the pressure gradient across the glomerular capillaries, allows essential substances like water, electrolytes, and small molecules to pass through the filtration barrier while retaining larger molecules like proteins and blood cells.

Fundamentally, glomerular filtration is an intricately calibrated system that preserves homeostasis by guaranteeing the removal of metabolic waste products without jeopardizing essential elements required for physiological processes. One of the most important markers of kidney function is the glomerular filtration rate (GFR), which measures the amount of fluid filtered by the glomerulus in a given amount of time. 

Since differences in the genes linked to this process can affect an individual’s vulnerability to kidney disorders, understanding the genetic foundations of glomerular filtration has become a focus of nephrology studies.

Glomerular filtration is essentially the cornerstone of kidney function, demonstrating the complex interactions between filtration barriers, blood arteries, and genetic factors in the coordination of this essential physiological function.

Glomerular Filtration Rate

Why is Glomerular Filtration Important?

The preservation of the body’s internal environment and general health depend critically on glomerular filtration. This process, which takes place in the kidneys and is the main means of eliminating waste and regulating fluid balance, is essential in preventing the build-up of toxic compounds in the blood. 

Glomerular filtration maintains the body’s delicate balance by allowing just those vital elements—water, electrolytes, and tiny molecules—to flow through while trapping larger molecules and cells.

One important metric for evaluating renal function is the GFR. When the GFR deviates from the normal range, it may be a sign of possible kidney disease. This information can help with early renal problem identification and prompt action. Moreover, individual differences in kidney function and susceptibility to renal disorders are influenced by the hereditary components of glomerular filtration. 

Comprehending these hereditary foundations is essential for customizing therapeutic strategies and creating focused treatments, ultimately improving our capacity to treat and avoid kidney-related illnesses.

What Affects Glomerular Filtration Rate?

Glomerular filtration rate (GFR) is influenced by various factors, including blood pressure, blood volume, and the permeability of the filtration barrier. Conditions such as hypertension can alter the pressure within the glomerular capillaries, impacting GFR. Changes in blood volume affect the rate at which blood is filtered in the kidneys. 

Additionally, alterations in the permeability of the glomerular filtration barrier, influenced by factors like inflammation, can impact GFR. Hormonal regulation, especially through the renin-angiotensin-aldosterone system, also plays a crucial role. 

Genetic Factors

Genetic markers associated with glomerular filtration rate (GFR) provide valuable insights into the individual variability in kidney function and susceptibility to renal diseases.

Several genetic factors contribute to the regulation of GFR, influencing the efficiency of the glomerular filtration process. While the genetic landscape of GFR is complex and involves numerous genes, some key markers have been identified through research.

SHROOM3 Gene

The SHROOM3 gene is involved in the regulation of cell shape and structure. Genetic variants in SHROOM3, such as the SNP rs17319721, have been linked to an increased risk of Chronic Kidney Disease (CKD) and reduced GFR. This gene is thought to play a role in the maintenance of the glomerular filtration barrier and overall kidney function.

APOL1 Gene

The APOL1 gene has been implicated in kidney disease susceptibility. Variants in this gene are associated with an increased risk of chronic kidney disease (CKD) and end-stage renal disease (ESRD). These variants may impact the permeability of the glomerular filtration barrier, influencing GFR.

UMOD Gene

The UMOD gene encodes uromodulin, a protein expressed in the kidneys. Uromodulin plays a role in regulating water and electrolyte balance. Genetic variations (such as SNP rs11864909) in UMOD have been linked to changes in GFR. Certain UMOD mutations are associated with a higher risk of CKD, emphasizing the gene’s relevance to kidney function.

EGFR Gene

The epidermal growth factor receptor (EGFR) gene is involved in cell growth and differentiation. Variations in this gene have been linked to changes in GFR, impacting renal function. EGF is part of the complex interplay of growth factors influencing the maintenance of glomerular structure and function.

NOS3 Gene

Nitric oxide synthase 3 (NOS3) produces nitric oxide, a molecule involved in blood vessel dilation. Genetic variations in NOS3 have been associated with endothelial dysfunction and altered renal blood flow, potentially impacting GFR. Dysfunction in nitric oxide signaling can contribute to the development of renal disorders.

LifeDNA’s GFR Genetic Markers

A study with 432 participants with Chronic Kidney Disease (CKD)identified eight gene variants (SNPs) linked to CKD risk, including CX3CR1, MTTP, PIP5K1B, APOA5, BRAP, SPATA5L1, and MCP1. Notably, specific SNPs in BRAP and SPATA5L1 were significantly associated with the eGFR. Furthermore, a genetic risk score (GRS) using the 8 SNPs was developed, and it could indicate up to a 17% higher risk for CKD. 

Understanding genetic factors for GFR and CKD is crucial for personalized medicine and targeted interventions in the realm of nephrology. Genetic testing and research continue to unveil the intricate relationship between genetic variants and renal function, paving the way for advancements in the diagnosis, treatment, and prevention of kidney diseases.

Environmental Factors

Numerous non-genetic factors can affect the glomerular filtration rate (GFR), a crucial measure of kidney function. The intricate interplay of physiological systems that control renal function can also be influenced by these extrinsic factors. For the purpose of understanding kidney health and developing strategies to maintain optimal filtration rates, it is imperative to appreciate how environmental influences affect GFR.

Hydration Status

Drinking adequate amounts of water is essential to preserving GFR. Dehydration can cause blood volume to drop and blood viscosity to rise, which can change the pressure inside glomerular capillaries. This pressure change might affect the rate of filtration, which highlights how crucial it is to stay properly hydrated for the best possible kidney function.

Blood Pressure

Systemic blood pressure is a major factor in the control of GFR. Over time, glomerular capillaries may sustain damage from hypertension, or high blood pressure, which could result in a reduction in GFR. On the other hand, decreased blood pressure can lower the glomerulus’s filtration pressure, which would be detrimental to GFR.

Blood Glucose Levels

High blood sugar, which is a symptom of diabetes, can affect GFR and cause renal injury. Reduced GFR is frequently caused by diabetic nephropathy, a kidney condition associated with diabetes. Maintaining blood glucose control is essential for avoiding problems associated with diabetes, such as reduced kidney function.

Medications and Toxins

Nephrotoxic effects can be caused by some drugs and environmental pollutants, which can affect GFR directly. Substances that can impair renal function include exposure to heavy metals, some medicines, and nonsteroidal anti-inflammatory medications (NSAIDs). Maintaining GFR requires reducing exposure to nephrotoxic chemicals and being aware of the negative effects of medications.

Dietary Habits

Dietary choices influence GFR through their impact on blood pressure and metabolic factors. High-sodium diets can contribute to hypertension, affecting GFR. Additionally, excessive protein intake may increase the glomerular filtration load, potentially straining the kidneys over time.

Physical Activity

Frequent exercise is linked to cardiovascular health, which has an impact on GFR. Exercise supports good kidney function by promoting healthy blood pressure and cardiovascular health in general. Dehydration can result from strenuous physical activity without adequate hydration, which may have an impact on GFR.

Infections and Inflammation

Infections and inflammatory conditions can affect GFR by triggering immune responses and altering the permeability of the glomerular filtration barrier. Inflammatory kidney conditions, such as glomerulonephritis, can lead to decreased GFR.

Temperature and Climate

Environmental temperature can impact fluid balance and, consequently, GFR. Extreme heat can lead to increased fluid loss through sweating, potentially causing dehydration and affecting renal blood flow.

Altitude

Changes in altitude can influence oxygen levels in the blood and systemic blood pressure, which may impact GFR. Individuals living at higher altitudes may experience adaptations in renal function to compensate for lower oxygen levels.

Stress

Chronic stress and the associated activation of the sympathetic nervous system can lead to changes in blood pressure and systemic vascular resistance, potentially affecting GFR. Stress management strategies are crucial for overall health, including kidney function.

Numerous environmental and lifestyle factors that impact general health and well-being can have an impact on the eGFR. Maintaining kidney function and stopping the onset or progression of renal diseases need effective management of these outside factors.

Maintaining optimal GFR requires a comprehensive approach to health that includes blood pressure management, a balanced diet, lifestyle choices, and adequate hydration.

Is the Glomerular Filtration Rate Reversible?

Although some elements that affect GFR, including blood pressure fluctuations or dehydration, can be corrected with the right treatments, the GFR itself cannot be changed.

Dehydration is one of the factors that might cause a transient drop in GFR because it changes the filtration pressure and blood volume. Rehydrating and treating the underlying cause are frequently sufficient to return GFR to normal. Similar to this, some drugs or lifestyle modifications may have a favorable effect on GFR.

However, structural damage to the kidneys in situations of chronic kidney disease (CKD) or other persistent renal diseases may result in a persistent decline in GFR that is not entirely reversible. In these situations, the main goals of treatment are usually to control the underlying illness, reduce the rate at which the disease progresses, and treat the symptoms.

Some influences on GFR are reversible through appropriate measures but the overall GFR is a dynamic parameter influenced by various factors, and its reversibility depends on the underlying cause and the extent of structural damage to the kidneys.

Ways to Maintain Good Glomerular Filtration Rate

Maintaining a healthy Glomerular Filtration Rate (GFR) is essential for kidney function and overall well-being. While individual factors can vary, there are several lifestyle modifications and habits that may contribute to improving GFR and supporting optimal kidney health.

Hydration

Adequate hydration is crucial for optimal kidney function. Staying well-hydrated helps maintain blood volume and supports the kidneys in efficiently filtering waste products. Water intake should be adjusted based on individual needs, considering factors like climate, physical activity, and overall health.

Balanced Diet

Adopting a balanced and nutrient-rich diet is vital for kidney health. Focus on consuming a variety of fruits, vegetables, whole grains, lean proteins, and healthy fats. Limit salt intake, as excessive sodium can contribute to hypertension and impact GFR. Additionally, moderate protein intake is recommended, as very high protein diets may strain the kidneys.

Regular Physical Activity

Engaging in regular exercise contributes to cardiovascular health and helps maintain optimal blood pressure levels. Cardiovascular activities, such as walking, jogging, or swimming, can support overall kidney function. However, intense and prolonged exercise without adequate hydration should be avoided to prevent dehydration-related stress on the kidneys.

Control Blood Pressure

Hypertension is a significant risk factor for kidney disease and reduced GFR. Monitoring and controlling blood pressure within the recommended range can help preserve kidney function. Lifestyle modifications, including a low-sodium diet, regular exercise, and stress management, are effective in managing blood pressure.

Manage Blood Sugar Levels

It’s critical for diabetics to keep their blood sugar levels steady. Diabetic nephropathy, a disorder that can eventually deteriorate kidney function, is a result of uncontrolled diabetes. To manage diabetes and maintain kidney health, lifestyle changes, medication adherence, and regular blood sugar testing are crucial.

Avoid Nephrotoxic Substances

Certain medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), some antibiotics, and excessive use of certain other over-the-counter medications, can have nephrotoxic effects. It’s crucial to use medications as directed by healthcare professionals and avoid unnecessary exposure to substances that may harm kidney function.

Quit Smoking

Smoking has been linked to a higher risk of kidney disease and can contribute to the progression of existing renal conditions. Quitting smoking is a positive step toward improving overall kidney health and preserving GFR.

Limit Alcohol Intake

Excessive alcohol consumption can contribute to high blood pressure and liver disease, both of which can impact kidney function. Moderating alcohol intake supports overall health and kidney function.

Maintain a Healthy Weight

Being overweight is associated with an increased risk of kidney disease. Adopting a healthy lifestyle that includes a balanced diet and regular physical activity can help achieve and maintain a healthy weight, reducing the risk of kidney-related complications.

Regular Health Check-ups

Regular monitoring of kidney function through routine health check-ups, including blood tests to assess GFR and other kidney markers, allows for early detection of potential issues. Timely intervention can help manage and slow the progression of kidney disease.

Adopting a holistic approach to health that includes hydration, a balanced diet, regular exercise, and healthy lifestyle choices is instrumental in supporting and potentially improving your Glomerular Filtration Rate. Individualized recommendations should be discussed with healthcare professionals based on personal health conditions and needs.

LifeDNA’s Glomerular Filtration Rate Report

Unlock the secrets to your kidney health with LifeDNA’s Glomerular Filtration Rate (GFR) Report. Our comprehensive analysis provides valuable insights into your kidney function, helping you understand and optimize your overall well-being. 

Discover personalized recommendations to support a healthy GFR, backed up by cutting-edge genetic insights. But that’s not all – elevate your wellness journey with LifeDNA’s complete Vitamins & Supplements Report. Dive deep into the intricacies of your nutritional needs and explore tailored recommendations for a healthier, more vibrant you. 

Don’t miss out on our informative reads like the genetics of Vitamin K and Vitamin A for additional wellness wisdom. Take control of your wellness today and embark on a journey to a healthier, more informed lifestyle. Start with LifeDNA today. 

Summary

  • The glomerulus, a network of microscopic blood arteries located in the renal corpuscle, is responsible for filtering blood to create urine.
  • An essential function of the kidneys in humans is glomerular filtration, which is vital to the body’s capacity to control fluid balance and get rid of waste.  
  • The amount of fluid filtered by the glomerulus in a specific amount of time is measured by the glomerular filtration rate or GFR. 
  • Glomerular filtration traps larger molecules and cells while permitting just certain elements—water, electrolytes, and small molecules—to pass through, preserving the body’s delicate equilibrium.
  • Genetic indicators linked to glomerular filtration rates (GFR) offer important insights into the variation in kidney function and the vulnerability of the kidneys to various illnesses. External factors can potentially impact the complex interaction of physiological systems that govern renal function.
  • A holistic approach to health, incorporating blood pressure management, a balanced diet, lifestyle choices, and appropriate hydration, is necessary to maintain healthy GFR.

References

  1. https://www.khanacademy.org/test-prep/mcat/organ-systems/the-renal-system/a/renal-physiology-glomerular-filtration#:~:text=What%20is%20glomerular%20filtration%3F,be%20eliminated%20from%20your%20body.
  2. https://www.ucsfhealth.org/medical-tests/glomerular-filtration-rate#:~:text=Definition,through%20the%20glomeruli%20each%20minute.
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317173/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002812/#:~:text=Decline%20in%20kidney%20function%20measured,steeper%20after%20development%20of%20albuminuria.
  5. https://pubmed.ncbi.nlm.nih.gov/34828293/
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535213/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533959/
  8. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185476
  9. https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-020-1686-2#:~:text=In%20this%20population%2Dbased%20study,were%20associated%20with%20lower%20GFR.
  10. https://www.ncbi.nlm.nih.gov/books/NBK553144/
  11. https://www.sciencedirect.com/topics/earth-and-planetary-sciences/ultrafiltration
  12. https://www.healthline.com/health/kidney-disease/can-gfr-be-improved#about-gfr
  13. https://www.upmc.com/services/transplant/kidney-pancreas/glomerular-filtration-rate-calculator

Customer Reviews

Christopher Devlin
Christopher Devlin
LifeDNA Customer
Read More
I am so impressed with this service. I have even discussed these recommendations with my health care providers and they are all impressed too! I can’t compare it with other services as I have only tried this but I recommend. Also I think I pulled my genetics in from ancestry too which was super convenient.
Lei'a
Lei'a
LifeDNA Customer
Read More
Great source of information I was looking for a platform to make use of my existing raw data from Ancestry. I’m glad I found LifeDNA. I originally took a DNA test to learn about my roots and it’s great to know that my DNA could also play a big role in my health, diet, and even my skin. Overall, all the reports are incredible.
Shiraz Dole
Shiraz Dole
LifeDNA Customer
Read More
It is crazy how I felt that I had a strong understanding of my bodies needs, but after having my DNA analyzed by the LifeDNA team, I realized that there was so much I still did not know.
Doc Sheila Lim
Doc Sheila Lim
LifeDNA Customer
Read More
I got some pretty useful insight that helped me with my diet.
Previous
Next

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Personalized Nutrition: How Your Genes Affect Vitamin K Levels

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Personalized Nutrition: How Your Genes Affect Vitamin K Levels

Date of Content: November 7, 2023
Written by: Jess Gayo
Reviewed by: Maarit Tiirikainen, PhD

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Overview

What is Vitamin K?

Ever heard your parents tell you to eat your fruits and veggies for more Vitamin K? If not, you’re not the only one. Vitamin K is not as popular among the necessary vitamins to get but it is no less important than Vitamins A, B, and C when it comes to keeping the body healthy. 

Vitamin K is a fat-soluble vitamin that plays a crucial role in blood clotting, bone metabolism, and cardiovascular health. It exists in two primary forms: K1 (phylloquinone) and K2 (menaquinone). Phylloquinone is found in green leafy vegetables, while bacteria synthesize menaquinone in the human gut, and is also present in fermented foods.

The main function of vitamin K is to activate proteins involved in blood clotting, such as prothrombin. Without sufficient vitamin K, the blood clotting process would be impaired, leading to increased bleeding tendencies. Vitamin K also contributes to bone health by regulating calcium within the bones and arteries. It helps to prevent the calcification of arteries and soft tissues, reducing the risk of cardiovascular diseases.

Vitamin K deficiency is relatively rare, but it can occur in individuals with malabsorption issues, certain medical conditions, or those taking medications that interfere with vitamin K metabolism. Symptoms of deficiency include easy bruising, bleeding, and impaired bone health. In some cases, supplements may be recommended, particularly for individuals with specific health conditions or those taking medications that interfere with vitamin K absorption.

Vitamin K Levels

Where Can You Find Vitamin K?

There are many sources of Vitamin K. Vitamin K1, also known as phylloquinone, is abundant in green leafy vegetables such as kale, spinach, broccoli, and lettuce. These vegetables are potent sources that contribute significantly to daily vitamin K intake.

Vitamin K2, or menaquinone, is found in fermented foods like kefir and natto (fermented soybeans), cheeses, and certain other animal products. The human gut microbiota also synthesizes a portion of vitamin K2, enhancing overall availability. 

To maintain optimal vitamin K levels, incorporating a diverse range of foods into the diet is crucial. As with any nutrient, balance is key, and consulting with a healthcare professional can help tailor dietary choices to individual needs, ensuring adequate vitamin K intake for blood clotting, bone health, and overall well-being.

What Can Affect Vitamin K Levels?

Diet, problems with absorption, interactions between medications, and gastrointestinal health can all affect vitamin K levels. Optimal vitamin K levels are supported by a diet high in fermented foods, green leafy vegetables, and sufficient gut flora. Functional Vitamin K deficits may result from some medicines that interfere with its activity, such as blood thinners. 

Vitamin K absorption may be impacted by conditions that influence fat absorption, such as inflammatory bowel disorders or celiac disease. Maintaining healthy bones, appropriate blood coagulation, and general vitamin K-dependent bodily processes all depend on these variables. 

Genetic Factors

The way a person gets this vital nutrient is influenced by genetic factors associated with vitamin K metabolism. Although this area of study is still developing, some genetic variants have been shown to affect the way the body metabolizes and uses vitamin K.

A more complete picture of the effects of individual genetic variants on vitamin K metabolism is likely to emerge as genetic research progresses. With the ability to customize interventions based on each person’s distinct genetic composition, this knowledge could advance precision medicine and lead to better health outcomes.

VKORC1 Gene

Vitamin K is crucial for bone health, and its processing depends on a gene called VKORC1. One study shows that those with a specific VKORC1 variation (9041 GG and GA) were more likely to have low bone density, suggesting a higher risk for them. The study indicates that a genetic difference in the VKORC1 gene may be associated with low bone density, possibly influencing osteoporosis.

GGCX Gene

Another significant genetic component is the GGCX gene, which encodes an enzyme that activates vitamin K-dependent proteins. Changes in GGCX, such as those associated with the SNP rs10187424, may have an impact on how well this activation mechanism works, which may have an impact on bone metabolism and blood coagulation.

CYP4F2 Gene

The CYP4F2 gene has been associated with vitamin K metabolism. This gene codes for an enzyme involved in the breakdown of vitamin K. Polymorphisms in CYP4F2 may influence how quickly the body clears vitamin K, impacting its availability for various biological functions.

Understanding one’s genetic predisposition can have implications for personalized nutrition and healthcare. Individuals with certain genetic variations may benefit from tailored dietary approaches, supplementation, or adjusted medication regimens to optimize their vitamin K status.

Environmental Factors

Genetic factors represent just one aspect of the complex interplay influencing active vitamin K levels. Environmental factors, overall health, and lifestyle choices also play significant roles.

Diet

Variety of Foods: A diverse diet rich in green leafy vegetables, such as kale, spinach, and broccoli, provides ample vitamin K1. Cheese, meat, and fermented foods like natto or sauerkraut contribute to vitamin K2. A balanced and varied diet helps ensure sufficient vitamin K intake.

Gut Health

Microbiota: The gut microbiota plays a crucial role in synthesizing vitamin K2. Individuals with imbalances in gut bacteria or those taking antibiotics that disrupt the microbiota may experience altered vitamin K metabolism.

Medications

Antibiotics: Certain antibiotics can affect the gut microbiota, potentially impacting vitamin K synthesis. Individuals on prolonged or frequent antibiotic courses may need to monitor their vitamin K levels.

Liver Function

Liver Diseases: Since the liver is crucial for synthesizing clotting factors dependent on vitamin K, liver diseases can affect vitamin K metabolism. Individuals with liver disorders may have altered vitamin K levels.

Age and Life Stage

Infants: Newborns may have lower vitamin K levels, as they are born with limited stores and their gut microbiota is still developing. Vitamin K supplementation is often recommended for newborns to prevent bleeding disorders.

Lifestyle Choices

Alcohol Consumption: Excessive alcohol intake can impact liver function, potentially affecting the synthesis of vitamin K-dependent proteins involved in blood clotting.

Weight Loss Surgeries

Bariatric Surgery: Procedures that involve the removal or bypass of parts of the gastrointestinal tract can lead to malabsorption of fat-soluble vitamins, including vitamin K.

Smoking

Tobacco Use: Some studies suggest that smoking may be associated with lower vitamin K levels. The exact mechanisms are not fully understood, but smoking-related oxidative stress could be a contributing factor.

Physical Activity

Exercise: Regular physical activity has been associated with improved vitamin K status. However, extreme exercise or training may increase the risk of vitamin K deficiency due to increased metabolic demands.

Understanding and addressing these environmental factors are crucial for maintaining optimal vitamin K levels. Individuals with specific health conditions, those taking medications, or those undergoing significant lifestyle changes should consult healthcare professionals to assess and manage their vitamin K status effectively. Regular monitoring and adjustments to dietary habits or supplementation may be recommended based on individual needs and circumstances.

Why is Vitamin K Given to Newborn Babies?

Vitamin K is routinely administered to newborn babies shortly after birth to prevent a rare but potentially serious condition known as Vitamin K Deficiency Bleeding (VKDB) or Hemorrhagic Disease of the Newborn (HDN). This practice has become a standard part of newborn care in many countries.

Newborns are born with limited stores of vitamin K, and their ability to produce it through their gut microbiota is not fully developed in the early days of life. Vitamin K is essential for the synthesis of clotting factors in the liver. Without sufficient vitamin K, newborns are at risk of bleeding disorders, which can lead to serious complications, including internal bleeding in the brain.

The most severe form of VKDB, known as early onset VKDB, can occur within the first 24 hours to the first week of life. Since newborns may not have enough vitamin K to prevent bleeding during this critical period, a single intramuscular vitamin K injection is commonly administered shortly after birth. In some cases, oral vitamin K may be given as an alternative.

This preventive measure has proven highly effective in reducing the incidence of VKDB and its associated complications. While VKDB is rare, the potential consequences underscore the importance of this routine administration of vitamin K, ensuring the newborn’s blood-clotting system is adequately supported during the vulnerable early days of life.

What Happens if You Have Vitamin K Deficiency?

Vitamin K deficiency can lead to impaired blood clotting, potentially resulting in excessive bleeding and bruising. Since vitamin K is essential for the synthesis of clotting factors in the liver, a deficiency can compromise the body’s ability to form blood clots effectively. This may manifest as easy bruising, prolonged bleeding from wounds, or, in severe cases, spontaneous bleeding.

Vitamin K is also involved in regulating calcium in the bones and arteries. A deficiency may contribute to abnormal calcium deposition in soft tissues, potentially impacting bone health and cardiovascular function. Individuals experiencing symptoms of vitamin K deficiency should seek medical attention for proper diagnosis and intervention.

What is the Suggested Daily Intake of Vitamin K?

The recommended daily intake of vitamin K can vary based on factors such as age, sex, and life stage. Generally, the Adequate Intake (AI) levels for vitamin K established by health authorities are as follows:

Infants

  • 0 to 6 months: 2 micrograms (mcg) per day
  • 7 to 12 months: 2.5 mcg per day

Children

  • 1 to 3 years: 30 mcg per day
  • 4 to 8 years: 55 mcg per day
  • 9 to 13 years: 60 mcg per day

Adolescents and Adults

  • Males 14 to 18 years: 75 mcg per day
  • Females 14 to 18 years: 75 mcg per day
  • Males 19 years and older: 120 mcg per day
  • Females 19 years and older: 90 mcg per day

Pregnant and Breastfeeding Women

  • Pregnant females 14 to 18 years: 75 mcg per day
  • Pregnant females 19 years and older: 90 mcg per day
  • Breastfeeding females 14 to 18 years: 75 mcg per day
  • Breastfeeding females 19 years and older: 90 mcg per day

These recommendations are based on maintaining adequate blood clotting and bone health. It’s important to note that individual needs may vary, and factors such as medical conditions, medications, and diet can influence vitamin K requirements.

Individuals with specific health concerns should consult healthcare professionals for personalized guidance on meeting their vitamin K needs.

Ways to Maintain Vitamin K Levels

Maintaining adequate vitamin K levels is crucial for overall health, especially for proper blood clotting and bone metabolism. 

Dietary Sources

  • Green Leafy Vegetables: Incorporate kale, spinach, broccoli, Brussels sprouts, and other leafy greens into your diet. These vegetables are rich in vitamin K1, the primary form of vitamin K found in plant foods.
  • Fermented Foods: Include fermented options like kefir, sauerkraut, and natto, as they provide vitamin K2, the form also synthesized by bacteria in the gut.
  • Varied Nutrient Intake: Consume a well-balanced diet that includes a variety of foods to ensure you receive a spectrum of essential nutrients, including vitamin K. A diverse diet supports overall health and helps prevent deficiencies.
  • Fat Absorption: Since vitamin K is fat-soluble, consuming healthy fats can aid in its absorption. Include sources of healthy fats such as olive oil, avocados, and nuts in your meals.

Supplements

  • Probiotics: Support a healthy gut microbiome by including probiotic-rich foods or supplements. A balanced gut microbiota contributes to the synthesis of vitamin K2.
  • Consultation with Healthcare Professionals: In cases where dietary intake may be insufficient or if there are concerns about absorption, healthcare professionals may recommend vitamin K supplements. However, self-prescription is not advisable, as excessive vitamin K supplementation can have adverse effects.
  • Monitor Nutrient Levels: Include vitamin K levels in routine health checkups, especially if you have conditions affecting nutrient absorption or metabolism. Early detection of deficiencies allows for timely intervention.

Awareness of Medications

  • Anticoagulants: If you are taking anticoagulant medications (blood thinners), work closely with your healthcare provider. These medications can interfere with vitamin K’s clotting function, and adjustments may be necessary to maintain a balance between preventing excessive clotting and avoiding bleeding issues.

Lifestyle Choices

  • Avoid Excessive Alcohol: Excessive alcohol intake can impact liver function, potentially affecting the synthesis of vitamin K-dependent clotting factors. Moderation is key.
  • Regular Exercise: Engage in regular physical activity, as it has been associated with improved vitamin K status. However, extreme exercise may increase the risk of deficiency due to higher metabolic demands.

Pregnancy and Infancy

  • Supplementation for Newborns: Newborns are often given vitamin K supplements shortly after birth to prevent Vitamin K Deficiency Bleeding (VKDB).

By incorporating these strategies into your lifestyle, you can maintain optimal vitamin K levels, supporting essential physiological functions and promoting overall health. Always consult with healthcare professionals for personalized advice, especially if you have specific health concerns or conditions.

LifeDNA’s Vitamin K Report

Unlock the secrets of your health with LifeDNA’s Vitamin K Report – your personalized guide to optimizing Vitamin K levels for enhanced well-being! Our comprehensive report delves into your unique genetic makeup, providing insights into how your body processes and utilizes Vitamin K. Discover the factors that may impact your vitamin K levels and receive personalized recommendations to maintain an optimal balance.

LifeDNA’s cutting-edge technology analyzes your DNA to uncover valuable information about your vitamin K metabolism. Armed with this knowledge, you can make informed choices about your diet, lifestyle, and supplementation to support your body’s natural processes.

But that’s not all – explore our complete Vitamins Report for a holistic understanding of how your genetics influence your nutrient needs. And don’t miss out on other insightful reads such as our Glomerular Filtration Report and Vitamin A Report for additional health insights tailored just for you.

Avail of LifeDNA’s Vitamin K Report and unlock the power of personalized health recommendations. Visit our website to learn more and start your personalized wellness transformation. Take charge of your wellness journey today.

Summary

  • Fat-soluble vitamin K is essential for healthy blood coagulation, bone metabolism, and cardiovascular function. 
  • Vitamin K comes in two main forms; K1 (phylloquinone) and K2 (menaquinone).. Green leafy vegetables contain phylloquinone, whereas menaquinone is produced by bacteria in the human stomach and can also be found in some foods.
  • Although it is comparatively uncommon, vitamin K shortage can happen to people who have problems with malabsorption, have specific medical disorders, or are on medications that affect how well their bodies metabolize vitamin K. 
  • Eating a wide variety of food items is essential for maintaining healthy levels of vitamin K in the diet. Balance is important when it comes to nutrition, and speaking with a healthcare provider can help you customize your diet to meet your specific needs.
  • One part of the intricate interactions affecting vitamin K levels is genetic but significant contributions are also played by lifestyle choices, general health, and environmental factors.
  • A lack of vitamin K may affect blood clotting, which may cause excessive bleeding and bruises.
  • For individualized advice, always seek the opinion of medical professionals, particularly if you have any particular health issues or diseases.

References

  1. https://www.hsph.harvard.edu/nutritionsource/vitamin-k/
  2. https://www.mountsinai.org/health-library/supplement/vitamin-k
  3. https://www.msdmanuals.com/home/disorders-of-nutrition/vitamins/vitamin-k-deficiency#:~:text=The%20main%20symptom%20of%20vitamin,stools%20may%20be%20tarry%20black.
  4. https://www.healthline.com/nutrition/foods-high-in-vitamin-k
  5. https://pubmed.ncbi.nlm.nih.gov/18374188/
  6. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/gamma-glutamyl-carboxylase#:~:text=in%20Pharmacogenomics%2C%202013-,GGCX,candidate%20for%20affecting%20warfarin%20pharmacodynamics.
  7. https://www.sciencedirect.com/science/article/pii/S0002916523048475?via%3Dihub
  8. https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-8-S1-S11
  9. https://www.sciencedirect.com/science/article/abs/pii/S0031938423001774#:~:text=The%20diversity%20of%20the%20gut,family%20of%20bacteria%20%5B11%5D.
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385738/
  11. https://www.cdc.gov/ncbddd/vitamink/faqs.html#:~:text=Low%20levels%20of%20vitamin%20K%20can%20lead%20to%20dangerous%20bleeding,asked%20questions%20and%20their%20answers.
  12. https://www.healthdirect.gov.au/vitamin-k-deficiency#:~:text=and%20vitamin%20K.-,What%20are%20the%20symptoms%20of%20vitamin%20K%20deficiency%3F,also%20make%20your%20periods%20heavier.
  13. https://www.healthdirect.gov.au/vitamin-k-deficiency#:~:text=and%20vitamin%20K.-,What%20are%20the%20symptoms%20of%20vitamin%20K%20deficiency%3F,also%20make%20your%20periods%20heavier.
  14. https://ods.od.nih.gov/factsheets/VitaminK-Consumer/
  15. https://www.webmd.com/vitamins-and-supplements/ss/slideshow-ways-to-get-vitamin-k
  16. https://www.ihtc.org/warfarin-and-vitamin-k#:~:text=How%20Does%20Warfarin%20Interact%20with,the%20action%20of%20this%20medication.

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I am so impressed with this service. I have even discussed these recommendations with my health care providers and they are all impressed too! I can’t compare it with other services as I have only tried this but I recommend. Also I think I pulled my genetics in from ancestry too which was super convenient.
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Great source of information I was looking for a platform to make use of my existing raw data from Ancestry. I’m glad I found LifeDNA. I originally took a DNA test to learn about my roots and it’s great to know that my DNA could also play a big role in my health, diet, and even my skin. Overall, all the reports are incredible.
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It is crazy how I felt that I had a strong understanding of my bodies needs, but after having my DNA analyzed by the LifeDNA team, I realized that there was so much I still did not know.
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I got some pretty useful insight that helped me with my diet.
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*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Navigating Vitamin A: Your Genetic Blueprint for Vision and Wellness

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Navigating Vitamin A: Your Genetic Blueprint for Vision and Wellness

Date of Content: November 11, 2023
Written by: Harvey Talento
Reviewed by: Maarit Tiirikainen, PhD

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What Is Vitamin A?

Vitamin A, including its source beta-carotene, is a crucial nutrient in the human body, playing a key role in functions like vision, cell development, and immune support. It can be acquired through animal products like meat and dairy (as preformed vitamin A, or retinol) or from colorful fruits and vegetables ( as provitamin A, or carotenoids). Once consumed, the body converts these into the active forms necessary for essential functions.

Vitamin A Levels

What Does Vitamin A Do?

Vitamin A is a versatile nutrient in the body, supporting crucial functions such as vision, cellular regulation, and potentially, even cancer prevention. Additionally, its antioxidant properties help protect cells from damage, emphasizing its importance in maintaining overall health.

Vision

Vitamin A, in the form of retinol, plays a pivotal role in our ability to see. It is a critical component of the visual cycle and is converted into retinal, which is essential for vision. Without sufficient Vitamin A, vision can be impaired.

Cellular Health

Retinoic acid, a metabolite of Vitamin A, serves as a gene regulator with significant importance. It plays a crucial role in regulating genes responsible for various cellular processes, including cell morphogenesis, differentiation, and proliferation. This function is integral for the proper development and maintenance of our body’s tissues.

Antioxidant Activity

Provitamin A, such as beta-carotene, found in colorful fruits and vegetables, functions as an antioxidant. In addition to beta-carotene, other dietary carotenoids contribute to this antioxidant effect. Their role is to reduce harmful free radicals in the body, which can cause DNA damage and potentially lead to cancer. Vitamin A, through its antioxidant properties, helps protect our cells from oxidative stress and its associated damage.

Read more about Antioxidant Status here.

Genetics of Vitamin A Levels

The genetics of Vitamin A and beta-carotene levels in blood can be discussed by looking at specific genes. The following are some of the key genes that play a significant role.

RBP4 Gene

In an initial GWAS, 10 SNPs on chromosome 10 showed significant associations with circulating retinol concentration. Notably, two highly significant SNPs near the RBP4 gene, which encodes retinol-binding protein 4 (RBP4), were identified, with rs10882272 being the most prominent. In pooled and replication analyses, rs10882272 consistently demonstrated its significance in determining retinol levels.

TTR Gene

On chromosome 18, eight SNPs clustered near the TTR gene, which codes for transthyretin (TTR), were found to be significantly associated with serum retinol levels in an initial GWAS. Among these SNPs, rs1667255 exhibited the strongest signal. While it didn’t reach statistical significance in the replication dataset, a combined meta-analysis confirmed its substantial impact on serum retinol levels.

BCO1 Gene

Homo sapiens beta-carotene oxygenase 1 (BCO1) encodes a crucial enzyme involved in the conversion of beta-carotene to vitamin A. Its function includes catalyzing the oxidative cleavage of beta-carotene into two retinal molecules. Mutations in the BCO1 gene are associated with autosomal dominant hypercarotenemia and vitamin A deficiency.

BCMO1 Gene

A set of SNPs, including rs11645428 and rs6564851, are found near the β-carotene 15,15′-monooxygenase 1 (BCMO1) gene on chromosome 16. This gene is crucial for the initial steps of converting dietary provitamin carotenoids into vitamin A in the small intestine.

Non-genetic Factors Influencing Vitamin A Levels

Beyond genetic factors, several non-genetic elements play a significant role in determining an individual’s Vitamin A levels. These factors can influence the absorption, utilization, and overall status of Vitamin A within the body.

  • Dietary Intake: Consuming foods rich in beta-carotene, such as colorful fruits and vegetables, is crucial for optimal Vitamin A levels.
  • Fat Absorption: Adequate dietary fat intake enhances Vitamin A absorption and utilization.
  • Alcohol Consumption: Excessive alcohol use can deplete Vitamin A stores in the liver, potentially causing deficiency.
  • Infections and Diseases: Certain medical conditions and infections may hinder Vitamin A absorption and storage.
  • Dietary Choices: Vegetarians and those with dietary restrictions should incorporate beta-carotene sources for sufficient intake.
  • Supplementation: Use Vitamin A supplements under medical supervision to prevent potential toxicity.

Understanding these non-genetic factors, including the role of beta-carotene, is vital for maintaining optimal Vitamin A levels and overall health.

How to Improve Your Vitamin A Levels Naturally

Vitamin A deficiency is a global concern, particularly in developing regions where access to nutritious foods is limited. This deficiency can lead to a range of health issues, including night blindness, corneal damage, and even irreversible blindness, making it a critical problem to address. To combat Vitamin A deficiency and its associated health risks, it’s vital to explore strategies for improving Vitamin A levels through dietary and lifestyle choices.

Prioritize Foods Rich in Vitamin A and Maintain a Balanced Diet

Elevate your Vitamin A and beta-carotene levels by incorporating foods like liver, fish, dairy products, eggs, and various colorful fruits and vegetables into your daily diet.

Enhance Provitamin A Sources and Utilize Cooking Techniques

Embrace foods rich in provitamin A carotenoids, particularly beta-carotene, in leafy green vegetables, orange and yellow vegetables, fruits, and tomato products. Utilize cooking methods that boost the bioavailability of beta-carotene from these foods, ensuring a natural increase in Vitamin A levels.

Moderate Alcohol Consumption and Seek Professional Guidance for Supplementation

Excessive alcohol intake can deplete your beta-carotene and Vitamin A reserves. Maintain optimal Vitamin A levels by limiting alcohol consumption.

Regularly Monitor Your Vitamin A Status

In cases of severe deficiency in Vitamin A and beta-carotene levels or dietary restrictions, consult with a healthcare professional for supplementation. This ensures you achieve the right balance and avoid potential toxicity.

About the LifeDNA Reports

LifeDNA’s Nutrition and Vitamins & Supplements Reports are your personalized guides to optimizing Vitamin A and Beta-carotene levels based on your unique genetic traits. These reports delve into your genetic predispositions, providing tailored dietary recommendations to enhance both your Vitamin A and Beta-carotene intake.

Discover if your genetics indicate a higher likelihood of Vitamin A deficiency and Beta-carotene conversion, and take the first step towards achieving optimal Vitamin A and Beta-carotene status with the LifeDNA Nutrition and Vitamins & Supplements Reports. Get started today!

Summary

  • Vitamin A is vital for overall health and is found in animal products and colorful fruits and veggies. Vitamin A is essential for vision, cell development, and cancer prevention with its antioxidant properties.
  • Genetic variants impact serum Vitamin A levels.
  • Diet, fat absorption, alcohol, infections, and dietary choices influence Vitamin A levels.
  • A balanced diet, beta-carotene-rich foods, moderate alcohol, and professional guidance help maintain healthy Vitamin A levels.

References

  1. https://pubmed.ncbi.nlm.nih.gov/29493984/
  2. https://pubmed.ncbi.nlm.nih.gov/10637381/
  3. https://lifedna.com/what-is-gwas/
  4. https://academic.oup.com/hmg/article/20/23/4724/557338
  5. https://www.cell.com/ajhg/fulltext/S0002-9297(09)00010-X
  6. https://doi.org/10.1016/j.ajhg.2008.12.019
  7. https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional
  8. https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional
  9. https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional

Customer Reviews

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I am so impressed with this service. I have even discussed these recommendations with my health care providers and they are all impressed too! I can’t compare it with other services as I have only tried this but I recommend. Also I think I pulled my genetics in from ancestry too which was super convenient.
Lei'a
Lei'a
LifeDNA Customer
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Great source of information I was looking for a platform to make use of my existing raw data from Ancestry. I’m glad I found LifeDNA. I originally took a DNA test to learn about my roots and it’s great to know that my DNA could also play a big role in my health, diet, and even my skin. Overall, all the reports are incredible.
Shiraz Dole
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It is crazy how I felt that I had a strong understanding of my bodies needs, but after having my DNA analyzed by the LifeDNA team, I realized that there was so much I still did not know.
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I got some pretty useful insight that helped me with my diet.
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*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Proteinuria: Unraveling the Clues in Your Urine

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Proteinuria: Unraveling the Clues in Your Urine

Date of Content: November 9, 2023
Written by: Harvey Talento
Reviewed by: Maarit Tiirikainen, PhD

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What is Proteinuria?

Proteinuria may seem like a complex term, but it can be simplified as the presence of excessive protein in urine. It can also indicate potential kidney issues or broader health concerns.

Proteins are fundamental building blocks in the body, performing essential functions such as muscle and bone development, regulating blood fluid levels, defending against infections, and aiding in tissue repair. Ideally, these proteins should remain in the bloodstream. When they appear in urine, it could signify a problem, potentially affecting your overall health.

Proteinuria can arise from various factors, ranging from temporary and benign situations like dehydration or intense physical activity to more severe underlying conditions like kidney diseases or immune disorders. Once diagnosed through medical testing, a treatment plan can be tailored to manage proteinuria effectively, ensuring your health remains a top priority.

Understanding proteinuria is a crucial first step in maintaining your well-being.

Proteinuria

What Causes Proteinuria?

Proteinuria stems from a complex interplay of genetic and non-genetic influences. Genetic factors encompass hereditary aspects and variations in specific genes, while non-genetic factors involve environmental elements and various external triggers. These factors collectively contribute to the development of proteinuria and its potential health implications.

Genetic Factors

Genetic factors play a relatively rare but significant role in causing proteinuria, affecting children and adults. To shed light on this complex aspect of proteinuria, researchers have made noteworthy progress by delving into the genetic and molecular underpinnings of specific syndromic and nonsyndromic proteinuric disorders. These disorders stem from mutations in genes responsible for the structural components of the glomerular filtration barrier, which plays a pivotal role in filtering the blood and retaining essential proteins.

LRP2 and CUBN

Genetic diversity has a profound influence on urinary biomarkers and their role in diagnosing kidney, urinary tract, and metabolic diseases. In a comprehensive study involving 150,274 Icelanders and their urine dipstick measurements, 20 association signals emerged, shedding light on how genetic variants impact clinical entities defined by the urine dipstick.

The study unveiled two variants associated with proteinuria, located in LRP2 and CUBN, which encode megalin and cubilin, key co-transporters responsible for the uptake of proteins in the proximal tubules of the kidneys. 

These novel findings emphasize the impact of genetic factors on urinary biomarkers and further underscore the significance of genetic diversity in understanding conditions affecting the kidneys and urinary tract. The study’s results unveil the complex interplay of genetic diversity in influencing urinary biomarkers, offering valuable insights into kidney and urinary tract health.

NR3C2 and COL4A4

In a comprehensive genome-wide association study involving 382,500 participants from the UK Biobank, researchers identified genetic variants associated with albuminuria, a key marker of kidney health. Notably, the study revealed a wealth of genetic insights, uncovering 33 genome-wide significant loci, including 32 novel and one previously reported association at the CUBN locus, further enhancing our understanding of kidney-related conditions.

Among the newly discovered associations, the NR3C2 and COL4A4 loci have potential clinical significance. The NR3C2 gene encodes the mineralocorticoid receptor, and it’s worth noting that mineralocorticoid receptor antagonists like spironolactone and eplerenone have been shown to reduce albuminuria when added to other antihypertensive medications. This finding highlights the potential for targeted therapies in managing albuminuria.

Moreover, mutations in the COL4A4 gene and its neighboring counterpart, COL4A3, can lead to autosomal Alport syndrome, a condition characterized by kidney disease, which may include proteinuria. These genetic revelations provide valuable insights into the intricate genetic factors influencing kidney health, paving the way for more tailored diagnostic and therapeutic approaches.

Non-Genetic (Environmental) Factors

In addition to genetic factors, non-genetic or environmental factors contribute significantly to proteinuria. Various conditions, such as infections, lifestyle choices, and environmental exposures, can trigger proteinuria as a response to external influences. Investigating these non-genetic factors helps us understand how external elements contribute to proteinuria and the measures that can be taken to prevent or effectively manage it.

Benign Causes of Proteinuria

Among the diverse factors influencing proteinuria, there are benign causes that do not pose a significant threat to overall health and are usually reversible once the underlying issues are resolved. Such factors include acute illnesses, physical exertion, and other benign triggers. The following are some common benign causes of proteinuria:

  • Fever
  • Acute illness
  • Exercise/intense physical activity
  • Orthostatic proteinuria
  • Dehydration
  • Emotional stress
  • Heart injury
  • Inflammatory process

Transient Proteinuria

Transient proteinuria is a temporary condition characterized by elevated protein levels in the urine. This proteinuria typically occurs due to benign and reversible factors such as:

  • Urinary tract infection
  • Orthostatic proteinuria (occurs after a patient has been upright for an extended period. It is typically absent in early morning urine and is more common in individuals under 30 years of age)
  • Fever
  • Heavy exercise
  • Vaginal mucus
  • Pregnancy

Persistent Proteinuria

Persistent proteinuria, on the other hand, is a condition where elevated protein levels in the urine persist over time and may signify underlying renal or systemic health issues. Here are factors that contribute to the development of persistent proteinuria:

  • Primary Renal Disease (including glomerular conditions such as glomerulonephritis, as well as tubular disorders)
  • Secondary Renal Disease (including diabetes mellitus, connective tissue diseases, vasculitis, amyloidosis, and myeloma)
  • Heart Conditions
  • Hypertension

Is Proteinuria Serious?

Proteinuria is a common finding in urinalysis and can serve as an indicator of various medical conditions, with implications that range from benign to more serious. Some cases of proteinuria, such as orthostatic proteinuria, are relatively benign and may be associated with a favorable prognosis. However, other instances of proteinuria can be indicative of more serious underlying health issues, such as glomerular disease or multiple myeloma.

The seriousness of proteinuria often depends on its root causes and the amount of protein excreted in the urine. Several factors can contribute to increased protein levels in the urine, including changes in glomerular filtration, pathological alterations of the glomeruli, and toxic damage that increases urinary excretion of all proteins.

Since proteinuria may indicate severe renal conditions, further evaluation is crucial for diagnosis and proper medical management. It is a significant marker for potential underlying health issues needing attention and diagnosis.

What are the Symptoms of Proteinuria?

Proteinuria can manifest through various symptoms. It’s important to note that in the early stages, proteinuria may not cause visible symptoms, making regular check-ups and urinalysis crucial for early detection. However, when symptoms do occur, they can include:

  • Foamy Urine

One common symptom of proteinuria is the production of foamy or frothy urine. This occurs because the excess protein in the urine can become bubbly when it flows into the toilet bowl.

  • Swelling of the Hands, Feet, Face, and/or Abdomen

Another noticeable symptom can be swelling, also known as edema. Excess protein leaking into the urine means there is less protein in the blood to keep fluid in the blood vessels. As a result, fluid can accumulate in tissues, leading to swelling, particularly in the hands, feet, face, and abdomen.

It’s essential to be aware of these symptoms, particularly if they persist or worsen over time. Detecting and addressing proteinuria in its early stages can help prevent or manage underlying health conditions and minimize potential complications. Regular medical check-ups and urinalysis are key components of proactive healthcare, allowing for the timely evaluation of proteinuria and its associated symptoms.

Management and Considerations for Proteinuria

Proteinuria requires a comprehensive approach to its management. Treatment strategies aim at addressing the underlying cause while minimizing proteinuria levels, particularly albuminuria. Various treatment modalities have been established to manage proteinuria effectively. These treatments encompass:

Drugs Targeting the Renin-Angiotensin-Aldosterone System

In adults with over 300 mg/24 hours of persistent proteinuria, the 2013 Kidney Disease Improving Global Outcomes (KDIGO) guideline strongly recommends using ACE inhibitors or angiotensin receptor antagonists (ARB). These medications, such as ACE inhibitors, have demonstrated their efficacy in reducing proteinuria in diabetic and nondiabetic patients. Beyond their impact on proteinuria, these drugs also lower the risk of renal disease progression, reducing the need for renal replacement therapy. Achieving a 50% reduction in albuminuria within the first six months to a year has been linked to a similar decrease in the risk of renal disease progression.

Diuretics and Aldosterone Antagonists

Moderate to severe proteinuria often results in fluid overload, requiring diuretic therapy and dietary salt restriction. Aldosterone antagonists have shown benefits in proteinuria management, but close monitoring for side effects, including hyperkalemia, is crucial. Combination therapy of ACE inhibitors with aldosterone antagonists may be considered, bearing in mind potential risks and benefits, particularly for patients with heart failure.

Calcium Channel Blockers

Non-dihydropyridine calcium channel blockers (NDCCBs), such as diltiazem and verapamil, have been found to reduce proteinuria more effectively than dihydropyridine calcium channel blockers (DCCBs). Novel NDCCBs, including efonidipine and benedipine, combined with ARBs, have shown promise in reducing proteinuria.

While these treatment options are instrumental in managing proteinuria, therapeutic decisions should be tailored to individual patients, considering their specific conditions and responses to treatment. Additionally, the assessment of combination therapies and potential side effects must be conducted on a case-by-case basis to ensure the most suitable approach.

Differential Diagnosis, Prognosis, Complications, and Consultations

The presence of proteinuria requires a thorough evaluation, considering conditions such as diabetic nephropathy, orthostatic proteinuria, and infections.

Prognosis in proteinuria patients hinges on early recognition and management, offering insights into potential outcomes for conditions such as IgA nephropathy and chronic kidney disease.

Proteinuria elevates the risk of complications such as heart disease, kidney disease progression, and the need for renal replacement therapy, with severity tied to its degree and duration.

Collaboration with specialists, regular monitoring, and holistic management are vital in addressing proteinuria and associated complications, especially in patients with hypertension and diabetes.

About the LifeDNA Vitamins & Supplements Report

LifeDNA’s Vitamins & Supplements Report is your customized roadmap to discovering the potential for proteinuria and can also help you manage the condition based on your genetic characteristics. This report explores your multiple genetic tendencies, offering personalized suggestions so you can optimize your overall wellness.

Find out if your genetics suggest a higher risk of proteinuria and begin your journey towards better wellness management with the LifeDNA Vitamins & Supplements Report. Get started today!

Summary

  • Proteinuria is the presence of excessive protein in urine, which can indicate underlying kidney issues and broader health concerns. It can result from various factors, from temporary and benign situations to severe underlying conditions, highlighting the need for timely diagnosis and management.
  • Genetic factors can contribute to urine composition disorders, with mutations in specific genes affecting the glomerular filtration barrier. Gene variations like those in LRP2, CUBN, NR3C2, and COL4A3 are linked to proteinuria, offering hereditary insights into kidney and urinary tract health.
  • Non-genetic factors, including environmental elements and external triggers, play a significant role in inducing proteinuria. Infections, lifestyle choices, and environmental exposures can trigger proteinuria, with benign and reversible causes such as acute illnesses and dehydration, as well as more persistent factors like renal diseases.
  • The seriousness of proteinuria depends on its root causes and the amount of protein in the urine. While some cases, like orthostatic proteinuria, are relatively benign, others can indicate more serious underlying health issues. Further evaluation is recommended to assess the seriousness of the condition and guide appropriate medical management.
  • Symptoms of proteinuria may include foamy urine and swelling of the hands, feet, face, and abdomen. Early stages may not exhibit visible symptoms, highlighting the importance of regular check-ups and urinalysis for early detection.
  • Managing proteinuria involves addressing the underlying cause and reducing proteinuria levels. Treatment modalities include drugs targeting the renin-angiotensin-aldosterone system, diuretics, and calcium channel blockers, with individualized approaches tailored to specific patients. Collaboration with specialists and regular assessments are essential for holistic management.

References

  1. https://pubmed.ncbi.nlm.nih.gov/33232060
  2. https://www.akdh.org/article/S1548-5595(11)00070-X/fulltext
  3. https://academic.oup.com/hmg/article/28/7/1199/5204138
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174360
  5. https://www.ncbi.nlm.nih.gov/books/NBK564390/
  6. https://pubmed.ncbi.nlm.nih.gov/11011862/
  7. https://pubmed.ncbi.nlm.nih.gov/12631062/
  8. https://www.hopkinsmedicine.org/health/conditions-and-diseases/proteinuria#
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450775/
  10. https://www.ncbi.nlm.nih.gov/books/NBK564390/#
  11. https://pubmed.ncbi.nlm.nih.gov/2544103/
  12. https://www.ncbi.nlm.nih.gov/books/NBK564390/#:~:text=Go%20to%3A-,Differential%20Diagnosis,-The%20presence%20of
  13. https://www.ncbi.nlm.nih.gov/books/NBK564390/#:~:text=Go%20to%3A-,Prognosis,-Studies%20have%20suggested
  14. https://www.ncbi.nlm.nih.gov/books/NBK564390/#:~:text=Go%20to%3A-,Complications,-Proteinuria%20is%20associated
  15. https://www.ncbi.nlm.nih.gov/books/NBK564390/#:~:text=Go%20to%3A-,Consultations,-In%20addition%20to

Customer Reviews

Christopher Devlin
Christopher Devlin
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I am so impressed with this service. I have even discussed these recommendations with my health care providers and they are all impressed too! I can’t compare it with other services as I have only tried this but I recommend. Also I think I pulled my genetics in from ancestry too which was super convenient.
Lei'a
Lei'a
LifeDNA Customer
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Great source of information I was looking for a platform to make use of my existing raw data from Ancestry. I’m glad I found LifeDNA. I originally took a DNA test to learn about my roots and it’s great to know that my DNA could also play a big role in my health, diet, and even my skin. Overall, all the reports are incredible.
Shiraz Dole
Shiraz Dole
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It is crazy how I felt that I had a strong understanding of my bodies needs, but after having my DNA analyzed by the LifeDNA team, I realized that there was so much I still did not know.
Doc Sheila Lim
Doc Sheila Lim
LifeDNA Customer
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I got some pretty useful insight that helped me with my diet.
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*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Visual Acuity: Seeing Clearly Through Science and Genetics

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Visual Acuity: Seeing Clearly Through Science and Genetics

Date of Content: October 10, 2023
Written by: Harvey Talento
Reviewed by: Maarit Tiirikainen, PhD

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What is Visual Acuity?

Visual acuity measures how well a person’s eyes can discern fine details, often referred to as having “20/20” vision. It is akin to the ability to read small text, recognize distant faces, or perceive intricate patterns. Visual acuity is assessed through various tests, commonly involving reading letters or symbols on a chart.

It is influenced by inherent eye factors like light entry and optical quality, as well as external factors such as lighting, corrective lenses, and object contrast. It also acts as an objective indicator of an individual’s capacity to perceive small details in their visual surroundings.

Factors influencing visual acuity encompass the eye’s optical properties and the interplay of external elements that collectively impact the clarity with which these details can be seen.

Visual Acuity

Measuring Visual Acuity

Measuring visual acuity (VA) is a crucial process in evaluating an individual’s ability to perceive fine details in their visual field. It helps establish a baseline recording of VA, aids in diagnosing eye diseases or refractive errors, assesses any vision changes, and even measures the outcomes of surgeries like cataract removal. The procedure involves assessing one eye at a time to ensure accuracy.

To carry out VA testing, you’ll need specific equipment, including a multi-letter Snellen or E chart, a plain occluder (like a card or tissue), a pinhole occluder, a torch or flashlight, and the patient’s documentation. It’s essential to have good natural light or illumination on the chart, providing the patient with the best chance to see and read the chart. The patient is positioned at a distance of 6 meters from the chart, and one eye is tested at a time, first without any spectacles if worn.

Record the smallest readable line, e.g., 6/18, with the upper number indicating chart distance (6 meters) and the lower number representing a ‘normal’ eye’s distance. Incomplete lines can be added to the last complete one. After testing without correction, assess VA with current distance spectacles, recording results for each eye separately.

Use a pinhole occluder if the best vision (6/6) isn’t achieved to identify possible causes of visual impairment, such as corneal irregularities, lens issues, or refractive errors that may require correction.

The same procedure is then repeated for the other eye, and the summary of VA for both eyes is recorded in the patient’s notes. It’s important to ensure that VA testing is done accurately, particularly when dealing with children, as incorrect results can lead to inappropriate decisions and management.

Genetics of Visual Acuity

The genetics of visual acuity is an intricate area of study. In the pursuit of understanding the genetic underpinnings of visual acuity, a Genome-Wide Association Study (GWAS) was conducted. This study, involving a large cohort of individuals, revealed significant genetic associations with visual acuity.

NPLOC4 Locus

Twelve Single Nucleotide Polymorphisms (SNPs) located at the NPLOC4 locus on chromosome 17 reached genome-wide significance. The strongest association was found for rs11656126, with each copy of the major allele shifting an individual towards better visual acuity. This discovery suggests that genetic variations at the NPLOC4 locus play a significant role in regulating visual acuity.

Other Loci

In a targeted replication analysis of SNPs derived from previous literature, two genomic loci reached Bonferroni-corrected significance. The first locus included SNPs from the NPLOC4 and the PDE6G gene and was associated with both reduced refractive error and visual acuity. The second locus spanned an intergenic region upstream of PRSS56, previously associated with myopia and refractive error.

Genes associated with Primary Open-Angle Glaucoma (POAG)

Several Single Nucleotide Polymorphisms (SNPs) have been associated with Primary Open-Angle Glaucoma (POAG), a condition affecting vision. Here are some notable SNPs linked to POAG:

APOE gene (rs449647)

A study involving five different research efforts found a significant association between this SNP and POAG. Apolipoprotein E (APOE) is a member of the lipoprotein class responsible for regulating lipid metabolism in the body. Numerous studies have indicated an association between apolipoprotein E and neurodegenerative diseases, including Alzheimer’s disease and glaucoma.

PLXDC2 gene (rs7081455)

This SNP was reported in three studies, and a significant association was found in the allelic model. Plexin domain-containing 2 (PLXDC2) is a transmembrane protein on the cell surface that acts as a receptor for pigment epithelium–derived factor (PEDF). The presence of a genetic variant in PLXDC2 might result in elevated intraocular pressure.

TMCO1 gene (rs4656461)

This SNP has been studied in four different investigations and was found to have a significant association with POAG in the allelic model. The TMCO1 gene produces a transmembrane protein that is capable of localizing to various cell components such as the Golgi apparatus, endoplasmic reticulum, or mitochondria in different cell types. It is suggested to play a role in apoptosis, the process of programmed cell death.

These SNPs provide valuable insights into the genetic aspects of visual acuity and the risk of developing POAG. Understanding the genetic underpinnings of eye diseases like POAG is crucial in identifying at-risk individuals and developing targeted treatments to preserve and enhance visual acuity.

Non-genetic (Environmental) Factors Affecting Visual Acuity

How well a person can see is influenced by various factors beyond their genes. While genetics play a significant role in shaping our visual potential, several non-genetic factors also come into play, impacting the clarity and sharpness of our vision. Knowing what these non-genetic factors are, is essential to appreciate the full spectrum of influences on visual acuity.

Refractive Error

One significant factor is refractive error. It’s when a person’s eyes don’t focus properly. Myopia, or short-sightedness, means the image focuses in front of the retina, while hyperopia, or long-sightedness, means the image focuses behind the retina. Both of these conditions can result in blurriness.

Pupil Size

The size of the eye’s pupil is important, too. The pupil controls how much light enters the eye. Larger pupils allow more light in, which can be great for brightness but might introduce problems with clear vision. Smaller pupils reduce these issues but can limit the amount of light reaching the retina. So, a medium-sized pupil strikes a balance for good vision.

Illumination

The level of brightness in the environment also plays a role. Think of it like adjusting the brightness on a TV. In very bright conditions, our eyes can see details well. In lower light, only specific parts of our eyes are active, leading to less sharp vision. It’s about finding the right balance.

Time of Exposure of the Target

When individuals try to see something, the time they spend looking at it matters. It’s not just about the amount of light. For example, when looking at a small, bright dot, it’s more about the light itself. But when looking at a line, the longer it’s observed, the clearer it becomes. It’s a bit complex to explain.

Area of the Retina Stimulated

The center of vision, where individuals look directly, is very sharp. But as they look away from the center, things get blurrier. It’s like having a “sweet spot” in their vision. If they move too far from it, things aren’t as clear.

State of Adaptation of the Eye

Our eyes adapt to different light levels. In bright light, our vision is at its best. In the dark, not so much. Special cells help with this adaptation affecting our ability to see clearly.

Eye Movement

Even when individuals think their eyes are still, they’re making tiny movements. This affects how they see things, making them seem a bit fuzzy.

All these factors combine to determine how well people see. It’s a mix of various elements, with genetics playing a part, but these non-genetic factors are just as crucial. Understanding them can help us take care of our vision and see the world with more clarity.

Correcting Visual Acuity Problems

Visual acuity is a vital aspect of human vision, enabling individuals to achieve 20/20 clarity, and allowing them to discern fine details and navigate the world with precision.

It is pivotal in their ability to read small text, recognize distant faces, and appreciate intricate patterns. However, in the pursuit of perfecting the 20/20 vision, challenges arise, and various correction methods have been explored.

To enhance visual acuity, especially in cases of reduced clarity, several correction methods have been investigated. These methods aim to ultimately improve the overall visual experience.

Vision Correction Lenses

Vision correction methods encompass a range of options, including single-vision lenses, bifocals, progressive addition lenses (PALs), and contact lenses.

Single-vision lenses are commonly prescribed for vision issues, but their effectiveness varies based on individual needs. Bifocals and progressive addition lenses have shown promise in enhancing visual acuity, although further research is ongoing.

Contact lenses, particularly rigid gas permeable (RGP) lenses, can provide clear vision, but the potential reversibility of their effects requires further optimization through research.

Under-Correction of Visual Acuity

Some clinicians recommend under-correction as a strategy to achieve better clarity. Research suggests that under-corrected lenses may not be as effective in enhancing visual acuity as fully corrected ones. The choice between these approaches requires careful consideration and further investigation.

Pharmaceutical Agents

Atropine and pirenzepine, pharmaceutical agents, have demonstrated potential in enhancing visual acuity. Recent studies suggest their ability to significantly improve clarity when combined with specific optical interventions. However, the long-term impact and potential side effects require further investigation.

LASIK (Laser-Assisted In Situ Keratomileusis)

This surgery is a highly advanced and widely practiced medical procedure designed to enhance visual acuity by reshaping the cornea. The cornea, a clear, domed structure on the front surface of the eye, plays a crucial role in focusing light onto the retina, which then transmits visual information to the brain. The shape of the cornea directly affects how light is refracted and where it converges on the retina.

LASIK surgery is primarily employed to correct common refractive errors, including myopia (nearsightedness), hyperopia (farsightedness), and astigmatism. By reshaping the cornea’s curvature, LASIK aims to enable the eye to focus light precisely on the retina, resulting in improved visual clarity.

How to Maintain Good Visual Acuity

Ensuring that your vision remains sharp and your eyes stay healthy is essential for a high-quality life. Here are some practical guidelines to preserve visual acuity and keep your eyes in optimal condition:

Manage Blood Sugar Levels

If you have diabetes, maintaining healthy blood sugar levels is paramount to preventing diabetes-related blindness. Consult your healthcare team to set and achieve goals for managing blood sugar, blood pressure, and cholesterol levels, often called the ABCs of diabetes.

Maintain a Healthy Weight

Staying at a healthy weight is not only beneficial for your overall health but also for your eye health. Obesity increases the risk of systemic conditions, such as diabetic eye disease or glaucoma, which can lead to vision loss.

Wear Protective Eyewear

Whenever you engage in sports or activities at home that pose a risk to your eyes, make sure to wear protective eyewear. This includes safety glasses, goggles, safety shields, and eye guards designed for specific activities. These protective eyewear options typically use exceptionally durable polycarbonate lenses.

Avoid Smoking

Smoking is detrimental to both your overall health and your eyes. It has been linked to an increased risk of age-related macular degeneration, cataracts, and optic nerve damage, which can ultimately lead to blindness.

Invest in Quality Sunglasses

Sunglasses serve as a fashionable accessory, but their primary role is to shield your eyes from harmful ultraviolet (UV) rays. Look for sunglasses that block out 99 to 100 percent of both UV-A and UV-B radiation for maximum protection.

Give Your Eyes a Break

If you find yourself spending extended periods focusing on a screen or any one task, remember to take regular breaks to reduce eyestrain. The 20-20-20 rule is a helpful guideline: every 20 minutes, shift your focus to something approximately 20 feet away from you for at least 20 seconds.

Maintain Good Hygiene for Contact Lenses

If you wear contact lenses, proper hygiene is crucial. Always wash your hands thoroughly before inserting or removing your lenses. Follow the recommended disinfection and replacement protocols to avoid the risk of eye infections.

Prioritize Workplace Eye Safety

If your job requires protective eyewear, make wearing the appropriate eyewear a routine part of your workday. Encourage your coworkers to do the same to ensure a safe work environment.

Consume a Balanced Diet

Eating a diet rich in fruits and vegetables, especially dark leafy greens like spinach and kale, is essential for eye health. Additionally, incorporating omega-3 fatty acids found in fish like salmon, tuna, and halibut can provide significant benefits for your eyes.

Schedule Comprehensive Eye Exams

Even if your vision seems fine, regular comprehensive dilated eye exams conducted by an eye care professional are crucial. These exams are the only way to detect common vision problems, and they help in the early identification of eye diseases such as glaucoma, diabetic eye disease, and age-related macular degeneration.

By following these simple yet effective guidelines, you can maintain good visual acuity and protect your eyes, ultimately ensuring a lifetime of clear and healthy vision.

About the LifeDNA Nutrition Report

LifeDNA’s Vitamins & Supplements Report is your tailored blueprint for enhancing your visual acuity based on your unique genetic makeup. This report delves into your genetic predispositions, offering personalized guidance to optimize your visual acuity.

Learn if your genetic profile suggests a higher likelihood of visual acuity concerns and take the initial step towards achieving optimal visual performance with the LifeDNA Vitamins & Supplements Report. Start your journey today!

Summary

  • Visual acuity measures a person’s ability to discern fine details and is often described as a “20/20” vision.
  • Comprehensive dilated eye exams are necessary to assess visual acuity, diagnose eye diseases, and detect vision changes.
  • Genetic factors, including Single Nucleotide Polymorphisms (SNPs), influence visual acuity, and SNPs are associated with conditions like Primary Open-Angle Glaucoma (POAG).
  • Non-genetic factors, such as refractive errors, pupil size, illumination, time of exposure, and eye movement, also affect visual acuity.
  • Correction methods include single vision lenses, under-correction, bifocals, progressive addition lenses (PALs), contact lenses, pharmaceutical agents, and LASIK surgery.
  • To maintain good visual acuity, manage diabetes (if relevant), maintain a healthy weight, wear protective eyewear, avoid smoking, use UV-protective sunglasses, take breaks to reduce eyestrain, practice proper contact lens hygiene, and eat a balanced diet.

References

  1. https://www.ncbi.nlm.nih.gov/books/NBK11509/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069781/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368730/
  4. https://iovs.arvojournals.org/article.aspx?articleid=2729028
  5. https://iovs.arvojournals.org/article.aspx?articleid=2729028
  6. https://iovs.arvojournals.org/article.aspx?articleid=2729028
  7. https://iovs.arvojournals.org/article.aspx?articleid=2729028
  8. https://www.ncbi.nlm.nih.gov/books/NBK11509/
  9. https://nursinganswers.net/essays/factors-affecting-visual-acuity.php
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729053/
  11. https://www.ncbi.nlm.nih.gov/books/NBK555970/
  12. https://www.cdc.gov/visionhealth/risk/tips.htm

Customer Reviews

Christopher Devlin
Christopher Devlin
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I am so impressed with this service. I have even discussed these recommendations with my health care providers and they are all impressed too! I can’t compare it with other services as I have only tried this but I recommend. Also I think I pulled my genetics in from ancestry too which was super convenient.
Lei'a
Lei'a
LifeDNA Customer
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Great source of information I was looking for a platform to make use of my existing raw data from Ancestry. I’m glad I found LifeDNA. I originally took a DNA test to learn about my roots and it’s great to know that my DNA could also play a big role in my health, diet, and even my skin. Overall, all the reports are incredible.
Shiraz Dole
Shiraz Dole
LifeDNA Customer
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It is crazy how I felt that I had a strong understanding of my bodies needs, but after having my DNA analyzed by the LifeDNA team, I realized that there was so much I still did not know.
Doc Sheila Lim
Doc Sheila Lim
LifeDNA Customer
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I got some pretty useful insight that helped me with my diet.
Previous
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*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Alcohol Addiction Genetics: What You Need To Know

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Alcohol Addiction Genetics: What You Need To Know

Date of Content: October 3, 2023
Written by: Jess Gayo
Reviewed by: Maarit Tiirikainen, PhD

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What is Alcohol Addiction?

Overview

While a glass of wine every now and again is perfectly fine for many adult individuals, frequent alcohol consumption in large quantities can lead to problems in the future. An individual with alcohol addiction, also known as alcoholism or alcohol use disorder (AUD), consumes alcohol compulsively and uncontrollably despite the harmful effects. Millions of people around the world are impacted by this intricate medical and psychological problem. 

Genetic, environmental, and psychological variables all play a role in the emergence of alcohol addiction. Some people may be genetically prone to developing alcohol use disorder (AUD). In contrast, environmental factors like peer pressure, traumatic events, or easy access to alcohol can also hasten this disorder’s start. It is possible that psychological issues such as stress, worry, and sadness are also important.

Numerous issues with one’s physical and mental health might result from alcoholism. Chronic alcohol usage increases the risk of diseases like dementia, cardiovascular disease, and liver cirrhosis by harming the brain, heart, and liver. Additionally, it may exacerbate mental health conditions including anxiety and sadness. Fortunately, alcohol addiction is treatable and manageable with the help of different treatments.

alcohol addiction

Why is Alcohol Addiction a Problem?

Alcoholism is a serious issue with wide-ranging effects that have an impact on society as a whole as well as on individuals. This syndrome is linked to a number of serious health issues. It can cause neurological abnormalities, cardiovascular problems, several types of cancer, and liver cirrhosis. These health problems not only reduce a person’s quality of life but also heavily tax healthcare systems.

Aside from its negative impacts on the individual, alcoholism also has a negative impact on society as a whole, including problems like family dissolution, domestic abuse, and neglect of children. Additionally, it has a major economic impact because of the billions of dollars in annual costs associated with addiction-related healthcare, lost productivity, and legal charges. Additionally, driving under the influence is a major factor in deadly accidents and traffic fatalities all over the world. Alcohol addicts are more likely to participate in risky behaviors, such as impaired driving and the endangerment of other road users as well as themselves.

Hereditary or Developed: What Causes Alcohol Addiction?

The complicated condition known as alcohol use disorder (AUD) is influenced by a number of hereditary, environmental, and psychological variables. Alcohol addiction is significantly influenced by genetics. Some people can be more prone to developing AUD because of a hereditary predisposition. A person’s risk can be raised by a family history of alcoholism. Alcohol addiction can also be influenced by external elements from the environment, such as social, cultural, and economic issues. Alcoholism that is excessive can be encouraged by peer pressure, easy access to alcohol, and exposure to a drinking culture.

Genetic Causes

Alcohol addiction has extensive and complicated genetic roots that involve several genes and their interactions. Although there isn’t just one “alcohol addiction gene,” scientists have found a number of genetic markers and variations that are linked to an elevated risk of AUD.

Alcohol Metabolism Genes

ADH (Alcohol Dehydrogenase) Genes

The rate at which a person metabolizes alcohol might vary depending on genetic variations in the enzymes that code for alcohol dehydrogenases, which are in charge of breaking down alcohol in the body. Some people have a genetic predisposition to metabolize alcohol more slowly, which can increase the risk of AUD when exposed to alcohol for a longer period of time.

ALDH (Aldehyde Dehydrogenase) Genes

Similarly, variations in aldehyde dehydrogenase gene expression can affect how alcohol is metabolized. A poisonous chemical called acetaldehyde, which can accumulate more with certain genetic variations, can cause unpleasant effects such as nausea and face flushing. These unpleasant side effects can make drinking less appealing and lower the chance of addiction.

GABAergic and Glutamatergic Systems

GABRA2 (Gamma-Aminobutyric Acid Receptor Alpha 2) Gene

AUD susceptibility has been connected to variations of this gene. The GABAergic system, which is involved in reducing brain activity, is influenced by GABRA2. This system’s dysregulation can be a factor in alcohol dependence and cravings.

GRM7 (Glutamate Metabotropic Receptor 7) Gene

AUD has also been linked to genetic polymorphisms in GRM7, a component of the glutamatergic system. Excitatory neurotransmitter glutamate is implicated in reward pathways, and flaws in this system can affect the likelihood of developing alcohol addiction.

Reward and Dopaminergic Pathways

DRD2 (Dopamine Receptor D2) Gene

There is a correlation between higher susceptibility to addictive behaviors, especially alcohol addiction, and genetic variations in the DRD2 gene, which is associated with dopamine receptors in the brain. Dopamine is a neurotransmitter linked to reward and pleasure, and changes in how it is regulated can lead to addictive behaviors.

Opioid System

OPRM1 (Opioid Receptor Mu 1) Gene

Differences in reward response and alcohol sensitivity have been linked to variations in the OPRM1 gene. Some variations may increase a person’s susceptibility to alcohol’s rewarding effects, raising the likelihood of addiction.

Neurotransmitter Transporters

SLC6A3 (Dopamine Transporter) Gene

Dopamine modulation in the brain may be impacted by genetic differences in SLC6A3, the dopamine transporter. Changes in dopamine transport may affect a person’s propensity to get addicted to alcohol.

Other Genetic Markers for AUD

In LifeDNA’s alcohol consumption report, researchers study other genetic markers for AUD including ADH1B (rs1229984), ADH1B (rs1789891), ADH1B (rs1229984), MTIF2, PRORSD1P (rs1437396), ADH7, ADH1B (rs4699741), ADH1B (rs2066702), PECR, MREG (rs7590720), SERINC2 (rs4478858), KIAA0040 (rs6425323), and THSD7B (rs1869324).

These genetic risk factors alone do not predict the onset of alcoholism. An individual’s risk is influenced by genetic, environmental, psychological, and social factors. Furthermore, genetics cannot fully account for the intricacy of alcohol addiction on its own. In order to develop a more complete knowledge of AUD, researchers are still investigating the complex interactions between genetics and other factors. For people at risk of alcohol addiction, this knowledge can inform preventative measures and individualized treatment plans.

Non-Genetic or Environmental Causes

The onset of alcohol addiction is largely influenced by genetics, but an individual’s susceptibility to AUD is also greatly influenced by environmental circumstances. The complicated nature of AUD is a result of the interaction between genetic predispositions and these non-genetic or environmental causes.

Early Exposure and Family Environment

  • Early Exposure to Alcohol: Young people who are exposed to alcohol, especially during adolescence, are more likely to acquire AUD. Early alcohol consumption can pave the way for persistently harmful drinking practices.
  • Family Environment: Growing up in a household where alcohol abuse is common can raise a person’s risk of acquiring AUD. One’s attitudes regarding alcohol can be influenced by familial variables such as parental drinking habits, family dynamics, and “normalization” of alcohol usage.

Peer Influence and Accessibility

  • Peer Pressure: Young adults and adolescents are especially susceptible to peer pressure when it comes to alcohol use. Individuals may indulge in unsafe drinking habits and run a higher risk of developing an addiction if their social groups encourage heavy drinking.
  • Easy Access to Alcohol: The pricing and accessibility of alcohol can have a big impact on how much people drink. People who live in locations where alcohol is easily accessible or who have easy access to it may be more likely to engage in excessive drinking.

Stress and Trauma

  • Psychological Factors: People may use alcohol as a coping method in response to environmental stressors such as interpersonal issues, work-related stress, and academic pressure. Alcohol can momentarily relieve emotional distress, which might help AUD develop.
  • Traumatic Experiences: Trauma, such as physical or sexual abuse, increases the likelihood of developing AUD in those who have experienced it. Self-medication with alcohol can be done to numb emotional anguish.
  • Financial Stress: Addiction to alcohol can be exacerbated by financial stress and hardship. People who are struggling financially could use alcohol as a temporary distraction from their issues.

Cultural and Social Factors

  • Cultural Norms: An individual’s drinking habits might be influenced by cultural attitudes and expectations toward alcohol consumption. Heavy drinking might be more socially acceptable in some cultures, which would increase the prevalence of AUD.
  • Media Influence: Alcohol usage can be glamorized through media and advertising representations, which can have an impact on social beliefs and behavior.
  • Lack of Education: Ineffective preventive measures and a lack of knowledge about the dangers of excessive alcohol use can both contribute to AUD. To reduce alcohol abuse, education, and awareness initiatives are crucial.

It is important to understand these non-genetic and environmental factors of AUD when creating effective alcohol addiction prevention plans and interventions. These factors emphasize the necessity for all-encompassing strategies that take into account a person’s genetic susceptibility as well as the environmental elements that can initiate and sustain problematic drinking behaviors.

What are the Symptoms of AUD?

Alcohol use disorder symptoms can range in severity but frequently include an increased tolerance for alcohol, withdrawal symptoms from alcohol, unsuccessful attempts to reduce or control alcohol use, neglecting important responsibilities because of drinking, and continued alcohol use despite negative effects on relationships and health. The individual’s urge for alcohol may gradually take over more and more of their daily activities.

Individuals with AUD often find it challenging to limit the amount or duration of their alcohol consumption, frequently drinking more or for longer periods than intended. AUD also creates a strong desire or urge to drink alcohol, leading individuals to prioritize alcohol over other activities and responsibilities. Over time, individuals may develop a tolerance to alcohol, meaning they need to consume more to achieve the desired effects or experience the same level of intoxication.

When not drinking or attempting to cut down, individuals with AUD may experience withdrawal symptoms such as anxiety, nausea, sweating, shakiness, and even seizures. These symptoms often drive individuals to continue drinking. People with AUD may also neglect important work, school, or family obligations due to their alcohol use, jeopardizing relationships and their overall well-being.

Is Alcohol Addiction Considered a Mental Disorder?

In the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), which is a widely accepted classification system used by mental health professionals, alcohol addiction is diagnosed as Alcohol Use Disorder (AUD). AUD is a recognized mental health condition characterized by a problematic pattern of alcohol use leading to significant distress or impairment in various areas of an individual’s life.

AUD encompasses a range of symptoms and severity levels, from mild to severe, based on the number of diagnostic criteria met. Alcohol addiction is considered a mental disorder for several reasons including its psychological components such as cravings, preoccupation with alcohol, and the use of alcohol to cope with emotional distress. These elements are characteristic of many mental health disorders. Impaired Functioning is also common in people with AUD. They often experience impairment in various aspects of their lives, including work, relationships, and social activities, which aligns with the definition of a mental disorder.

AUD may also cause neurobiological changes. Long-term alcohol abuse can lead to significant changes in the brain’s structure and function, affecting decision-making, impulse control, and emotional regulation—further supporting its classification as a mental disorder. This condition also frequently co-occurs with other mental health disorders such as depression, anxiety, and post-traumatic stress disorder, highlighting its interconnectedness with mental health. Moreover, AUD is typically diagnosed and treated by mental health professionals, including psychiatrists, psychologists, and addiction counselors, further solidifying its status as a mental disorder.

The Road to Recovery: Treatment Options for Alcohol Addiction

AUD, like many mental disorders, is a treatable condition. Various therapeutic approaches, including psychotherapy, medication, and support groups, are available to help individuals manage their alcohol addiction and work toward recovery. Treatment options include controlled detoxification, rehabilitation programs that focus on therapy, and counseling to address the psychological aspects of addiction. Support groups like Alcoholics Anonymous (AA) provide ongoing assistance and a sense of community for individuals in recovery.

Detoxification (Detox)

  • The initial stage of treating AUD is detoxification, which entails properly controlling withdrawal symptoms as the body gets rid of alcohol. To assure the person’s safety and comfort, this procedure is frequently carried out under medical supervision.

Medications

  • Acamprosate: It helps balance brain chemicals affected by long-term alcohol use and can reduce cravings.
  • Disulfiram: This medication creates unpleasant reactions (e.g., nausea and vomiting) when alcohol is consumed, acting as a deterrent.
  • Naltrexone: Naltrexone can reduce the rewarding effects of alcohol, making it less appealing.
  • Nalmefene: Similar to naltrexone, it can reduce alcohol cravings and consumption.

Behavioral Therapies

  • Cognitive Behavioral Therapy (CBT): Helps individuals identify and change unhealthy thought patterns and behaviors related to alcohol use.
  • Motivational Enhancement Therapy (MET): A goal-oriented approach focused on enhancing an individual’s motivation to change their drinking behavior.
  • Contingency Management: Rewards individuals for maintaining sobriety and participating in treatment.

Counseling

  • Individual Counseling: One-on-one counseling provides a confidential and supportive environment for individuals to explore the underlying causes of their addiction and develop strategies for recovery.
  • Group Therapy: Group therapy sessions allow individuals to share their experiences, receive support, and learn from others facing similar challenges. It fosters a sense of community and understanding.
  • Family Therapy: Family therapy addresses the impact of AUD on family dynamics and relationships. It involves counseling for family members to improve communication, set boundaries, and support the recovery process.
  • Self-Help and Support Groups: Joining support groups like Alcoholics Anonymous (AA) or SMART Recovery can provide ongoing peer support and a sense of belonging during recovery.

Holistic Approaches

  • Complementary therapies such as yoga, meditation, and mindfulness techniques can help individuals manage stress and promote overall well-being.

Treatment Programs

  • Inpatient or Residential Treatment Program: For severe cases of AUD, inpatient or residential treatment programs provide a highly structured and immersive environment where individuals receive intensive therapy and support.
  • Outpatient Treatment: Outpatient programs offer flexibility for those with milder forms of AUD, allowing individuals to attend therapy sessions while maintaining their daily routines.

Achieving and maintaining sobriety is a challenging but rewarding process. Recovery from alcohol addiction often involves ongoing therapy, lifestyle changes, and building a strong support network. Relapses may occur, but they should be seen as setbacks rather than failures, as many people experience multiple attempts before achieving lasting sobriety.

LifeDNA’s Report on Alcohol Consumption

Numerous diseases have alcohol use as a risk factor. More than 200 diseases and health issues include it as a component cause. The danger linked with drinking alcohol is, however, largely adjustable through leading a healthy lifestyle because alcohol follows a dose-response connection for the risk of mortality or sickness. 

You can learn more about your risk of Alcohol Dependence and risky Alcohol Consumption tendencies by understanding its genetic components. LifeDNA’s Wellness Report gives insight into several traits that can help you understand how and why you can develop certain substance dependence such as excessive alcohol consumption. Get yours here.

Summary

  • Alcohol addiction, commonly known as alcoholism or alcohol use disorder (AUD), is the obsessive and uncontrollable consumption of alcohol despite its negative effects.
  • Alcohol addiction can develop for a variety of reasons, including genetic, environmental, and psychological factors. A hereditary predisposition to developing alcohol consumption disorder (AUD) may exist in some individuals.
  • Alcoholism can impair the liver, heart, and brain, which can lead to a variety of problems with one’s physical and mental health, such as liver cirrhosis, cardiovascular disease, and dementia.
  • Alcoholism has harmful effects on both the person and society as a whole. These effects include issues such as family breakdown, domestic violence, and child maltreatment.
  • Recovery from alcohol addiction often involves ongoing therapy, lifestyle changes, and building a strong support network. Relapses may occur but these don’t need to mean failure of recovery.

References

  1. https://alcohol.org/alcoholism-types/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860432/#:~:text=Studies%20have%20shown%20that%20people,with%20the%20risk%20of%20alcoholism.
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447097/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575093/
  5. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/gabra2#:~:text=GABAA%20Receptors,A%20receptor%2C%20with%20alcohol%20dependence.
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617339/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123698/
  8. https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-11-24#:~:text=The%20dopamine%20D2%20receptor%20(DRD2,and%20craving%20in%20alcoholic%20patients.
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469933/
  10. https://pubmed.ncbi.nlm.nih.gov/19450132/
  11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335908/
  12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277871/
  13. https://americanaddictioncenters.org/addiction-medications/disulfiram
  14. https://www.alcoholrehabguide.org/treatment/naltrexone/#:~:text=Naltrexone%20is%20a%20prescribed%20medication,of%20a%20comprehensive%20treatment%20plan.
  15. https://rehabclinicsgroup.com/medications/treating-alcohol-addiction-using-nalmefene/#:~:text=Nalmefene%20is%20a%20type%20of,don’t%20need%20immediate%20detoxification.
  16. https://alcohol.org/therapy/cbt/
  17. https://www.addictioncenter.com/treatment/motivational-enhancement-therapy/
  18. https://www.alcoholrehabguide.org/treatment/types-therapy-alcoholism/
  19. https://www.addictioncenter.com/treatment/holistic-therapy/
  20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561398/
  21. https://www.ptsd.va.gov/understand/related/problem_alcohol_use.asp#:~:text=Trauma%20and%20PTSD%20Can%20Lead%20to%20Problems%20with%20Alcohol&text=Up%20to%20a%20third%20of,ongoing%20health%20problems%20or%20pain.
  22. https://pubmed.ncbi.nlm.nih.gov/7950847/#:~:text=After%20control%20for%20these%20factors,before%20the%20age%20of%2013.

Customer Reviews

Christopher Devlin
Christopher Devlin
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I am so impressed with this service. I have even discussed these recommendations with my health care providers and they are all impressed too! I can’t compare it with other services as I have only tried this but I recommend. Also I think I pulled my genetics in from ancestry too which was super convenient.
Lei'a
Lei'a
LifeDNA Customer
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Great source of information I was looking for a platform to make use of my existing raw data from Ancestry. I’m glad I found LifeDNA. I originally took a DNA test to learn about my roots and it’s great to know that my DNA could also play a big role in my health, diet, and even my skin. Overall, all the reports are incredible.
Shiraz Dole
Shiraz Dole
LifeDNA Customer
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It is crazy how I felt that I had a strong understanding of my bodies needs, but after having my DNA analyzed by the LifeDNA team, I realized that there was so much I still did not know.
Doc Sheila Lim
Doc Sheila Lim
LifeDNA Customer
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I got some pretty useful insight that helped me with my diet.
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*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Antioxidant Status: The Role of DNA

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The Genetics Of Antioxidants

Date of Content: October 9, 2023
Written by: Avanthika Nityanand
Reviewed by: Maarit Tiirikainen, PhD

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What Are Antioxidants?

Antioxidants are molecules that neutralize free radicals in the body. Free radicals are compounds that can cause harm if their levels become too high. They come from various sources, including food, medicines, tobacco smoke, radiation, and various biological processes of the body.

Antioxidant Status

What Do Antioxidants Do?

Free radicals are unstable atoms that can damage cells, thus contributing to aging and diseases. Antioxidants neutralize these harmful free radicals, preventing cellular and DNA damage. The body has its system of providing antioxidants but also sources them from our diet – primarily through fruits, vegetables, and certain types of meat and fish.

According to the National Center for Complementary and Integrative Health, dietary antioxidants include:

Are Antioxidants Good for You?

Generally, a balanced diet rich in fruits and vegetables – good sources of antioxidants – is most beneficial. Studies show a strong correlation between a diet rich in antioxidants and a reduced risk of chronic diseases like heart disease, cancer, and neurodegenerative diseases.

Protection Against Reactive Oxygen Species

At the cellular level, metabolic processes generate reactive oxygen species (ROS), potentially harmful molecules capable of damaging cellular components, including DNA, proteins, and lipids. Over time, organisms developed antioxidant systems as a defense mechanism against ROS. These systems help maintain cellular integrity and function.

Mitochondrial Function

Mitochondria, often referred to as the powerhouses of the cell, play a critical role in making energy for the cells. While essential for life, this process also produces ROS as a byproduct. Antioxidants help protect mitochondria from ROS-induced damage, ensuring efficient energy production and cellular survival.

Adaptation and Survival

In evolutionary history, environmental stress factors, such as exposure to high radiation levels from the sun, could lead to increased ROS production. Organisms with effective antioxidant systems had a survival advantage, as they could better manage oxidative stress, leading to improved cellular function, DNA integrity, and overall survival.

Complex Antioxidant Systems

Evolution favored organisms with diverse antioxidants, enabling them to respond to various oxidative challenges. This is evident in various antioxidant systems in modern organisms, including enzymes like superoxide dismutase, catalase, and glutathione peroxidase and non-enzymatic molecules like vitamins C, E, and beta-carotene.

Antioxidant-rich Diets and Human Evolution

As early human diets were rich in fruits, vegetables, and other plant-based foods, the intake of dietary antioxidants likely played a role in human evolution. A diet rich in antioxidants could have protected against oxidative stress, supporting overall health, longevity, and reproductive success.

Vitamin C as an Antioxidant

Vitamin C, also known as ascorbic acid, is a potent antioxidant to safeguard against oxidative stress. It also plays a role in collagen production, wound healing, and maintaining cartilage, bones, and teeth. Fruits like oranges, strawberries, and kiwi are abundant sources of vitamin C.

Genetics of Antioxidant Status

Our genetic makeup plays a vital role in determining our body’s antioxidant status, influencing the production of natural antioxidants and the response to antioxidants obtained from dietary sources. A deeper understanding of this relationship has emerged from studying gene polymorphisms related to antioxidant enzymes and their respective functions.

Several genes encoding for antioxidant enzymes have been identified, and their polymorphisms can have profound implications for health and susceptibility to oxidative stress:

SOD (Superoxide Dismutase)

Superoxide dismutases (SODs) are special enzymes in all life forms, from bacteria to humans. Their main job is to protect cells from harmful ROS. Think of ROS as tiny invaders that can harm our cells. SODs defend against these invaders by breaking down a harmful ROS called the superoxide anion free radical (O2-). They convert this harmful molecule into two less harmful substances: regular oxygen that we breathe and hydrogen peroxide. By doing this, SODs help maintain a balance in our cells and prevent excessive amounts of damaging ROS from accumulating.

Different genes encode the three forms of SOD (SOD1, SOD2, SOD3), and polymorphisms in these genes can influence antioxidant capacity. The SOD2 gene polymorphism, Ala16Val (rs4880), in exon 2 is well-studied. This particular single nucleotide polymorphism (SNP) swaps the amino acid at the 16th position from valine (Val) to alanine (Ala). Numerous studies have linked the Ala16Val SNP with variations in the SOD2 enzyme activity, influencing disease progression and risk, including this 2016 meta-analysis. 

CAT (Catalase)

The CAT gene encodes for the enzyme catalase, which helps convert hydrogen peroxide, a potential ROS, into water and oxygen. A lack or dysfunction of catalase is theorized to contribute to the onset of several age-related conditions, including cancer, diabetes mellitus, hypertension, anemia, Alzheimer’s disease, Parkinson’s disease, and other chronic conditions such as vitiligo, bipolar disorder, and schizophrenia.

Variations in the CAT gene can lead to differing levels of catalase enzyme activity in the body. A 2016 meta-analysis reviewed the correlation between two prevalent catalase gene polymorphisms (rs1001179 and rs794316) and cancer risk. This analysis encompassed 37 published studies, totaling 14,942 cancer patients and 43,285 individuals without cancer.  Both polymorphisms were associated with an increased cancer risk.

GPX (Glutathione Peroxidase)

This family of enzymes, particularly GPX1, encodes the GPx-1 protein. GPx-1 targets hydrogen peroxide, a molecule that can cause damage to our bodies. GPx-1 converts hydrogen peroxide into water. Specific polymorphisms in the GPX1 gene can affect the activity of the GPx-1 protein and, subsequently, the body’s ability to neutralize ROS.

The GPX1 polymorphism Pro198Leu genotype was examined in 82 individuals with prostate cancer and 123 controls. The researchers identified a protective effect from the variant Leu allele of the GPX1 polymorphism against the risk of prostate cancer. Individuals heterozygous for the variant Leu allele exhibited a notably reduced risk of prostate cancer compared to those homozygous for the wild-type.

GST (Glutathione S-transferase)

GST enzymes, encoded by the GST family of genes like GSTM1 and GSTT1, assist in detoxifying and neutralizing certain oxidants. Deletions or null polymorphisms in these genes are associated with reduced enzyme activity and increased susceptibility to oxidative stress-related conditions.

A meta-analysis study indicated that individuals possessing the GSTM1 null genotype, or having both GSTM1 and GSTT1 null genotypes, or those with the GSTT1 null genotype in combination with the GSTP1 A131G variation are at an increased risk of developing prostate cancer.

A 2018 study showed that the absence of the GSTM1 gene was related to a greater likelihood of colorectal cancer spreading to the lymph nodes. The same study also demonstrated that variation in the GSTT1 gene was linked to a higher severity of tumors in colorectal cancer patients.

Section Summary

Understanding these genetic polymorphisms is vital as they provide insight into individual variability in antioxidant capacity and potential disease susceptibility. As personalized medicine and genomics continue to advance, leveraging this genetic information can lead to tailored dietary and therapeutic strategies to optimize antioxidant status for individuals.

Non-genetic Factors Influencing Antioxidant Status

Various environmental and lifestyle factors can impact an individual’s antioxidant status. These include:

  • Diet: As the primary external source of antioxidants, what you eat significantly affects your antioxidant levels.
  • Smoking and Alcohol: Both can increase oxidative stress, depleting the body’s antioxidant reserves.
  • Exposure to Pollution: Living in high-pollution areas can increase the number of free radicals in the body.
  • Medications: Some medicines can decrease antioxidant levels or increase free radical production.

How To Improve Your Antioxidant Levels Naturally

Naturally enhancing antioxidant levels is pivotal for optimal health since antioxidants help neutralize free radicals, which can damage cells and contribute to aging and diseases. Here are ways to boost your antioxidant levels naturally:

Eat a Colorful Diet

Fruits and Vegetables

Aim for a variety of colors in your diet. Each color often represents different antioxidant compounds. Blueberries, strawberries, raspberries, blackberries, cherries, grapes, apples, oranges, and pomegranates are particularly rich in antioxidants. Vegetables like kale, spinach, broccoli, bell peppers, beets, carrots, and tomatoes also contain high amounts.

Nuts and Seeds

Almonds, walnuts, flaxseeds, chia, and sunflower seeds are good sources of natural antioxidants

Consume Whole Grains

Grains like quinoa, brown rice, oats, barley, and whole wheat offer beneficial antioxidants.

Herbs and Spices

Spices like turmeric, cloves, cinnamon, oregano, rosemary, and herbs like basil and parsley have antioxidant properties.

Drink Green Tea

Green tea contains antioxidants called catechins that are associated with numerous health benefits.

Include Omega-3 Fatty Acids

Foods rich in omega-3s, like fatty fish (salmon, mackerel, sardines), walnuts, and flaxseeds, have antioxidant properties.

Eat Fermented Foods

Fermented foods like yogurt, kefir, sauerkraut, kimchi, and kombucha are rich in antioxidants and support gut health.

Limit Processed Foods and Sugars

Processed foods can increase oxidative stress. Stick to natural, whole foods.

Limit Alcohol Intake

While moderate consumption of red wine can provide antioxidants like resveratrol, excessive alcohol can increase oxidative stress.

Stay Active

Regular exercise can boost your body’s production of natural antioxidants and help protect cells. Avoid smoking and reduce exposure to environmental pollutants, since these can increase free radical production.

Manage Stress

Chronic stress can result in oxidative stress. Engage in relaxation techniques like meditation, deep breathing exercises, or yoga.

Get Adequate Sleep

Sleep is a time of restoration for the body. Aim for 7-9 hours of quality sleep each night.

Stay Hydrated

Drinking enough water can support your body’s natural detoxification processes.

About the LifeDNA Nutrition Report

The Nutrition Report from LifeDNA offers genetically tailored nutrition insights that can help optimize your wellness. The report delves into your unique genetic predispositions to provide dietary recommendations from macro to micronutrients. Do you have a higher genetic likelihood for lactose intolerance or gluten sensitivity, or how well your body metabolizes caffeine? 

The LifeDNA Nutrition report includes an analysis of Antioxidant Status. Get yours here.

Summary

  • Antioxidants play a crucial role in neutralizing harmful free radicals in the body. 
  • While they can derive from natural bodily processes and dietary intake, their importance in combating various diseases is undeniable. 
  • Both genetic and non-genetic factors can influence an individual’s antioxidant status. 
  • While antioxidant supplements are available, sourcing them from natural food sources and maintaining a balanced lifestyle is the best approach for most people.

References

Customer Reviews

Christopher Devlin
Christopher Devlin
LifeDNA Customer
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I am so impressed with this service. I have even discussed these recommendations with my health care providers and they are all impressed too! I can’t compare it with other services as I have only tried this but I recommend. Also I think I pulled my genetics in from ancestry too which was super convenient.
Lei'a
Lei'a
LifeDNA Customer
Read More
Great source of information I was looking for a platform to make use of my existing raw data from Ancestry. I’m glad I found LifeDNA. I originally took a DNA test to learn about my roots and it’s great to know that my DNA could also play a big role in my health, diet, and even my skin. Overall, all the reports are incredible.
Shiraz Dole
Shiraz Dole
LifeDNA Customer
Read More
It is crazy how I felt that I had a strong understanding of my bodies needs, but after having my DNA analyzed by the LifeDNA team, I realized that there was so much I still did not know.
Doc Sheila Lim
Doc Sheila Lim
LifeDNA Customer
Read More
I got some pretty useful insight that helped me with my diet.
Previous
Next

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Unraveling Testosterone Genetics: Insights into Male Hormonal Traits

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Testosterone Genetics: Insights into Male Hormonal Traits

Date of Content: October 1, 2023
Written by: Jess Gayo
Reviewed by: Maarit Tiirikainen, PhD

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What is Testosterone?

Overview

Contrary to popular belief, testosterone is present in both males and females, albeit in different quantities. This hormone is a vital hormone primarily associated with male reproductive and sexual development. This steroid hormone belongs to a class of hormones known as androgens and plays a multifaceted role in the human body.

While the ovaries produce some testosterone in females, the testes are the main site of production in males. In addition, both genders’ adrenal glands provide a small but significant contribution to the creation of testosterone.

Male testosterone levels rise during adolescence, which causes the emergence of secondary sexual traits such as facial hair growth, voice deepening, increased muscle mass, and the development of the cartilage that covers the front of your larynx or your “Adam’s apple.” Additionally, it supports the development and upkeep of the prostate and other male reproductive organs.

testosterone genetics

Testosterone Beyond the Reproductive System

In addition to helping in sexual development, testosterone has a variety of other purposes in the body. It is essential for general physical strength and health since it plays a significant part in preserving bone density and muscle mass. Low levels of testosterone have been linked to symptoms including weariness and sadness. Testosterone also affects mood and cognitive abilities.

A person’s total energy levels and endurance can be impacted by the regulation of red blood cell synthesis (erythropoiesis), which is one of the functions of testosterone. Testosterone also contributes to the preservation of a healthy metabolism, affects how fat is distributed and might have an impact on overall body composition.

Both men and women experience a fall in testosterone levels as they age, a process known as andropause in males or menopause in women. Reduced libido, erectile dysfunction in males, and both sexes, decreased muscle mass, increased body fat, and mood problems, are just a few of the symptoms that can result from low testosterone levels.

Patients with definite medical disorders or hormone deficits may be prescribed testosterone therapy in medical settings. However, because overuse or abuse of such treatments might have negative effects, it is imperative to utilize them under the guidance of a skilled healthcare practitioner. For sustaining general health and energy throughout one’s life, keeping well-regulated testosterone levels is essential.

What Causes the Production of Testosterone?

Numerous factors, including biological and environmental aspects, have a substantial impact on testosterone levels in the human body. A person’s living circumstances can have an impact on the carefully controlled systems that produce and regulate testosterone. 

Men’s testosterone levels are influenced by age, smoking, and obesity and are linked to cardiovascular disease, osteoporosis, and mortality. While age and genetic variables affect testosterone levels at rest, additional elements like lifestyle, nutrition, exercise, stress, and particular medical problems can either increase or decrease testosterone production. 

It is crucial to know the reasons behind testosterone fluctuations because imbalances can cause a variety of health problems, including sexual dysfunction, mood swings, and changes in bone and muscle mass.

Genetic Factors

Multiple genes and complex genetic markers are connected to testosterone levels and how they affect the body. No single “testosterone level gene” exists, although several genetic variables can affect testosterone production, control, and sensitivity. 

Sex Hormone-Binding Globulin (SHBG)

Significant variations in testosterone levels and an increased risk of low testosterone are linked to several genetic variations in the SHBG gene locus on chromosome 17. The first SHBG polymorphism to be identified, rs6258, affects how much testosterone binds to SHBG and how much is present as free testosterone. 

 

SHBG is a protein that binds to several sex hormones, including testosterone, in the bloodstream. Genetic variations in the SHBG gene can affect the level of SHBG produced, thereby influencing the amount of free, biologically active testosterone available to the body. An SNP in SHBG rs1799941 is a particularly studied one and is included in LifeDNA’s male testosterone report. 

FAM9B

Polymorphism at FAM9B (rs5934505) on the X chromosome is also linked to testosterone levels. 

SRD5A2 Gene

The SRD5A2 gene encodes an enzyme called 5-alpha reductase type 2, which is responsible for converting testosterone into its more potent form, dihydrotestosterone (DHT). Genetic variations in this gene can affect the rate at which this conversion occurs, potentially influencing the development of secondary sexual characteristics and hair growth.

Androgen Receptor (AR) Gene

The AR gene codes for the androgen receptor protein, which is responsible for binding to testosterone and DHT, allowing them to exert their effects on various tissues in the body. Genetic variations in the AR gene can influence how sensitive an individual’s tissues are to these hormones, impacting traits such as muscle development and hair growth.

CYP19A1 Gene

This gene encodes the enzyme aromatase, responsible for converting testosterone into estradiol, a form of estrogen. Variations in the CYP19A1 gene can influence the balance between testosterone and estrogen in the body, impacting traits like bone density and fat distribution.

FSHB and LHCGR Genes

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are crucial for regulating testosterone production in the testes. Genetic variations in the FSHB and LHCGR genes can affect the sensitivity of the testes to these hormones, ultimately influencing testosterone levels.

Genetics is just one factor, but various genetic markers can affect testosterone levels and their effects on the body. A person’s hormonal profile is, however, greatly influenced by their lifestyle choices, environmental influences, and general health. 

Non-Genetic or Environmental Factors

The levels of testosterone in both men and women can be dramatically influenced by environmental variables. These variables cover a wide spectrum of lifestyle, nutritional, behavioral, and environmental aspects that can influence hormonal balance and increase or reduce testosterone production. 

Age

With age, testosterone levels naturally decrease. Beginning in their late 20s to early 30s, men normally undergo a progressive reduction in testosterone, which persists as they age.

Diet and Nutrition

The amount of testosterone can be affected by dietary choices. To produce testosterone at its highest level, a diet rich in critical minerals including zinc, vitamin D, and healthy fats is recommended. Contrarily, a diet high in processed foods, sweets, and binge drinking can have a deleterious impact on hormone balance.

Physical Activity

Regular exercise can increase testosterone production, particularly strength training and high-intensity interval training. Conversely, leading a sedentary lifestyle may result in reduced testosterone levels.

Stress

The production of testosterone can be inhibited by ongoing stress and high levels of cortisol. These effects might be lessened with the aid of stress management practices like mindfulness and meditation.

Obesity

Increased levels of aromatase, an enzyme that changes testosterone into estrogen, can be brought on by excess body fat, particularly visceral fat. Lower testosterone levels in both men and women may result from excess weight.

Sleep and Rest

Poor quantity or regularity of sleep can affect testosterone levels negatively. Good hormonal balance depends on a regular sleep pattern with adequate sleep time.

Medications and Health Conditions

Opioids and corticosteroids are two drug groups that can have an impact on testosterone production. Hormonal imbalances can also be influenced by underlying medical problems like diabetes and metabolic disorders.

Chronic Illness and Trauma

The body’s capacity to produce testosterone may be negatively impacted either momentarily or permanently by serious illnesses, operations, or physical damage.

These variables may interact and differ from one person to the next. For instance, the combined effect of chronic stress and obesity can have a greater effect on testosterone levels than each cause acting alone. 

People can improve their testosterone levels and general health by leading a healthy lifestyle, controlling their stress, and consulting a doctor as needed. Consulting a healthcare provider to ascertain the underlying causes and suitable remedies is advised if someone suspects they have a hormonal imbalance.

Is Testosterone Present in Everyone?

Despite being usually identified with men, testosterone is a hormone that affects both sexes equally. Although testosterone levels in men tend to be much higher than in women, both sexes generate this vital hormone, albeit in different amounts and with slightly different physiological effects.

The principal site of testosterone production in males is the testes, which are also crucial in the puberty-related development of secondary male sexual traits. This entails the voice becoming deeper, the development of facial and body hair, an increase in muscle mass, and the enlargement of the Adam’s apple. Testes and the prostate, two male reproductive organs, are supported in their maintenance by testosterone.

Low amounts of testosterone are produced by the ovaries in females, which helps women to maintain a healthy overall hormonal balance. Testosterone helps women retain their sex desire, muscle mass, and bone density. But compared to men, the levels are substantially lower. The amount and effects of testosterone differ across the sexes, yet it is essential to both male and female physiology, affecting overall physical growth, as well as general health and well-being.

What are the Benefits of Balanced Testosterone Levels?

Balanced testosterone level offers a multitude of benefits for both men and women, influencing various aspects of physical, mental, and emotional health. 

Muscle Mass and Strength

Testosterone encourages the synthesis of muscle proteins, which is essential for gaining and preserving lean muscle mass. A healthy testosterone balance can improve athletic performance and muscle strength.

Bone Density

In maintaining healthy bones, testosterone is essential. In particular for elderly persons, adequate levels are needed for maintaining bone density and to lower the incidence of fractures and osteoporosis.

Libido and Sexual Function

For libido and general sexual function in both men and women, testosterone is necessary. Balanced levels can improve performance and sexual gratification.

Mood Regulation

The effects of testosterone on mood and cognitive ability are substantial. Adequate levels are linked to greater mood, a lower risk of depression, and better memory and focus among other cognitive skills.

Energy Levels

Energy and vigor rise when testosterone levels are balanced. People who have enough testosterone typically feel more motivated and energetic in general.

Optimal Metabolism and Fat Distribution

By encouraging the growth of lean muscle and controlling the distribution of fat, testosterone affects body composition. A healthy weight can be maintained and body fat can be decreased with adequate amounts of circulating testosterone. In addition to supporting a healthy metabolic rate and aiding in weight control, balanced testosterone levels can also help to prevent multiple issues associated with obesity.

Cardiovascular Health

By enhancing blood vessel function and lowering the risk of heart disease, testosterone helps to maintain good cardiovascular health.

Improved Quality of Life

Overall, normal testosterone levels encourage good physical health, mental well-being, and general vigor, all of which improve quality of life.

Having too little or too much testosterone can both have negative effects. Symptoms of low testosterone (hypogonadism) include weakness in the muscles, decreased libido, mood swings, and exhaustion. On the other hand, too high testosterone levels can lead to health-related problems like acne, aggressiveness, and a higher risk of cardiovascular diseases.

To maintain maximum health and well-being, testosterone levels must be kept in balance. To guarantee they can benefit from the many advantages of normal testosterone levels, it is advised for anyone who feels they may have a hormonal imbalance to visit a healthcare expert for examination and appropriate management.

How to Naturally Increase Testosterone

Through various lifestyle choices and practices that support hormonal balance, one can naturally raise testosterone levels. While it’s crucial to seek the advice of a medical practitioner for your particular situation, there are some broad methods to increase testosterone naturally.

Dietary Choices

  • Eat Nutrient-Rich Foods: Consume a balanced diet full of whole foods, including lean proteins, healthy fats, and a range of fruits and vegetables. Eat nutrient-rich foods that offer important vitamins and minerals like vitamin D, zinc,  and omega-3 fatty acids that support the creation of testosterone.
  • Limit Sugar and Processed Foods: Limit sugar intake and processed meals because they can cause insulin resistance and inflammation, both of which can suppress testosterone levels. Consuming less sugar and processed food can support the maintenance of an optimal hormonal balance.
  • Include Healthy Fats: Incorporate sources of healthy fats such as avocados, nuts, seeds, and olive oil into your diet. These fats support hormone production.
  • Zinc-rich foods: Zinc is a key mineral for testosterone production. Include zinc-rich foods such as oysters, red meat, poultry, and beans in your diet.
  • Vitamin D: Adequate vitamin D levels are essential for testosterone production. Get regular exposure to sunlight and consider vitamin D supplements if necessary.
  • Limit Alcohol and Avoid Excessive Caffeine: Excessive alcohol consumption and caffeine intake can negatively affect hormone balance. Moderate alcohol consumption and limiting caffeine intake can help maintain good testosterone levels.

Regular Exercise

  • Strength Training: Resistance or strength training exercises can boost testosterone levels. Focus on compound movements like squats, deadlifts, and bench presses for maximum effect.
  • High-Intensity Interval Training (HIIT): HIIT workouts have been shown to increase testosterone levels. Short bursts of high-intensity exercise followed by brief rest periods can be effective.
  • Aerobic Exercise: Regular aerobic exercise, such as jogging or swimming, can help maintain overall health, which indirectly supports hormonal balance.

Adequate Sleep

  • Prioritize good quality sleep by aiming for 7 to 9 hours per night. Sleep is critical for hormonal regulation, and sleep deprivation can lead to reduced testosterone levels.

Stress Management

  • Chronic stress can lead to elevated cortisol levels, which can suppress testosterone production. Practice stress-reduction techniques like meditation, yoga, deep breathing, or mindfulness to manage stress effectively.

Weight Management

  • Maintaining a healthy weight and reducing excess body fat can help optimize testosterone levels. Obesity is often associated with lower testosterone levels.

Herbal Supplements

  • Some herbal supplements, such as ashwagandha, fenugreek, and Tribulus terrestris, are believed to have testosterone-boosting properties. Consult with a healthcare provider before taking any supplements.

Medical Check-Up

  • Consult a medical practitioner for a comprehensive evaluation if you suspect low testosterone levels or show symptoms like weariness, decreased libido, or mood swings. If required, a practitioner can offer specific suggestions or medical care.

Depending on the individual, these natural remedies may or may not be beneficial. Individual characteristics such as age and underlying medical issues might have an impact on the outcome, and lifestyle adjustments may take some time to show obvious improvements. It is advisable to get advice and monitoring from a healthcare professional, especially if you are thinking about making major dietary or activity changes or if you think you may have a hormone imbalance.

LifeDNA’s Testosterone Report

A comprehensive and understandable testosterone assessment is included in LifeDNA’s Fitness assessment. LifeDNA uses the most cutting-edge technology and the most recent scientific research to give you thorough and simple-to-understand Fitness Reports that cover everything from giving you complete reports about your physical attributes to telling you which foods and nutrients are best for you and helping you increase your testosterone levels. Try LifeDNA today.

Summary

  • Males and females both have testosterone, albeit in varying amounts. This essential hormone is critical for male sexual and reproductive development. 
  • Female ovaries produce low levels of testosterone, which aids in preserving a balanced hormonal environment. Testosterone aids females in maintaining their bone density, muscle mass, and sexual desire. However, the levels are far lower than they are for men. 
  • One aspect is genetics, but non-genetic factors can also have an impact on testosterone levels and their effects. A person’s lifestyle decisions, environmental factors, and general health have a big impact on their hormonal profile.
  • It can be harmful to have too little or too much testosterone. Low testosterone levels (associated with hypogonadism) can cause fatigue, mood fluctuations, physical weakness, and diminished libido. 
  • An excess of testosterone can cause a number of health issues, including acne, aggression, and an increased risk of cardiovascular illnesses.
  • A balanced testosterone level is essential for preserving the best possible health and well-being.

References

Customer Reviews

Christopher Devlin
Christopher Devlin
LifeDNA Customer
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I am so impressed with this service. I have even discussed these recommendations with my health care providers and they are all impressed too! I can’t compare it with other services as I have only tried this but I recommend. Also I think I pulled my genetics in from ancestry too which was super convenient.
Lei'a
Lei'a
LifeDNA Customer
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Great source of information I was looking for a platform to make use of my existing raw data from Ancestry. I’m glad I found LifeDNA. I originally took a DNA test to learn about my roots and it’s great to know that my DNA could also play a big role in my health, diet, and even my skin. Overall, all the reports are incredible.
Shiraz Dole
Shiraz Dole
LifeDNA Customer
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It is crazy how I felt that I had a strong understanding of my bodies needs, but after having my DNA analyzed by the LifeDNA team, I realized that there was so much I still did not know.
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Doc Sheila Lim
LifeDNA Customer
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I got some pretty useful insight that helped me with my diet.
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By concentrating on the components of a situation that you can control and confronting negative thought patterns, you can cultivate a positive view. By enhancing drive and lowering feelings of hopelessness, optimism might enhance resilience. Accept change and uncertainty as chances for development. Flexibility makes it easier to adjust to changing conditions and lowers resistance to change, both of which can increase resilience.

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

The right vitamins for bone health based on DNA

Your Bone and Joint Health: How Your DNA Can Affect Your Vitamin D Levels

bones and joints

If you love moderate sunbathing, you are probably already more than familiar with Vitamin D and its benefits. A fat-soluble vitamin, Vitamin D is known to be both a nutrient people need from their daily diet and a hormone that the human body naturally makes. This vitamin is known to help the body absorb other vitamins and minerals needed for bone health such as calcium and phosphorus. 


Some studies also suggest that Vitamin D can help reduce the growth of cancer cells, reduce inflammation, and lessen the risks of many infectious diseases. Some individuals are born able to absorb and retain Vitamin D better than others. Genetic variations may help your body to become more attuned to the vitamins and minerals you need. If you want to know more about how your genetics affect your vitamin, mineral, and other nutrient absorption that can affect your bone health, take a DNA test now.

The Connection Between Vitamin D and Bone Health

Calcium is a critical component in the building and maintenance of bones. Vitamin D is an important co-factor in the absorption and storage of calcium, thus, this vitamin helps maintain good bone health. People with low levels of Vitamin D often also have joint pain. This nutrient can be gained through various ways including exposure to (moderate sunlight, food and drinks, and bone and joint health supplements. 

 

Your absorption and retention of Vitamin D can also be affected by many factors including age, body mass index, sun exposure, diet, and lifestyle. Dairy products, oily fish, and low-fat fortified milk are some foods that can help with Vitamin D intake. Your genetic variation can also be a factor in determining whether your Vitamin D levels are at risk of being insufficient or abundant.

Suggested Daily Intake

The Recommended Dietary Allowance (RDA) for Vitamin D, excluding sun exposure, is 600 IU (15 mcg) daily for adult men and women above 19 years of age and 800 IU (20 mcg) daily for adults more than 70 years old. 


Learn more about your Vitamin D levels and other nutrient needs with LifeDNA’s genetic testing for potential vitamin and mineral insufficiencies Every plan comes with full and comprehensive wellness reports using the best and latest scientific research

Genetic Traits for Bone Health

Bones and joints

 

With today’s technology, we have a better understanding of the human body. There are now many supplements and tips on how to improve bone health after 50 to maintain optimal health and well-being despite the challenges of getting older. Other genetic factors might also affect your bone health and the nutrients needed to maintain it.

 

Vitamin D Levels

Studies suggest that serious Vitamin D deficiency can be hereditary. If you take a DNA test for vitamin deficiency and your results say that your genetic variation increases your risk of developing low levels of this vitamin, altering your diet and taking a supplement for bone health after talking to your primary care physician might help.

Calcium Levels

One of the most essential nutrients for optimal skeletal health, calcium helps build strong bones during childhood and puberty. About 99% of the body’s calcium is stored in your bones and you can get more calcium and replenish the deposits via food intake  As you age, calcium deposits in bones lessen. Less calcium means an increased risk of brittle bones and developing bone diseases like osteoporosis. A good daily intake of Vitamin D will help the body to absorb calcium. Taking a LifeDNA DNA test for Calcium Levels may help you to determine risks for Bone Health in addition to the test for potential Vitamin D levels. 

 

Phosphorus Levels

 

Phosphorus isn’t as famous as calcium, but it’s just as important for your bones and teeth. Around 85% of your body’s phosphorus is in your bones and teeth! This crucial nutrient can literally make or break your bones. And while calcium supplements might be recommended in some cases, without sufficient phosphorus, calcium can’t work effectively to maintain or strengthen your bones.

DNA Test for Potential Vitamin D Insufficiency 

Vitamin D is an essential nutrient that aids in many bodily functions, mainly in helping other nutrients’ absorption and retention. Some people are genetically predisposed to Vitamin D insufficiency while others are more likely to have stable and optimal levels. 

If you think you are at risk of developing a Vitamin D deficiency, genetic testing for a potential insufficiency with LifeDNA’s wellness reports can help you get started on your health and wellness journey. Try LifeDNA today to optimize your lifestyle and nutrition to ensure your bone and joint health.

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.